98 research outputs found

    DNA: New materials for substrate selective catalysis

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    <p>We discovered that random DNA fragments (RDF) could selectively catalyze the oxidation of peroxidase substrates under the H<sub>2</sub>O<sub>2</sub>-TMB system. The activity is closely related with the length of DNA chain. Taking advantage of simplicity and efficiency, the RDF would have potential applications in biotechnology and clinical diagnosis as enzymatic mimetics.</p

    Molecular Dynamics Simulation of Methane Hydrate Formation on Pipeline Surface in the Presence of Corrosion Inhibitors

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    Large amounts of inhibitors are consumed annually to tackle the two critical flow assurance problems of pipelines in the oil–gas industry, namely, corrosion and gas hydrate blockages. Such strategies can be optimized when the implications of corrosion inhibitor on gas hydrate formation are clarified as well as the underlying mechanisms. Therefore, molecular dynamics simulations were performed in this study to elucidate the effects of a conventional imidazoline corrosion inhibitor [1-(2-aminoethyl)-11-alkyl-imidazoline, AAI] on the formation of methane hydrate. A significant hydrate kinetics inhibition effect was observed according to the F4φ analysis at different locations. The ability of AAI to inhibit the hydrate formation was mainly attributed to its constituent of the hydrophobic group, which either displaced the methane molecules and destroyed the stability of water cages (AAI concentration at 4.9%), or separated the methane from the water molecules to markedly reduce their interactions (AAI concentration at 10.3%). In contrast, the contributions by the hydrophilic group of AAI were secondary with respect to the limited contact with water to disrupt the hydrogen bonds of the water cages. The thermodynamic analysis revealed that the methane hydrate particles were hardly deposited on the AAI-covered pipeline surface due to the strong repulsion effect of the hydrophobic groups on the water cages. Such molecular insights provide theoretical guidance for evaluating the functional groups of corrosion inhibitors that may affect the formation of gas hydrates and, subsequently, modifying these functional groups to achieve a dual inhibition influence on both pipeline corrosion and gas hydrate formation

    A Facile One-Pot Method to Synthesize a Polypyrrole/Hemin Nanocomposite and Its Application in Biosensor, Dye Removal, and Photothermal Therapy

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    In this work, we introduced a facile method for the construction of a polypyrrole/hemin (PPy/hemin) nanocomposite via one-pot chemical oxidative polymerization. In this process, a hemin molecule serving as a dopant was entrapped in the PPy nanocomposite during chemical oxidative polymerization. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and UV–visible spectroscopy results demonstrated that the PPy/hemin nanocomposite was successfully synthesized. The as-prepared nanocomposite exhibited intrinsic peroxidase-like catalytic activities, strong adsorption properties, and an excellent near-infrared (NIR) light-induced thermal effect. We utilized the nanomaterials to catalyze the oxidation of a peroxidase substrate 3,3,5,5-tetramethylbenzidine by H<sub>2</sub>O<sub>2</sub> to the oxidized colored product which provided a colorimetric detection of glucose. As low as 50 μM glucose could be detected with a linear range from 0.05 to 8 mM. Moreover, the obtained nanocomposite also showed excellent removal efficiency for methyl orange and rhodamine B and a photothermal effect, which implied a promising application as the pollutant adsorbent and photothermal agent. The unique nature of the PPy/hemin nanocomposite makes it very promising for the fabrication of inexpensive, high-performance bioelectronic devices in the future

    Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized trials.

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    <p>Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized trials.</p

    Relative risk of Grade III/IV adverse events in patients treates with TACE plus sorafenib versus TACE.

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    <p>Relative risk of Grade III/IV adverse events in patients treates with TACE plus sorafenib versus TACE.</p

    Objective response rate (ORR) for the combination of TACE plus sorafenib with TACE.

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    <p>Objective response rate (ORR) for the combination of TACE plus sorafenib with TACE.</p

    Overall survival (OS), time to progression (TTP), and progression.

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    <p>Overall survival (OS), time to progression (TTP), and progression.</p

    Eligibility of studies for inclusion in the meta-analysis.

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    <p>Eligibility of studies for inclusion in the meta-analysis.</p
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