Aproximación al humor de Tono

Antonio de Lara, Tono, es el autor menos estudiado de la llamada "la otra generación del 27". En este artículo se estudia su influencia en el marco de su época y cuál era la opinión de sus compañeros generacionales. Sin embargo, la parte más relevante es la aproximación a su teoría del humor. Se describe la estrategia cómica escogida para sortear la censura. Finalmente, se reconoce su valor como autor cómico en la historia reciente del teatro español.Tono is one of the most unknown comic dramatist of the generation call «la otra generación del 27». We will study his influence in the period that he lived and also the opinion of his generation friends. And the most important part of this study is our approximation to his humour. We will describe the comic way he prefered in order to escape from the troubles of censorship. Finally, we will try to appreciate his role as a comic author in the recent history of the Spanish drama

Translation and validation of Hyperhidrosis Disease Severity Scale

Introduction: The evaluation of patients with hyperhidrosis (HH) can be accomplished, among other ways, through questionnaires and scales. The Hyperhidrosis Disease Severity Scale (HDSS) has been used as a simple and quick tool to perform this evaluation. Although HDSS has been well established in several languages, it has not been translated into Portuguese, restricting its specific use for Brazilian patients. The aim of this study was to translate HDSS into Portuguese and validate it in a sample of Brazilian subjects. Method: 290 Brazilian patients (69% women, with a mean age of 28.7±9.6 years and BMI 22.4±3.9 kg/m2) diagnosed with HH were evaluated using HDSS, Quality of Life Questionnaire (QLQ) and Sweating Evolution Questionnaire (SEQ) before and after a five-week oxybutynin treatment. Regarding validation, an association between HDSS results and two other questionnaires was performed. To analyze HDSS sensitivity, evaluation of effects pre- and post-treatment with oxybutynin was conducted. Furthermore, HDSS reproducibility was analyzed in a subsample in which the scale was applied again after 7 days of the first follow-up appointment. Results: There was statistical correlation between HDSS and QLQ and between HDSS and SEQ before treatment and after 5 weeks. Additionally, HDSS was reproducible and sensitive to clinical changes after the treatment period. Conclusion: The Portuguese version of HDSS has been validated and shown to be reproducible in a Brazilian sample. Therefore it can be used as a tool to improve medical assistance in patients with HH

Design of a collaborative virtual environment for training security agents in big events

This paper describes a design of a collaborative virtual environment (CVE) for training security agents in big events. The CVE was modelled with Autodesk 3ds Max, while Unity 3D was used to create the terrain and implement the features that make up a virtual environment. The Brazilian soccer stadium known as Maracana˜ and its surroundings were chosen as the real counterparts of the CVE. The usability of the CVE was evaluated through simulations involving security agents dealing with threats related to suspects carrying radioactive material in big events. In order to perform these simulations, we use the same procedures used during 2014 FIFA World Cup and planned to be used in Rio 2016 Olympic Games. The main objective of this work is to verify the feasibility of designing a CVE and its usability for training security agents involved in big events issues. Results indicated that the proposed CVE has been successful concerning both, design and usability, besides of helping to improve the ability of each member of the security team on performing his duty

Planeamento sustentável em saúde: percepções sobre termos, conceitos e características processuais e metodológicas

Introdução: Nas últimas décadas, o reconhecimento do papel central da saúde para o alcance do desenvolvimento sustentável tem provocado desafios específicos ao processo de planeamento do desenvolvimento, em geral, e do planeamento em saúde, em particular. Integrado num projeto de investigação mais vasto, com a finalidade de contribuir para o desenvolvimento de um modelo de planeamento em saúde no quadro dos Objetivos de Desenvolvimento Sustentável (ODS), este estudo, de carácter exploratório, tem por objetivo contribuir para a compreensão de conceitos e características processuais e metodológicas do planeamento sustentável em saúde, com base nas principais mensagens recolhidas num painel de discussão realizado durante o 5º Congresso Nacional de Medicina Tropical em abril de 2019. Material e Métodos: As apresentações dos oradores convidados para o painel e as transcrições das intervenções no debate foram submetidas a análise de conteúdo. Adicionalmente, foi conduzida uma análise documental de fontes documentais resultantes de uma revisão da literatura de tipo narrativa, que permitiu uma recolha de elementos para complementar e enquadrar os achados da análise de conteúdo e a discussão da temática. Resultados e discussão: Emergiram 4 temas principais: i) perceções do planeamento sustentável, II) planeamento sustentável e participação dos cidadãos, III) planeamento sustentável e articulação intersectorial, e IV) planeamento sustentável e condições de implementação. As perceções do planeamento sustentável foram das mais diversas, por exemplo, o planeamento que garante a implementação ou a continuidade do ciclo de planeamento, e só uma minoria dos participantes enquadrou o planeamento sustentável como sendo aquele que contribui para a consecução dos ODS. As abordagens participativas do planeamento em saúde, que integram a participação dos cidadãos e a articulação intersectorial, com particular enfoque na redução das iniquidades em saúde e no alcance da cobertura universal, foram consideradas entre as mais efetivas para o alcance de objetivos de saúde e de bem-estar alinhados com os princípios do desenvolvimento sustentável. Conclusão: A mobilização social e das comunidades no processo de planeamento em saúde parece ser facilitador da seleção e implementação de estratégias de saúde no contexto do desenvolvimento sustentável.N/

Monitoramento das helmintoses gastrintestinais em rebanho leiteiro criado em sistema de produção orgânica na Fazendinha Agroecológica.

O objetivo deste trabalho foi utilizar técnicas parasitológicas para monitorar o grau de parasitismo como subsídio para a criação de programas de controle das infecções por nematóides gastrintestinais em vacas leiteiras criadas em sistema orgânico na Fazendinha Agroecológica, convênio Embrapa/Universidade Federal Rural do Rio de Janeiro (UFRuralRJ)/Pesagro-Rio

Best practices: in the 21st century, taxonomic decisions in herpetology are acceptable only when supported by a body of evidence and published via peer-review

This paper was written by nine authors from five continents, and supported by a further 80 academics and many major herpetological societies including the World Congress of Herpetology, in reaction to burgeoning number of species descriptions being published in herpetology by a small number of individuals through their own self-published "journals" which lack any peer-review

Spatial variability of the texture in a Red-Yellow Ultisol under pasture and nature vegetation crop

O conhecimento da variabilidade espacial dos atributos de um solo sob diferentes coberturas auxilia o estudo das alterações ocorridas em razão do manejo. O objetivo deste trabalho foi determinar, com uso da estatística clássica e geoestatística, a variabilidade espacial das frações texturais de um solo cultivado com pastagem e vegetação nativa. Amostras de solo foram coletadas na profundidade de 0-0,20m, nos pontos de cruzamento de uma malha, com intervalos regulares de 10m, totalizando 64 pontos em cada área. Na área de pastagem, as frações areia grossa e total apresentaram valores médios maiores em relação à vegetação nativa e correlações negativas com as altitudes dos pontos amostrais nas duas áreas. Todas as frações texturais apresentaram dependência espacial de moderada a alta nas duas áreas e com o patamar definido, com exceção da areia fina e do silte na pastagem. Grande parte dessa variabilidade ocorre em função da erosão hídrica.The study of the spatial variability of soil attributes under different crop helps the study of changes due the management. This research was carried out to determine spatial variability the particle-size distribution, using of the classic statistic and geostatistics, of a soil cultivated with pasture and native vegetation. Soil samples were collected in the layer 0-0.20m, at the crossing points of a regular grid with 10m-intervals, summing up 64 samples points in each area. In the pasture area the fractions of coarse and total sand presented larger mean values in relation to the native vegetation, and negative correlation with the altitude of the points samples in the two areas. All of the fractions presented moderate to high spatial dependence in the two areas and with the defined still, with exception of the fine sand and the silt in the pasture. Much of this variability occurs as a function of water erosion

Novel pathogenic mutations and skin biopsy analysis in Knobloch syndrome

Purpose: To facilitate future diagnosis of Knobloch syndrome (KS) and better understand its etiology, we sought to identify not yet described COL18A1 mutations in KS patients. In addition, we tested whether mutations in this gene lead to absence of the COL18A1 gene product and attempted to better characterize the functional effect of a previously reported missense mutation. Methods: Direct sequencing of COL18A1 exons was performed in KS patients from four unrelated pedigrees. We used immunofluorescent histochemistry in skin biopsies to evaluate the presence of type XVIII collagen in four KS patients carrying two already described mutations: c. 3277C>T, a nonsense mutation, and c. 3601G>A, a missense mutation. Furthermore, we determined the binding properties of the mutated endostatin domain p.A1381T (c.3601G>A) to extracellular matrix proteins using ELISA and surface plasmon resonance assays. Results: We identified four novel mutations in COL18A1, including a large deletion involving exon 41. Skin biopsies from KS patients revealed lack of type XVIII collagen in epithelial basement membranes and blood vessels. We also found a reduced affinity of p.A1381T endostatin to some extracellular matrix components. Conclusions: COL18A1 mutations involved in Knobloch syndrome have a distribution bias toward the coding exons of the C-terminal end. Large deletions must also be considered when point mutations are not identified in patients with characteristic KS phenotype. We report, for the first time, lack of type XVIII collagen in KS patients by immunofluorescent histochemistry in skin biopsy samples. As a final point, we suggest the employment of this technique as a preliminary and complementary test for diagnosis of KS in cases when mutation screening either does not detect mutations or reveals mutations of uncertain effect, such as the p.A1381T change.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) - CEPIDConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq

Numerical relations and skill level constrain co-adaptive behaviors of agents in sports teams

Similar to other complex systems in nature (e.g., a hunting pack, flocks of birds), sports teams have been modeled as social neurobiological systems in which interpersonal coordination tendencies of agents underpin team swarming behaviors. Swarming is seen as the result of agent co-adaptation to ecological constraints of performance environments by collectively perceiving specific possibilities for action (affordances for self and shared affordances). A major principle of invasion team sports assumed to promote effective performance is to outnumber the opposition (creation of numerical overloads) during different performance phases (attack and defense) in spatial regions adjacent to the ball. Such performance principles are assimilated by system agents through manipulation of numerical relations between teams during training in order to create artificially asymmetrical performance contexts to simulate overloaded and underloaded situations. Here we evaluated effects of different numerical relations differentiated by agent skill level, examining emergent inter-individual, intra- and inter-team coordination. Groups of association football players (national - NLP and regional-level - RLP) participated in small-sided and conditioned games in which numerical relations between system agents were manipulated (5v5, 5v4 and 5v3). Typical grouping tendencies in sports teams (major ranges, stretch indices, distances of team centers to goals and distances between the teams' opposing line-forces in specific team sectors) were recorded by plotting positional coordinates of individual agents through continuous GPS tracking. Results showed that creation of numerical asymmetries during training constrained agents' individual dominant regions, the underloaded teams' compactness and each team's relative position on-field, as well as distances between specific team sectors. We also observed how skill level impacted individual and team coordination tendencies. Data revealed emergence of co-adaptive behaviors between interacting neurobiological social system agents in the context of sport performance. Such observations have broader implications for training design involving manipulations of numerical relations between interacting members of social collectives