Saponins and Polyphenols from <i>Fadogia ancylantha</i> (Makoni Tea)

Three new saponins (1−3) and a known saponin, together with four known polyphenolic compounds, have been isolated from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1−3 were established by analysis of their spectroscopic data. Both an ethanol−water extract of F. ancylantha and its phenolic constituents showed significant free-radical-scavenging and antimicrobial activities. No cytotoxicity, as evaluated by analysis of hypodiploid nuclei in HUVEC cells using propidium iodide staining, was observed for either the plant crude extract or its constituents

FTIR spectra of P raw material, formulations F5-F6 and Zn-alginate blank beads F.

<p>FTIR spectra of P raw material, formulations F5-F6 and Zn-alginate blank beads F.</p

Release profiles of: P raw material hosted into DR^® capsules (square) compared with optimized F6/DR^® final dosage form (triangle).

Mean ± SD; (n = 3).</p

Composition, actual drug content, encapsulation efficiency, mean diameter and sphericity coefficient of optimized manufactured by prilling.

<p>Composition, actual drug content, encapsulation efficiency, mean diameter and sphericity coefficient of optimized manufactured by prilling.</p

Release profiles of P from: raw material, square; # F2, diamond; # F4, circle and #F6, triangle.

<p>Mean ± SD; (n = 6).</p