17 research outputs found

    Designing Poly(arylene ether sulfone)s with Platinum(II) Acetylide to Regulate Photophysical Properties toward Solid-State Nonlinear Limiters

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    The exploration of solid-state optical power limiting (OPL) materials based on nonlinear absorption (NLA) with heat resistance is essential and leading-edge. We present two types of poly(arylene ether sulfone)s (PAESs) derived from platinum acetylide, featuring varying conjugation lengths and platinum contents. The platinum-incorporated PAESs exhibit outstanding thermal properties (Tg > 180 °C, Td5% ≥ 400 °C) with easy processing into solid films from solvents. Photophysics, ultrafast transient absorption, Z-scan characterizations, and theoretical calculations reveal an abnormal intersystem crossing and the principle of triplet nonlinear limiting (S0 → S1 → Tx → T1 → Tn). The extended τP caused by the longer conjugated ligand is more critical for NLA compared with the lower ΦP caused by higher Pt contents. PAESs with a longer conjugated ligand exhibit superior intrinsic NLA under limited platinum content, while those with shorter conjugated ligands strike a balance between transparency and NLA. The optical limiting threshold (Fth) of the solid-state film is as low as 1.86 J/cm2. This study involves the preparation of solid-state OPL films using platinum-modified PAESs, revealing an intrinsic link between structure and optical properties

    Additional file 8: of A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

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    LINC00470 promoted GBM cell proliferation. CCK8 assay was performed to determine the viability of primary GBM cells. Primary GBM cells were transfected with si-NC and si-LINC00470, pcDNA3.1, and pcDNA3.1-LINC00470, respectively.*p < 0.05, **p < 0.01. (DOCX 935 kb

    Additional file 5: of A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

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    The associate between LINC00470, FUS, and AKT in U87 cells. A: the interaction of LINC00470 and FUS was detected through RIP assays in U87 cells. Data are presented as the mean ± S.E.M. of three independent experiments. **p < 0.01. B: RNA pulldown showed binding between LINC00470 and FUS. Data are presented as the mean ± S.E.M. of three independent experiments. C: RIP assays showed that there was no interaction between LINC00470 and AKT in U87 cells. Data are presented as the mean ± S.E.M. of three independent experiments. (DOCX 264 kb

    Additional file 1: of A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

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    Bioinformatics analyses of evolutional conservation and protein-coding potential of LINC00470. A: the analysis of protein coding potential of LINC00470 using tools provided by the Peking University Center for Bioinformatics (cpc.cbi.pku.edu.cn/programs/run_cpc.jsp) shows LINC00470 lack of protein-coding capability. B: plasmids as schematically shown at left were transfected to HEK293 cells (right). Immunoblotting using antibody specific to ERK and fluorescent imaging showed that LINC0040-EGFP plasmid did not express GFP. (DOCX 755 kb

    Additional file 2: of A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

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    The relationship between LINC00470, AKT, and p-AKT. A: RT-qPCR and Western blotting measured the expression of LINC00470 and AKT in GBM cell lines and primary GBM cells. Data presented as mean ± S.E.M. of three independent experiments. B: Western blotting measured the expression of AKT and p-AKT in GBM cell lines and primary GBM cells. Data showed positive correlation between the expression of LINC00470 and p-AKT in GBM. (DOCX 302 kb

    Additional file 6: of A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

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    LINC00470, FUS, and AKT can form a ternary complex in U251 cells. The expression levels of LINC00470, AKT, and FUS were measured by RT-qPCR and Western blotting, respectively. Data presented as mean ± S.E.M. of three independent experiments. (DOCX 1262 kb

    Haplotypes of <i>AKT1</i> polymorphisms and the risk of nasopharyngeal carcinoma.

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    <p>(<i>a</i>) Genomic structure of the <i>AKT1</i> locus and the polymorphic sites used. Exons (boxes) and introns are not drawn to scale; open boxes represent noncoding sequences, and filled boxes represent coding sequences. The physical distance between SNPs is shown in nucleotides. (<i>b</i>) Linkage disequilibrium (LD) map of SNPs based on <i>D</i> ´. (<i>c</i>) LD map of SNPs based on <i>r</i><sup>2</sup>. (<i>d</i>) Global <i>P</i> values from single-locus and multi-locus (two to five) based association analysis. (<i>e</i>) Haplotypes showing significant genetic associations with the risk of nasopharyngeal carcinoma. The two-SNP core haplotype is highlighted in gray.</p
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