9 research outputs found

    A Technological and Typological Analysis of Lithic Material from Skovmosen I, Denmark

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     During road construction work, material attributed to the Final Palaeolithic was discovered at Skovmosen I, near Kongens Lyngby on Zealand, eastern Denmark. Although it is regularly mentioned in reviews of the southern Scandinavian Final Palaeolithic, the Skovmosen I assemblage has hitherto remained poorly described. We here review the site’s discovery history and its context. Aided by a three-dimensional digital recording protocol, this article details the assemblage composition and its technology. The assemblage is comprised of tanged points, scrapers and burins, alongside blades and cores as primary reduction products. Although evidently disturbed by the road construction that led to the site’s discovery, the material likely reflects the remains of a small Final Palaeolithic locale, where diverse activities were carried out

    Tidsrummet for Hamborgkulturens bosættelse ved Jelssøerne kommenteret gennem forsøg på flintsammensætning

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    As the Weichselian glaciation came toan end, the Fennoscandian ice sheet retreatedand left behind young morainelandscapes, today referred to as southernScandinavia. During this so-called LastGlacial-Interglacial Transition humansbegan to colonise the recently de-glaciatedarea with the earliest colonisationattempt taking place during the Bølling/Meiendorf chronozone (G I-1e). Thesepioneer settlers of the region broughtwith them a lithic repertoire of theHamburgian Havelte tradition and arein Denmark known from sites separatedinto two somewhat delineated occupationareas, one of which is in southernJutland at the Jels Lakes. The sites withinthis settlement pocket are similar inseveralaspects, and interpretations ofthese sites making out one concurrentoccupation have previously been proposed,yet rarely followed up upon. Inthis paper the question of contemporaneitybetween the two sites is revisited.With relevance to the rhythms of settlementor, indeed, of contemporaneity,within the Hamburgian micro-regionat Jels, first attempts at refitting lithicmaterial from these sites have been conducted.Impressions are here presentedand future perspectives assessed

    Farming during turbulent times: agriculture, food crops, and manuring practices in Bronze Age to Viking Age Denmark

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    Archaeobotanical and stable isotope analysis on plant remains from 39 sites spanning the Bronze, Iron, and Viking Ages in Denmark has been undertaken in order to investigate the development and resilience of agricultural practices, particularly through the 1250-year-long Iron Age (500 BC – AD 750). During this time, an increase in the spectrum of food resources can be seen in the archaeobotanical material. At the same time, soil enrichment of fields of barley, which increased markedly during the Bronze−Iron Age transition, remains consistent until the Viking Age. A more broad-spectrum diet appears to tie in with agricultural extensification comprising increased scales of land use and fallowing alongside possibly less intense tillage of fields. These practices appear to have made agriculture resilient to climatic fluctuations during our study period, with the possible exception of a shift following volcanic eruptions in AD 536/540

    Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties

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    Abstract Exosomes are small secreted vesicles that can transfer their content to recipient cells. In cancer, exosome secretion has been implicated in tumor growth and metastatic spread. In this study, we explored the possibility that exosomal pathways might discard tumor-suppressor miRNA that restricts metastatic progression. Secreted miRNA characterized from isogenic bladder carcinoma cell lines with differing metastatic potential were uncoupled from binding to target transcripts or the AGO2–miRISC complex. In metastatic cells, we observed a relative increase in secretion of miRNA with tumor-suppressor functions, including miR23b, miR224, and miR921. Ectopic expression of miR23b inhibited invasion, anoikis, angiogenesis, and pulmonary metastasis. Silencing of the exocytotic RAB family members RAB27A or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion. Clinically, elevated levels of RAB27B expression were linked to poor prognosis in two independent cohorts of patients with bladder cancer. Moreover, highly exocytosed miRNA from metastatic cells, such as miR23b, were reduced in lymph node metastases compared with patient-matched primary tumors and were correlated with increments in miRNA-targeted RNA. Taken together, our results suggested that exosome-mediated secretion of tumor-suppressor miRNA is selected during tumor progression as a mechanism to coordinate activation of a metastatic cascade. Cancer Res; 74(20); 5758–71. ©2014 AACR.</jats:p

    European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

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    European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

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