32 research outputs found

    The Hubs of Transformation Dictated by the Innovation Wave: Boston as a Case Study: Exploring How Design is Emerging as an Essential Feature in the Process of Laboratorization of Cities

    Get PDF
    Cities have become nodes of global networks, standing at the intersection points of the flows of capital, goods, workers, businesses, and travelers, making them spots where innovation, progress and economic development occur. Design emerges as an essential feature in this process, which this manuscript defines as the ‘laboratorization of cities’, a cutting-edge urban development paradigm that emphasizes cities as dynamic laboratories for innovation and experimentation. This study explored the spatial hubs of transformation within the knowledge economy, providing an overview of the current models of innovation spaces before focusing on the innovation district of one of the cities that are riding the innovation wave, namely Boston, USA. Information was gathered from observations, exploratory interviews with key stakeholders, and on-desk data. The study has significant implications, spanning from informing global urban development strategies to impacting regional economic planning and national policies. It provides valuable insights into how design, innovation, and urban development are interconnected, potentially reshaping how cities and regions approach their growth in the current knowledge-driven era. Useful lessons can be drawn from the case study analysis, allowing to define valuable tools for policymakers, a forward-looking perspective on the future of the laboratorization of cities and the evolving role of design, providing a roadmap for cities aiming to position themselves as global innovation hubs

    SUBTIPOS DE CÂNCER DE PELE E OS IMPACTOS DOS FATORES DE RISCO

    Get PDF
    O câncer de pele é caracterizado por uma divisão anormal das células, podendo ocorrer em qualquer região do corpo, que, se acometida, apresenta enrugamento, mudanças na pigmentação e perda de elasticidade. Os cânceres de pele são divididos em melanoma e não melanoma, subdivididos em Carcinoma Basocelular (CBC) e Carcinoma Espinocelular (CEC). Assim, o objetivo do trabalho foi conhecer as características próprias de cada tumor, a fim de saber identificar quaisquer alterações que possam estar relacionadas a essa neoplasia e relacionar a mesma com fatores de risco, diagnóstico, tratamento e prevenção. O Carcinoma Basocelular tem origem nas células basais e possui baixa agressividade, já o Carcinoma Espinocelular manifesta-se nas células escamosas, podendo evoluir caso não haja tratamento. O tipo Melanoma possui a maior taxa de mutação, sendo o mais agressivo e raro, com alto poder de metástase. Os raios ultravioletas do tipo A e B são o principal fator etiológico da neoplasia, associados às atividades ao ar livre sem proteção ou dispositivos de bronzeamento artificial, bem como o esgotamento da camada de ozônio. As alterações na pele podem ser verificadas através do teste ABCDE, sendo o diagnóstico feito pelo médico  por meio de exames clínicos, laboratoriais ou radiológicos. O uso de filtros solares diariamente constitui a principal forma de prevenção

    High Specificity of Quantitative Methylation-Specific PCR Analysis for MGMT Promoter Hypermethylation Detection in Gliomas

    Get PDF
    Normal brain tissue from 28 individuals and 50 glioma samples were analyzed by real-time Quantitative Methylation-Specific PCR (QMSP). Data from this analysis were compared with results obtained on the same samples by MSP. QMSP analysis demonstrated a statistically significant difference in both methylation level (P = .000009 Mann Whitney Test) and frequencies (P = .0000007, Z-test) in tumour samples as compared with normal brain tissues. Although QMSP and MSP showed similar sensitivity, the specificity of QMSP analysis was significantly higher (93%; CI95%: 84%–100%) as compared with MSP (64%; 95%CI: 46%–82%). Our results suggest that QMSP analysis may represent a powerful tool to identify glioma patients that will benefit from alkylating agents chemotherapy

    An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children

    Get PDF
    Since the beginning of 2020, a remarkably low incidence of respiratory virus hospitalizations has been reported worldwide. We prospectively evaluated 587 children, aged <12 years, admitted for respiratory tract infections from 1 September 2021 to 15 March 2022 in four Italian pediatric hospitals to assess the burden of respiratory viruses during the COVID-19 pandemic in Italy. At admission, a Clinical Respiratory Score was assigned and nasopharyngeal or nasal washing samples were collected and tested for respiratory viruses. Total admissions increased from the second half of October 2021 to the first half of December 2021 with a peak in early November 2021. The respiratory syncytial virus (RSV) incidence curve coincided with the total hospitalizations curve, occurred earlier than in the pre-pandemic years, and showed an opposite trend with respect to the incidence rate of SARS-CoV-2. Our results demonstrated an early peak in pediatric hospitalizations for RSV. SARS-CoV-2 may exhibit a competitive pressure on other respiratory viruses, most notably RSV

    RACK1 Is a Ribosome Scaffold Protein for β-actin mRNA/ZBP1 Complex

    Get PDF
    In neurons, specific mRNAs are transported in a translationally repressed manner along dendrites or axons by transport ribonucleic-protein complexes called RNA granules. ZBP1 is one RNA binding protein present in transport RNPs, where it transports and represses the translation of cotransported mRNAs, including β-actin mRNA. The release of β-actin mRNA from ZBP1 and its subsequent translation depends on the phosphorylation of ZBP1 by Src kinase, but little is known about how this process is regulated. Here we demonstrate that the ribosomal-associated protein RACK1, another substrate of Src, binds the β-actin mRNA/ZBP1 complex on ribosomes and contributes to the release of β-actin mRNA from ZBP1 and to its translation. We identify the Src binding and phosphorylation site Y246 on RACK1 as the critical site for the binding to the β-actin mRNA/ZBP1 complex. Based on these results we propose RACK1 as a ribosomal scaffold protein for specific mRNA-RBP complexes to tightly regulate the translation of specific mRNAs

    Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

    Get PDF
    Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

    Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

    Get PDF
    Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

    Ultralight vector dark matter search using data from the KAGRA O3GK run