4,665 research outputs found

    Application of the ATLAS DAQ and Monitoring System for MDT and RPC Commissioning

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    The ATLAS DAQ and monitoring software are currently commonly used to test detectors during the commissioning phase. In this paper, their usage in MDT and RPC commissioning is described, both at the surface pre-commissioning and commissioning stations and in the ATLAS pit. Two main components are heavily used for detector tests. The ROD Crate DAQ software is based on the ATLAS Readout application. Based on the plug-in mechanism, it provides a complete environment to interface any kind of detector or trigger electronics to the ATLAS DAQ system. All the possible flavours of this application are used to test and run the MDT and RPC detectors at the pre-commissioning and commissioning sites. Ad-hoc plug-ins have been developed to implement data readout via VME, both with ROD prototypes and emulating final electronics to read out data with temporary solutions, and to provide trigger distribution and busy management in a multi-crate environment. Data driven event building functionality is also used to combine data from different detector technologies. Monitoring software provides a framework for on-line analysis during detector test. Monitoring applications have been developed for noise and cosmic tests and for pulse runs. The PERSINT event display has been interfaced to the monitoring system to provide an on-line event display for cosmic runs in the ATLAS pit

    The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain

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    BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent the association of SMRT with BCL6, inhibit transcriptional repression and cause apoptosis of lymphoma cells in vitro and in vivo. In order to discover compounds, which have the potential to be developed into BCL6 inhibitors, we screened a natural product library. The ansamycin antibiotic, rifamycin SV, inhibited BCL6 transcriptional repression and NMR spectroscopy confirmed a direct interaction between rifamycin SV and BCL6. To further determine the characteristics of compounds binding to BCL6-POZ we analyzed four other members of this family and showed that rifabutin, bound most strongly. An X-ray crystal structure of the rifabutin-BCL6 complex revealed that rifabutin occupies a partly non-polar pocket making interactions with tyrosine58, asparagine21 and arginine24 of the BCL6-POZ domain. Importantly these residues are also important for the interaction of BLC6 with SMRT. This work demonstrates a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor

    Study of the a_0(980) meson via the radiative decay phi->eta pi^0 gamma with the KLOE detector

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    We have studied the phi->a_0(980) gamma process with the KLOE detector at the Frascati phi-factory DAPhNE by detecting the phi->eta pi^0 gamma decays in the final states with eta->gamma gamma and eta->pi^+ pi^- pi^0. We have measured the branching ratios for both final states: Br(phi->eta pi^0 gamma)=(7.01 +/- 0.10 +/- 0.20)x10^-5 and (7.12 +/- 0.13 +/- 0.22)x10^-5 respectively. We have also extracted the a_0(980) mass and its couplings to eta pi^0, K^+ K^-, and to the phi meson from the fit of the eta pi^0 invariant mass distributions using different phenomenological models.Comment: 17 pages, 6 figures, submitted to Physics Letters B. Corrected typos in eq.

    A global fit to determine the pseudoscalar mixing angle and the gluonium content of the eta' meson

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    We update the values of the eta-eta' mixing angle and of the eta' gluonium content by fitting our measurement R_phi = BR(phi to eta' gamma)/ BR(phi to eta gamma) together with several vector meson radiative decays to pseudoscalars (V to P gamma), pseudoscalar mesons radiative decays to vectors (P to V gamma) and the eta' to gamma gamma, pi^0 to gamma gamma widths. From the fit we extract a gluonium fraction of Z^2_G = 0.12 +- 0.04, the pseudoscalar mixing angle psi_P = (40.4 +- 0.6) degree and the phi-omega mixing angle psi_V = (3.32 +- 0.09) degree. Z^2_G and psi_P are fairly consistent with those previously published. We also evaluate the impact on the eta' gluonium content determination of future experimental improvements of the eta' branching ratios and decay width.Comment: 13 pages, 7 figures to submit to JHE

    Search for the K_S -> e+e- decay with the KLOE detector

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    We present the result of a direct search for the decay K_S -> e+e-, obtained with a sample of e+e- -> phi -> K_S K_L events produced at DAFNE, the Frascati phi-factory, for an integrated luminosity of 1.9 fb^-1. The search has been performed using a pure K_S beam tagged by the simultaneous detection of a K_L interaction in the calorimeter. Background rejection has been optimized by using both kinematic and particle identification cuts. We find BR(K_S -> e+e-) < 9x10^-9 at 90% CL, which improves by an order of magnitude on the previous best limit.Comment: 13 pages, 11 figures, submitted to Physics Letters

    Study of the Decay phi --> eta pi0 gamma with the KLOE detector

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    In a sample of 5.3x10^7 phi-decays observed with the KLOE detector at the Frascati phi-factory Dafne we find 605 eta pi0 gamma events with eta --> gamma\gamma and 197 eta pi0 gamma events with eta --> pi+ pi- pi0. The decay phi --> eta pi0 gamma is dominated by the process phi --> a0 gamma. From a fit to the eta pi0 mass spectrum we find BR(phi --> ao(980) gamma)= (7.4 +- 0.7)x10^-5.Comment: 12 pages, 6 figures, submitted to Phys.Lett.
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