Synthesis of Decahydropyrrolo[2,1,5-<i>cd</i>]indolizine through Consecutive [2 + 3] Cycloadditions and 6-Exo-Trig Cyclization

Azomethine ylide formed from glycine methyl ester and cinnamaldehyde adds to N-phenylmaleimide to form pyrrolidine derivative, further treatment of which with cinnamaldehyde and N-phenylmaleimide affords the second [2 + 3] cycloaddition adduct, a pyrrolizine derivative with two styrenyl groups at the 3,5-positions. Addition of ICl to the pyrrolizine derivative results in the 6-exo-trig cyclization of the styrenyl groups to form a cycl[3.2.2]azine derivative. The reactions are highly stereoselective affording 11 chiral carbons in three steps. The structure of the cycl[3.2.2]azine derivative was determined by single-crystal X-ray analysis

An Open Neodymium−Organic Framework with the NbO Structure Type Based on Binuclear SBU Involved In Situ Generated Formate

The solvothermal reaction of Nd(NO3)3·6H2O and 5-amino-2,4,6-triiodoisophthalic acid (H2atiip) in DMF/ethonal/H2O (5:2:1) in the presence of pyridine gave rise to a new open neodymium−organic framework having the NbO structure type, [Nd(HCOO)(atiip)(DMF)2]·DMF·H2O (1). Complex 1 can keep its diffraction pattern even after being heated to 200 °C

An Open Neodymium−Organic Framework with the NbO Structure Type Based on Binuclear SBU Involved In Situ Generated Formate

The solvothermal reaction of Nd(NO3)3·6H2O and 5-amino-2,4,6-triiodoisophthalic acid (H2atiip) in DMF/ethonal/H2O (5:2:1) in the presence of pyridine gave rise to a new open neodymium−organic framework having the NbO structure type, [Nd(HCOO)(atiip)(DMF)2]·DMF·H2O (1). Complex 1 can keep its diffraction pattern even after being heated to 200 °C

An Open Neodymium−Organic Framework with the NbO Structure Type Based on Binuclear SBU Involved In Situ Generated Formate

The solvothermal reaction of Nd(NO3)3·6H2O and 5-amino-2,4,6-triiodoisophthalic acid (H2atiip) in DMF/ethonal/H2O (5:2:1) in the presence of pyridine gave rise to a new open neodymium−organic framework having the NbO structure type, [Nd(HCOO)(atiip)(DMF)2]·DMF·H2O (1). Complex 1 can keep its diffraction pattern even after being heated to 200 °C

An Open Neodymium−Organic Framework with the NbO Structure Type Based on Binuclear SBU Involved In Situ Generated Formate

The solvothermal reaction of Nd(NO3)3·6H2O and 5-amino-2,4,6-triiodoisophthalic acid (H2atiip) in DMF/ethonal/H2O (5:2:1) in the presence of pyridine gave rise to a new open neodymium−organic framework having the NbO structure type, [Nd(HCOO)(atiip)(DMF)2]·DMF·H2O (1). Complex 1 can keep its diffraction pattern even after being heated to 200 °C

An Open Neodymium−Organic Framework with the NbO Structure Type Based on Binuclear SBU Involved In Situ Generated Formate

The solvothermal reaction of Nd(NO3)3·6H2O and 5-amino-2,4,6-triiodoisophthalic acid (H2atiip) in DMF/ethonal/H2O (5:2:1) in the presence of pyridine gave rise to a new open neodymium−organic framework having the NbO structure type, [Nd(HCOO)(atiip)(DMF)2]·DMF·H2O (1). Complex 1 can keep its diffraction pattern even after being heated to 200 °C

Synthesis of Decahydropyrrolo[2,1,5-<i>cd</i>]indolizine through Consecutive [2 + 3] Cycloadditions and 6-Exo-Trig Cyclization

Azomethine ylide formed from glycine methyl ester and cinnamaldehyde adds to N-phenylmaleimide to form pyrrolidine derivative, further treatment of which with cinnamaldehyde and N-phenylmaleimide affords the second [2 + 3] cycloaddition adduct, a pyrrolizine derivative with two styrenyl groups at the 3,5-positions. Addition of ICl to the pyrrolizine derivative results in the 6-exo-trig cyclization of the styrenyl groups to form a cycl[3.2.2]azine derivative. The reactions are highly stereoselective affording 11 chiral carbons in three steps. The structure of the cycl[3.2.2]azine derivative was determined by single-crystal X-ray analysis

Two Solvent-Dependent Zinc(II) Supramolecular Isomers: Rare <b>kgd</b> and Lonsdaleite Network Topologies Based on a Tripodal Flexible Ligand

Two Zn(II) supramolecular isomeric metal–organic frameworks (MOFs) based on well-designed tripodal tris(2-carboxyethyl)isocyanuric acid (H3tci), formulated as [(Me2NH2)Zn(tci)·0.5DMF]n (1) and [(Me2NH2)Zn(tci)·2DMF]n (2) (Me2NH2 = protonated dimethylamine, DMF = N,N-dimethylformamide) have been solvothermally synthesized and characterized. Compounds 1 and 2 are supramolecular isomers controlled by solvent systems and exhibit a structural progression from a rare two-dimensional kgd sheet to a three-dimensional framework with unusual Lonsdaleite (lon) topology. The structural dissimilarity between them was dependent on the coordination environments of the Zn(II) ion and linking modes of the tci ligand influenced by solvent systems. The photoluminescence behaviors of 1 and 2 are also discussed

Two Solvent-Dependent Zinc(II) Supramolecular Isomers: Rare <b>kgd</b> and Lonsdaleite Network Topologies Based on a Tripodal Flexible Ligand

Two Zn(II) supramolecular isomeric metal–organic frameworks (MOFs) based on well-designed tripodal tris(2-carboxyethyl)isocyanuric acid (H3tci), formulated as [(Me2NH2)Zn(tci)·0.5DMF]n (1) and [(Me2NH2)Zn(tci)·2DMF]n (2) (Me2NH2 = protonated dimethylamine, DMF = N,N-dimethylformamide) have been solvothermally synthesized and characterized. Compounds 1 and 2 are supramolecular isomers controlled by solvent systems and exhibit a structural progression from a rare two-dimensional kgd sheet to a three-dimensional framework with unusual Lonsdaleite (lon) topology. The structural dissimilarity between them was dependent on the coordination environments of the Zn(II) ion and linking modes of the tci ligand influenced by solvent systems. The photoluminescence behaviors of 1 and 2 are also discussed

Synthesis and anticancer evaluation of new disulfides incorporating naphthalimide moiety

A series of new disulfides incorporating naphthalimide moiety were designed, synthesized and biologically evaluated against three human cancer cell lines (MCF-7, SMMC-7721 and Hela). Most of target compounds exhibited some degrees of anticancer activities, and some compounds displayed better effects than reference drugs PX-12 and 5-FU against the tested three cancer cells. Especially, compound 7d showed the most potent antiproliferative activity against MCF-7 cell lines with IC50 value of 3.19 μM. Compound 8a displayed prominent anticancer property against SMMC-7721 cell lines with IC50 value of 1.84 μM. Compound 6c possessed the most effective proliferation inhibitory activity against Hela cell lines with IC50 value of 2.14 μM. In addition, cytotoxicity evaluation indicated that most of the compounds had weak cytotoxicity to L929 cell lines.</p