Expected Lipschitz-Killing curvatures for spin random fields and other non-isotropic fields

Spherical spin random fields are used to model the Cosmic Microwave Background polarization, the study of which is at the heart of modern Cosmology and will be the subject of the LITEBIRD mission, in the 2030s. Its scope is to collect datas to test the theoretical predictions of the Cosmic Inflation model. In particular, the Minkowski functionals, or the Lipschitz-Killing curvatures, of excursion sets can be used to detect deviations from Gaussianity and anisotropies of random fields, being fine descriptors of their geometry and topology. In this paper we give an explicit, non-asymptotic, formula for the expectation of the Lipshitz-Killing curvatures of the excursion set of the real part of an arbitrary left-invariant Gaussian spin spherical random field, seen as a field on $SO(3)$. Our findings are coherent with the asymptotic ones presented in Carr\'on Duque, J. et al. "Minkowski Functionals in $SO(3)$ for the spin-2 CMB polarisation field", Journal of Cosmology and Astroparticle Physics (2024). We also give explicit expressions for the Adler-Taylor metric, and its curvature. We obtain such result as an application of a general formula that applies to any nondegenerate Gaussian random field defined on an arbitrary three dimensional compact Riemannian manifold. The novelty is that the Lipschitz-Killing curvatures are computed with respect to an arbitrary metric, possibly different than the Adler-Taylor metric of the field.Comment: 33 page

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Small scale behavior of monochromatic random waves on surfaces

In this thesis we provide asymptotic results for the nodal length of monochromatic random waves on surfaces, restricted to shrinking balls in small scale regime following the Small Scale CLT’s result due to Dierickx, Nourdin, Peccati and Rossi in 2019

Limit theorems for pp-domain functionals of stationary Gaussian fields

Fix an integer $p\geq 1$ and refer to it as the number of growing domains. For each $i\in\{1,\ldots,p\}$, fix a compact subset $D_i\subseteq\mathbb R^{d_i}$ where $d_1,\ldots,d_p\ge 1$. Let $d= d_1+\dots+d_{p}$ be the total underlying dimension. Consider a continuous, stationary, centered Gaussian field $B=(B_x)_{x\in \mathbb R^d}$ with unit variance. Finally, let $\varphi:\mathbb R \rightarrow \mathbb R$ be a measurable function such that $\mathrm E[\varphi(N)^2]<\infty$ for $N\sim N(0,1)$. In this paper, we investigate central and non-central limit theorems as $t_1,\ldots,t_p\to\infty$ for functionals of the form $$Y(t_1,\dots,t_p):=\int_{t_1D_1\times\dots \times t_pD_p}\varphi(B_{x})dx.$$ Firstly, we assume that the covariance function $C$ of $B$ is {\it separable} (that is, $C=C_1\otimes\ldots\otimes C_{p}$ with $C_i:\mathbb R^{d_i}\to\mathbb R$), and thoroughly investigate under what condition $Y(t_1,\dots,t_p)$ satisfies a central or non-central limit theorem when the same holds for $\int_{t_iD_i}\varphi(B^{(i)}_{x_i})dx_i$ for at least one (resp. for all) $i\in \{1,\ldots,p\}$, where $B^{(i)}$ stands for a stationary, centered, Gaussian field on $\mathbb R^{d_i}$ admitting $C_i$ for covariance function. When $\varphi$ is an Hermite polynomial, we also provide a quantitative version of the previous result, which improves some bounds from A. Reveillac, M. Stauch, and C. A. Tudor, Hermite variations of the fractional brownian sheet, Stochastics and Dynamics 12 (2012). Secondly, we extend our study beyond the separable case, examining what can be inferred when the covariance function is either in the Gneiting class or is additively separable

Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes

Background. Kidney dysfunction is a strong predictor of end-stage renal disease and cardiovascular (CV) events. The main goal was to study the clinical correlates of diabetic kidney disease in a large cohort of patients with type 2 diabetes mellitus (T2DM) attending 236 Diabetes Clinics in Italy.Methods. Clinical data of 120 903 patients were extracted from electronic medical records by means of an ad hoc-developed software. Estimated glomerular filtration rate (GFR) and increased urinary albumin excretion were considered. Factors associated with the presence of albuminuria only, GFR &lt; 60 mL/min/1.73 m(2) only or both conditions were evaluated through multivariate analysis.Results. Mean age of the patients was 66.6 +/- 11.0 years, 58.1% were male and mean duration of diabetes was 11.1 +/- 9.4 years. The frequency of albuminuria, low GFR and both albuminuria and low GFR was 36.0, 23.5 and 12.2%, respectively. Glycaemic control was related to albuminuria more than to low GFR, while systolic and pulse pressure showed a trend towards higher values in patients with normal kidney function compared with those with both albuminuria and low GFR. Multivariate logistic analysis showed that age and duration of disease influenced both features of kidney dysfunction. Male gender was associated with an increased risk of albuminuria. Higher systolic blood pressure levels were associated with albuminuria, with a 4% increased risk of simultaneously having albuminuria and low GFR for each 5 mmHg increase.Conclusions. In this large cohort of patients with T2DM, reduced GFR and increased albuminuria showed, at least in part, different clinical correlates. A worse CV risk profile is associated with albuminuria more than with isolated low GFR