Open Source Software and Technological Innovation: Competitive Issues

The new model of the products development and distribution represented by the open source movement has an important impact on the composition of the software market because it is a system alternative to the proprietary model. The antitrust analysis of the software market has to value, therefore, the strong effect of the open source development and distribution on the market contendibility and on the effectiveness to substitute the proprietary scheme

Toward a Euro Mediterranean tsunami warning system: The case of the February 12, 2007, Ml = 6.1 earthquake

UNESCO has made a commitment to the scientific community for the creation of the North East Atlantic and Mediterranean Tsunami Warning System (NEAMTWS). We wonder: "Is the European Seismological community ready to run an Euro Mediterranean tsunami warning system?" In this study we use the February 12, 2007 Ml = 6.1 earthquake, which occurred close to the epicenter of the 1755 Great Lisbon event, as a case study to verify and discuss our actual capability of alerting for a hypothetical tsunami. Starting from the available real‐time data and tools, we emulate an automatic real‐time processing to perform the source analyses needed for discriminating a tsunamigenic earthquake, and subsequently we evaluate the time shift between the release of results and the potential tsunami waterfront reaching the coasts

Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model

Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include an effective vaccine. Several strategies have assessed the virulence and immune response of Map strains that could be used as a vaccine. This study evaluates the degree of virulence, immune response, and protection of Argentinian strains of Map with different genotype in a murine model. Four local isolates (Cattle type) with different genotypes (analyzed by MIRU-VNTR and SSRs) were selected and evaluated in a virulence assay in BALB/c mice. This assay allowed us to differentiate virulent and low-virulence Map strains. The less virulent strains (1543/481 and A162) failed to induce a significant production of the proinflammatory cytokine IFNg, whereas the virulent strain 6611 established infection along with a proinflammatory immune response. On the other hand, the virulent strain 1347/498 was efficient in establishing a persistent infection, but failed to promote an important Th1 response compared with 6611 at the evaluated time. We selected the low-virulence strain 1543/498 as a live vaccine and the virulent strain 6611 as a live and inactivated vaccine in a protection assay in mice. Strain 1543/481 failed to protect the animals from challenge, whereas strain 6611, in its live and inactivated form, significantly reduced the CFUs count in the infected mice, although they had different immunological response profiles. The inactivated virulent strain 6611 is a potential vaccine candidate against paratuberculosis to be tested in cattle.Fil: Colombatti Olivieri, María Alejandra. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moyano, Roberto Damian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Travería, Gabriel Eduardo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Alvarado Pinedo, María Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Mon, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Gravisaco, Maria Jose Federica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; ArgentinaFil: Santangelo, María de la Paz. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romano, Maria Isabel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Educación en contextos de encierro. Los primeros pasos de un acompañamiento institucional

En el segundo semestre del año 2012, se llevaron a cabo las primeras acciones de un dispositivo de acompañamiento institucional, a través de la Dirección General de Educación de Jóvenes y Adultos, Coordinación E.C.E., destinado a todas las instituciones educativas de nivel primario y secundario que se desempeñan en contextos de encierro. Las mismas guardaron relación con el reconocimiento y el pleno ejercicio de derechos de los sujetos privados de libertad, siendo el que más ocupó, el “derecho a la educación”.Como problema Inicial, dificultades de índole pedagógica y administrativa importunaban la certificación de trayectos educativos de estudiantes en algunas instituciones, impidiendo garantizar la continuidad luego de recuperar la libertad, traduciéndose en una evidente fragmentación de las instituciones hacia el interior de la modalidad.Como objetivos generales nos propusimos trabajar con las instituciones educativas para que se recuperase la identidad institucional de la modalidad, el sentido de pertenencia que la escuela podría tener dentro del “encierro” reconociendo a la misma, como una opción organizativa y curricular que permitiera garantizar el derecho a la educación.Con respecto a la metodología se optó por una serie de acciones de apoyo en la construcción de las prácticas educativas en contextos de encierro, visualizando las condiciones que pudieran estar vulnerando los derechos educativos, así como las de posibilidad. Poniendo en tensión el logro de los objetivos planteados por la modalidad, entre ellos, garantizar el acceso, la permanencia y la terminalidad educativa. En relación a los resultados este trabajo nos permitió elaborar un diagnóstico de las instituciones educativas y avanzar en el abordaje de las problemáticas provenientes de la convivencia con el servicio penitenciario.Las acciones de fortalecimiento habilitaron espacios de negociación y reconocimiento que aún no se habían podido establecer con el Ministerio de Justicia y Derechos Humanos en nuestra jurisdicción

Cannabis caught between smoke and mirrors

Cannabis legalization advances across the country and social attitudes are changing. Public health experts see parallels with the tobacco industry-- and are concerned about kids exposed to cannabis advertisement

Computational modeling of the right ventricle in repaired tetralogy of Fallot, before and after pulmonary valve replacement

Postprint (published version

Insights into pet-based radiogenomics in oncology: an updated systematic review

Purpose: This study systematically reviews current evidence on radiogenomics applied to positron emission tomography (PET) imaging across oncological diseases. The primary objective is to evaluate how PET-based radiogenomics aids in understanding tumor biology, prognostic stratification, and clinical outcome prediction, while identifying methodological challenges in the field. Methods: A systematic review was conducted following PRISMA guidelines, focusing on English-language studies indexed in Scopus, PubMed, and Web of Science until October 31, 2024. Inclusion criteria targeted original research articles involving human oncology studies using radiomics and genomics in a comprehensive “omics” framework. Data extraction included patient cohorts, radiopharmaceuticals and statistical methods. Studies were assessed for methodological rigor and reporting quality according to radiomics quality scores (RQS 2.0). Results: Eighteen studies involving 1780 patients were included, with 75.8% focused on lung cancer. Most studies were retrospective (72.2%) and single-center (77.7%). The primary radiopharmaceutical was [18F]FDG (88.8%). Key findings demonstrated correlations between PET-derived radiomic features and genomic alterations, such as KRAS, EGFR, and TGFβ mutations in lung cancer, and prognostic biomarkers in other malignancies. However, systemic shortcomings, including limited external validation, low reproducibility, and inadequate harmonization, were prevalent. None of the studies exceeded 50% of the RQS maximum score. Conclusion: PET-based radiogenomics holds significant potential for advancing precision oncology by capturing tumor heterogeneity and improving prognostic stratification. However, methodological limitations, particularly regarding study design and data transparency, hinder its clinical applicability. Future research should prioritize multicentric designs, robust external validations, and enhanced standardization to fully realize the discipline’s potential

Fluid dynamics of right ventricular filling in the presence of pulmonary regurgitation: assessment using DNS and 4D Flow MRI

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