Floras del Mioceno de Patagonia austral, evidencias palinológicas en el noroeste de Santa Cruz

La historia evolutiva de las plantas durante el Cenozoico ha sido objeto de diversas contribuciones paleontológicas que enriquecieron el conocimiento científico acerca de las floras y los climas que afectaron y modificaron el paisaje patagónico en el pasado geológico reciente. La paleopalinología en particular se destaca como disciplina para las reconstrucciones paleoambientales mediante el estudio de la materia orgánica fósil y, en especial, los palinomorfos. Esta contribución intenta reconstruirla paleoflora y paleoambientes miocenos en la región del Lago Posadas/Meseta Belgrano, al noroeste de la provincia de Santa Cruz, mediante el análisis palinológico. Con este fin, se analizaron en microscopía óptica 10 muestras fértiles provenientes de la Formación El Chacay. Las asociaciones recuperadas muestran un predominio de las formas continentales (esporas, polen y algas de agua dulce) sobre las marinas (acritarcas, dinoquistes y prasinofitas). Entre las formas continentales dominan los granos de polen asignables a elementos de bosque como las notofagáceas (Nothofagidites spp.), araucariáceas (Araucariacites australis) y podocarpáceas (Podocarpidites spp.), elementos de vegetación abierta como las amarantáceas, anacardiáceas,poáceas, restionáceas y efedráceas (Chenopodipollis chenopodiaceoides, Striatricolporites gamerroi, Graminiidites sp., Milfordia argentina y Equisetosporites claricristatus) y esporas de helechos de cyatheáceas,dicksoniáceas y polypodiáceas(Cyathidites spp., Cyatheacidites annulatus y Laevigatosporites ovatus), que habrían conformado el sotobosque. Las variaciones cuantitativas de estos palinomorfos sugieren una microflora integrada por bosques, vegetación abierta y plancton asociada con la depositación de un ambiente marino costero a estuárico. La presencia de formas polínicas como Mutisiapollis viteauensis, Baumanipollis variaperturatus y Rhoipites cienaguensis permiten ubicar esta microflora en el entorno del Mioceno temprano.Fil: Tapia, Mariano Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Palazzesi, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Barreda, Viviana Dora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Ottone, Eduardo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Cuitiño, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaXXXVII Jornadas Argentinas de BotánicaTucumánArgentinaSociedad Argentina de Botánic

Personality Characteristics and the Mediating Variables that Lead to Success or Failure of Substance Use Disorder Treatments: An All-Pathways Assessment

The purpose of this study is to examine the All-Pathways approach as an effective modality in SUD treatments. Further, this study aims to identify personality characteristics that may predict an individual’s success rate in different SUD recovery programs. Despite the recent trend in the All-Pathways approach, there is a lack of research to substantiate this therapeutic modality. The All-Pathways approach is based on the “Client-centered” model of psychotherapy developed by Carl Rogers. The research findings by Deane et al. (2012) provide evidence that personality traits, such as self-forgiveness, can predict success or failure in a Twelve-step program. Effective treatments vary and are often a combination of approaches. Despite this, there is not currently a strategy in determining appropriateness of treatment modalities to the individual seeking treatment, which can result in early termination of the program. The end goal of this study is to develop a tool that can predict which SUD recovery program is the best match based on personality traits. The primary aim at first was to create a survey that could identify what these personality characteristics are. The completed survey will use the following scales: The Life Engagement Test scale, Heartland Forgiveness scale, Centrality of Religiosity scale, and the AMBI scale. Participants will be self-selected volunteers and surveys will be administered to participants online using Qualtrics. Data will be analyzed using SPSS once sufficient data has been collected

The Give and Take Game: Analysis of a Resource Sharing Game

We analyse Give and Take, a multi-stage resource sharing game to be played between two players. The payoff is dependent on the possession of an indivisible and durable resource, and in each stage players may either do nothing or, depending on their roles, give the resource or take it. Despite these simple rules, we show that this game has interesting complex dynamics. Unique to Give and Take is the existence of multiple Pareto optimal profiles that can also be Nash equilibria, and a built-in punishment action. This game allows us to study cooperation in sharing an indivisible and durable resource. Since there are multiple strategies to cooperate, Give and Take provides a base to investigate coordination under implicit or explicit agreements. We discuss its position in face of other games and real world situations that are better modelled by it. The paper presents an in-depth analysis of the game for the range of admissible parameter values. We show that, when taking is costly for both players, cooperation emerges as players prefer to give the resource

Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Contains fulltext : 218279.pdf (Publisher’s version ) (Open Access)Patients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications (ITDs) have poor outcomes, in particular AML with a high (>/=0.5) mutant/wild-type allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined 4 distinct FLT3-ITD genotypes based on the ITD AR and the NPM1 mutational status. In this retrospective exploratory study, we investigated the prognostic and predictive impact of the NPM1/FLT3-ITD genotypes categorized according to the 2017 ELN risk groups in patients randomized within the RATIFY trial, which evaluated the addition of midostaurin to standard chemotherapy. The 4 NPM1/FLT3-ITD genotypes differed significantly with regard to clinical and concurrent genetic features. Complete ELN risk categorization could be done in 318 of 549 trial patients with FLT3-ITD AML. Significant factors for response after 1 or 2 induction cycles were ELN risk group and white blood cell (WBC) counts; treatment with midostaurin had no influence. Overall survival (OS) differed significantly among ELN risk groups, with estimated 5-year OS probabilities of 0.63, 0.43, and 0.33 for favorable-, intermediate-, and adverse-risk groups, respectively (P < .001). A multivariate Cox model for OS using allogeneic hematopoietic cell transplantation (HCT) in first complete remission as a time-dependent variable revealed treatment with midostaurin, allogeneic HCT, ELN favorable-risk group, and lower WBC counts as significant favorable factors. In this model, there was a consistent beneficial effect of midostaurin across ELN risk groups

Safety and efficacy of COVID-19 vaccines in patients on dialysis: a multicentre cohort study in Italy

Background The aim of this study was to evaluate the efficacy and safety of COVID-19 vaccines in patients undergoing haemodialysis in Italy compared to the general population.Methods In this cohort study, 118 dialysis centres from 18 Italian Regions participated. Individuals older than 16 years on dialysis treatment for at least 3 months, who provided informed consent were included. We collected demographic and clinical information, as well as data on vaccination status, hospitalisations, access to intensive care units and adverse events. We calculated the incidence, hospitalisation, mortality, and fatality rates in the vaccinated dialysis cohort, adjusted for several covariates. The incidence rates of infection in the dialysis cohort and the general population were compared through Standardised Incidence Rate Ratio.Results The study included 6555 patients vaccinated against SARS-CoV-2 infection according to the schedule recommended in Italy. Between March 2021 and May 2022, there were 1096 cases of SARS-CoV-2 infection, with an incidence rate after completion of the three-dose vaccination cycle of 37.7 cases per 100 person-years. Compared to the general population, we observed a 14% reduction in the risk of infection for patients who received three vaccine doses (Standardised Incidence Rate Ratio: 0.86; 95% Confidence Interval: 0.81-0.91), whereas no statistically significant differences were found for COVID-19-related hospitalisations, intensive care unit admissions or death. No safety signals emerged from the reported adverse events.Conclusions The vaccination program against SARS-CoV-2 in the haemodialysis population showed an effectiveness and safety profile comparable to that seen in the general population