Оцінка якості надання медичної допомоги хворим стаціонарних відділень Сумської ЦРКЛ на основі цільового соціологічного опитування

У загальносвітових тенденціях стосовно покращання якості медичної допомоги превалює залучення механізмів безпосереднього впливу у самому закладі охорони здоров’я через систематичне оцінювання роботи персоналу та вивчення думки пацієнтів. Мета: визначити оцінку задоволеності пацієнтів стаціонарних відділень якістю медичної допомоги на основі цільового соціологічного опитування

A New Synthesis of α-Amino Acid Thioesters by Pummerer Reaction of 3-Substituted-4-sulfinyl-β-sultams

α-Amino acid thioesters were synthesized by the Pummerer reaction of 3-substituted-4-sulfinyl-β-sultams with TFAA. The 3-substituted-4-sulfinyl-β-sultams were prepared from the corresponding β-sultams by sulfenylation with diphenyl disulfide followed by m-CPBA oxidation. Diastereoselective synthesis of β-sultams by 1,3-asymmetric induction in [2 + 2] cycloaddition of a sulfene intermediate and chiral imines in solution-phase was studied, and it was found that N-alkylimines gave better diastereoselectivities than N-aralkylimines. The use of imines derived from (R)- and (S)-α-methylbenzylamine followed by separation of the major and minor diastereomers gave enantiopure 3-substituted-N-methylbenzyl-β-sultams. These β-sultams were then converted to N-methylbenzyl-α-amino acid thioesters via sulfenylation and Pummerer rearrangement with high or complete retention of configuration

Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide Using a Radical Cascade

Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations

A New Synthesis of α-Amino Acid Thioesters by Pummerer Reaction of 3-Substituted-4-sulfinyl-β-sultams

α-Amino acid thioesters were synthesized by the Pummerer reaction of 3-substituted-4-sulfinyl-β-sultams with TFAA. The 3-substituted-4-sulfinyl-β-sultams were prepared from the corresponding β-sultams by sulfenylation with diphenyl disulfide followed by m-CPBA oxidation. Diastereoselective synthesis of β-sultams by 1,3-asymmetric induction in [2 + 2] cycloaddition of a sulfene intermediate and chiral imines in solution-phase was studied, and it was found that N-alkylimines gave better diastereoselectivities than N-aralkylimines. The use of imines derived from (R)- and (S)-α-methylbenzylamine followed by separation of the major and minor diastereomers gave enantiopure 3-substituted-N-methylbenzyl-β-sultams. These β-sultams were then converted to N-methylbenzyl-α-amino acid thioesters via sulfenylation and Pummerer rearrangement with high or complete retention of configuration

Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide Using a Radical Cascade

Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations

Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide Using a Radical Cascade

Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations

Development of Novel Diastereoselective Alkenylation of Enolates Using Alkenylselenonium Salts

A novel alkenylation of enolates using alkenylselenonium salts is described. A reaction of lithium enolates, which were prepared in situ by the reaction of LiHMDS and carbonyl compounds, with alkenylselenonium salts gave the ethenylation products of carbonyl compounds in high yield. Diastereoselective alkenylation was also accomplished by the reaction of the enolates derived from N-acyl-1,3-oxazolidin-2-ones with the alkenylselenonium salt to afford good results (up to 92% yield and up to 95% de)

Stereospecific Syntheses of 5-Alkyl-3-ethoxy-2-((phenylchalcogeno)methylene)tetrahydrofurans

2-Ethoxy-4-(phenylchalcogeno)but-3-ynyl ketones 1−10 were reduced with LiBH4 in Et2O diastereoselectively to give 5-(phenylchalcogeno)pent-4-yn-1-ols 11−20. Treatment of the phenylchalcogen-substituted alkynyl alcohols 11−20 with t-BuOK in t-BuOH provided useful (Z)-2-((phenylchalcogeno)methylene)tetrahydrofurans 21−31 stereoselectively

Megastigmanes and Their Glucosides from the Whole Plant of <i>Sedum sarmentosum</i>

Two new megastigmanes, sarmentoic acid (1) and sarmentol A (2), and six new megastigmane glucosides, sedumosides A1 (3), A2 (4), A3 (5), B (6), C (7), and D (8), were isolated from the whole plant of Sedum sarmentosum together with eight known megastigmanes (9−16). The absolute stereostructures of 1−8 were elucidated on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method

7-<i>endo</i> Selective Aryl Radical Cyclization onto Enamides Leading to 3-Benzazepines: Concise Construction of a Cephalotaxine Skeleton

Bu3SnH-mediated radical cyclizations of 2-(2-bromophenyl)-N-ethenylacetamide gave 6-exo cyclization product 15 as the major product, whereas N-[2-(2-bromophenyl)ethyl]-N-ethenylamides gave almost exclusively 7-endo cyclization products. These results indicated that the position of the carbonyl group on enamide played an important role in deciding the course of the cyclization. The 7-endo selective cyclization was applied to concise construction of a cephalotaxine skeleton