23 research outputs found

    FAIRENESS ON DECISION-MAKING PROCESS OF MANAGEMENT POLICY FOR HIGH-LEVEL RADIOACTIVE WASTE AND SITING OF REPOSITORY IN FRANCE

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    The purpose of our study is to estimate procedural fairness and distributive fairness of past decision-making process of the management policy for high‒level radioactive waste (HLW) and siting of repository in France. We conducted normative analysis by document review and interview survey with CLIS members and a sociologist participated in the public debate on HLW management policy in 2005 by CNDP. The results show that prior clarification when and how decision‒making of HLW management policy and siting of repository will be carried out in the step‒wise approach is important to enhance the legitimacy of the process. With regard to distributive fairness between generations, it is important to carefully consider responsibility of current generation and decision right of future generation in terms of equity and equality in the fair decision‒making process, because HLW management policy might depend on concept of distributive fairness between generations. It is necessary to carefully debate both interregional distributive fairness of negative legacy and economical distributive fairness in the fair decision‒making process, because they are inextricably linked together.本研究は文部科学省科学研究費基盤B(課題番号24402042,研究代表者 広瀬幸雄教授)の補助を受けて実施された

    Public acceptance of nuclear waste disposal sites: a decision-making process utilising the ‘veil of ignorance’ concept

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    Abstract This study demonstrates that a decision-making process utilising ‘the veil of ignorance’ concept, defined in process terms as beginning from a blank slate encompassing the entire country as potential sites and shortlisting candidate sites based on scientific (geological) safety, promotes public acceptance of siting a repository for the geological disposal of high-level radioactive waste and fosters procedural fairness. A hypothetical scenario experiment was conducted in Japan, manipulating the site selection process by setting two conditions—one being the application/proposal condition that the Japanese government currently employs, such as an application by municipalities or a proposal by the government, and the other being the veil of ignorance condition, in which multiple candidate areas are selected from a blank slate for the entire land area based purely on geological factors. Three stages of acceptance were presumed—at the level of general management policy, the site selection process itself with a specified decision policy, and the siting of a repository in their area of residence. Two hypotheses were tested: (a) the veil of ignorance condition will be evaluated as a more acceptable and fairer procedure and will engender increased national consensus than the application/proposal condition at the site selection and repository siting stages, and (b) procedural fairness and national consensus will impact acceptance at each stage; these variables at each stage help shape the same variables in the next stage. The results supported these hypotheses. This study discusses the importance of the site selection process, beginning where any de facto site can be a candidate and shortlisting the candidate sites based on scientific criteria

    Structural Basis of Homology-Directed DNA Repair Mediated by RAD52

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    Summary: RAD52 mediates homologous recombination by annealing cDNA strands. However, the detailed mechanism of DNA annealing promoted by RAD52 has remained elusive. Here we report two crystal structures of human RAD52 single-stranded DNA (ssDNA) complexes that probably represent key reaction intermediates of RAD52-mediated DNA annealing. The first structure revealed a “wrapped” conformation of ssDNA around the homo-oligomeric RAD52 ring, in which the edges of the bases involved in base pairing are exposed to the solvent. The ssDNA conformation is close to B-form and appears capable of engaging in Watson-Crick base pairing with the cDNA strand. The second structure revealed a “trapped” conformation of ssDNA between two RAD52 rings. This conformation is stabilized by a different RAD52 DNA binding site, which promotes the accumulation of multiple RAD52 rings on ssDNA and the aggregation of ssDNA. These structures provide a structural framework for understanding the mechanism of RAD52-mediated DNA annealing. : Biomolecules; Molecular Genetics; Structural Biology Subject Areas: Biomolecules, Molecular Genetics, Structural Biolog
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