319 research outputs found
Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome
Diffuse Large B-Cell Lymphoma 18 Years After Bilateral Lacrimal Gland IgG4-Related Disease: Case Report and Literature Review
IgG4-related disease is a recently established clinical entity. The disease might serve as the background for later development of systemic lymphoma. This study aims to confirm the diagnosis of IgG4-related disease by re-staining lacrimal gland lesions diagnosed previously with low-grade lymphoma in a patient who developed systemic diffuse large B-cell lymphoma (DLBCL) 18 years later. A 53-year-old man developed bilateral lacrimal gland swelling and right submandibular gland swelling and was diagnosed by excision as low-grade lymphoma. In follow-up, positron emission tomography showed high uptake in the median hyoid 11 years later but no malignancy was detected by laryngeal submucosal biopsy. He was well with no treatment until 18 years later when he had palatal swelling and was diagnosed with DLBCL by oral floor biopsy. He had systemic lymphadenopathy, infiltration in paranasal sinuses, hypopharynx, small intestine, kidney, and prostate. He underwent 8 courses of R-CHOP and 3 courses of high-dose methotrexate and achieved complete remission with no relapse for 1 year thereafter. Re-immunostaining of paraffin blocks of bilateral lacrimal gland lesions showed IgG and IgG4-positive lymphocytes and plasma cells among lymphoid follicles separated by fibrous bundles, with 10 or more IgG4-positive cells in high-power field. The IgG4/IgG-positive cell ratio was 100% and the number of κ chain-positive cells and λ chain-positive cells was the same. The bilateral lacrimal lesions were thus re-diagnosed as IgG4-related disease. In conclusion, systemic DLBCL occurred approximately 20 years after lacrimal gland IgG4-related disease. Literature review revealed 12 patients with IgG4-related disease, including the present patient, who later developed lymphoma in the other organs
Studies on the MIKOF Equation Environmental Therapy by Famous Water for Biology-Living Body (Fourth Report)
Nondestructive structure test of cam-shaft using both eddy current and X-rays
The cam-shaft for the internal-combustion engine needs to be chilled at the foundry stage to rise the cam hardness, but unexpected chilled structures could occur on the sensor plate surface. If chilled structures exist on the sensor plate, a grinding tool may break when grinding sensor plate, or the specified shape may be unable to be produced due to resistance arising from the hyper-hardness of the chilled structures. For this reason, developing an inspection technique and a device for detecting unnecessary chilled structures before grinding the cam-shaft and for determining the rejection and removal of cam-shafts with chilled structures detected was necessary. This article reports on a recently developed nondestructive method using an eddy current test and X-rays to accurately detect chilled structures on a cam-shaft sensor plate. © (2012) Trans Tech Publications, Switzerland
微生物の代謝調節機構に関する遺伝生化学的研究
金沢大学医学部研究課題/領域番号:X00050----838034, 研究期間(年度)1973出典:研究課題「微生物の代謝調節機構に関する遺伝生化学的研究 」課題番号 X00050----838034(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X00050----838034/)を加工して作
Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue
The aim of this study was to investigate the effect of dietary lemon polyphenols on high-fat diet-induced obesity in mice, and on the regulation of the expression of the genes involved in lipid metabolism to elucidate the mechanisms. Mice were divided into three groups and fed either a low fat diet (LF) or a high fat diet (HF) or a high fat diet supplemented with 0.5% w/w lemon polyphenols (LP) extracted from lemon peel for 12 weeks. Body weight gain, fat pad accumulation, the development of hyperlipidemia, hyperglycemia, and insulin resistance were significantly suppressed by lemon polyphenols. Supplementation with lemon polyphenols also significantly up-regulated the mRNA level of the peroxisome proliferator activated receptor-α (PPARα) compared to the LF and HF groups in the liver. Furthermore, the mRNA level of acyl-CoA oxidase (ACO) was up-regulated in the LP group compared to the LF group, but not HF group in the liver, and was also significantly increased in the epididymal white adipose tissue. Thus, feeding with lemon polyphenols suppressed body weight gain and body fat accumulation by increasing peroxisomal β-oxidation through up-regulation of the mRNA level of ACO in the liver and white adipose tissue, which was likely mediated via up-regulation of the mRNA levels of PPARα
アデニンおよびアデノシンによる酵素合成抑制作用
研究課題/領域番号:X46040-----90135, 研究期間(年度): 1971出典:研究課題「アデニンおよびアデノシンによる酵素合成抑制作用」課題番号 X46040-----90135
(KAKEN:科学研究費助成事業データベース(国立情報学研究所))
(https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-X46040-----90135/)を加工して作成金沢大学医学部research repor
TNP-470 Suppresses the Tumorigenicity of HT1080 Fibrosarcoma Tumor Through the Inhibition of VEGF Secretion From the Tumor Cells
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer. TNP-470, a systemic analogue
of fumagillin, is an angiogenesis inhibitor capable of suppressing the tumorigenicity in several animal models even though
the mechanisms of action have not been completely clarified. In the current study, we investigated the effects of TNP-470
on human fibrosarcoma cells in vivo and in vitro. The administration of TNP-470 could suppress the tumorigenicity of
HT1080 fibrosarcoma tumor. The conditioned medium from HT1080 fibrosarcoma cells treated with TNP-470 inhibited
the proliferation and migration of human endothelial cell line, HUVEC and ECV304. The concentration of VEGF in the
conditioned medium from HT1080 cells treated with TNP-470 was lower than that of the cells without TNP-470 treatment,
indicating that TNP-470 downregulates the secretion of VEGF from HT1080 cells. These findings strongly suggest that the
direct action of TNP-470 on sarcoma cells inhibits angiogenesis through the downregulation of VEGF secretion and this
angiogenesis suppression resulted in the inhibition of tumorigenicity of HT1080 fibrosarcoma tumo
Development of three-dimensional reconstruction system based on the computer graphics technique for the three-dimensional bone histomorphometry
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