702 research outputs found

    СРАВНИТЕЛЬНАЯ ОЦЕНКА ИСПОЛЬЗОВАНИЯ ЗРЕЛЫХ И НЕЗРЕЛЫХ ЗАРОДЫШЕЙ ЯРОВОЙ ТВЕРДОЙ ПШЕНИЦЫ В КУЛЬТУРЕ IN VITRO

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    Исследованы процессы индукции каллусогенеза различных генотипов яровой твердой пшеницы. Установлена генотипическая зависимость частоты морфогенеза. Показано, что эффективность процесса и тип каллуса обусловлены выбранным эксплантом. Установлено, что наибольшим морфогенетическим потенциалом обладают каллусы из незрелых зародышей. У морфогенетических линий, полученных из зрелых зародышей, процесс органогенеза не достигает организменного уровня, а заканчивается образованием корней (ризогенезом)

    Spiritual and moral foundations of craft profession training

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    The relevance of the problem under consideration stemmed from the need of revival of craft education system in Russia which focuses on training personnel for small handicraft enterprises, and it is also very important to identify, to preserve and to adapt it to the modern realities of pedagogical experience which was gained by the vocational education system in the past. The purpose of the article is to substantiate the need for development of spiritual, moral, organizational and pedagogical foundations of craft vocational education development in Russia theoretically and methodologically. The central approach to the investigation of this problem is the study and generalization of pedagogical experience which makes it possible to substantiate the tendencies of formation of a new type of vocational education in Russia. The result of the study was the substantiation of the key qualities of a master craftsman as a creative thinker and craft labour as a man-making system of knowledge and practical experience forming “multidimensional human integrity”. The statement that modern craft education should take into account the productive and transforming essence of a person as fully as possible, and thus, it should be acmeologically oriented can be considered the key conclusion. The materials of the article can be useful to practitioners and vocational education scientists, teachers and postgraduate students who are interested in the development of teaching system and personnel training system. © 2018 by the authors

    Smoking as a medical and social problem among students of Kursk State Medical University

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    A study was conducted among smoking students of FGBOU VO KSMU. It was revealed that half of the respondents have smoking parents; some of the respondents have chronic or smoking-related diseases, the number and severity of which is directly dependent on the length of smoking; most of the respondents would like to get rid of nicotine dependence.Проведено исследование среди курящих студентов ФГБОУ ВО КГМУ. Выявлено, что половина респондентов имеет курящих родителей; часть опрошенных имеет хронические или ассоциированные с курением заболевания, количество и тяжесть которых находится в прямой зависимости от стажа курения; большинство респондентов хотели бы избавиться от никотиновой зависимости

    Management of patients with hyperglycemia (diabetes mellitus). Management of patients with hypoglycemic states

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    methodical recommendationsThe methodological recommendations outline the issues of diagnosis and differential diagnosis of carbohydrate metabolism disorders, algorithms for the treatment of hyperglycemia, specific diabetes, and hypoglycemic states

    Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

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    Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods. The study included 86 patients with CAD, including 35 with moderate atherosclerotic lesions of the coronary arteries (CA) (SYNTAX Score ≤22), 22 with severe (SYNTAX Score of 23-31 pints), 29 with extremely severe (SYNTAX Score ≥32). As a comparison group, 52 patients with heart defects were examined. During an elective surgical intervention, adipose tissue (AT) samples were obtained for subsequent cultivation and determination of PAI-1 gene expression and PAI-1 secretion in AT supernatants of various localizations. Statistical analysis was performed using Statistica 10.0.Results. In CAD, PAI-1 production in all three types of AT and plasma PAI-1 concentration were increased compared with patients with heart defects. Epicardial AT (EAT) in CAD was characterized by the maximum levels of expression and secretion of PAI-1 relative to patients with heart defects and subcutaneous and perivascular (PVAT) fat depots. Moderate coronary involvement (adipose tissue <22) is characterized by the lowest expression and secretion of PAI-1 in all types of AT and plasma concentration of PAI-1. Direct correlations of PAI-1 expression and secretion in EAT and PVAT and plasma PAI-1 level with its secretion in EAT in patients with CAD and heart defects were revealed. A direct correlation between the plasma level of PAI-1 and its secretion in PVAT was found only in CAD.Conclusion. In CAD, there is not only an increase in the plasma PAI-1 level, but also an increase in the expression of PAI-1 gene and the secretion of PAI-1 in all three types of AT compared with patients with heart defects. PAI-1 expression and secretion in EAT, PAI-1 plasma level, and age are predictors of severe/extremely severe coronary involvement in CAD

    Statistics of Magnetic Fields for OB Stars

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    Based on an analysis of the catalog of magnetic fields, we have investigated the statistical properties of the mean magnetic fields for OB stars. We show that the mean effective magnetic field B{\cal B} of a star can be used as a statistically significant characteristic of its magnetic field. No correlation has been found between the mean magnetic field strength B{\cal B} and projected rotational velocity of OB stars, which is consistent with the hypothesis about a fossil origin of the magnetic field. We have constructed the magnetic field distribution function for B stars, F(B)F({\cal B}), that has a power-law dependence on B{\cal B} with an exponent of 1.82\approx -1.82. We have found a sharp decrease in the function F(B)F({\cal B})F for {\cal B}\lem 400 G that may be related to rapid dissipation of weak stellar surface magnetic fields.Comment: 22 pages, 7 figures, accepted Astronomy Letters, 2010, vol.36, No.5, pp.370-379, contact E-mail: [email protected]

    Optimization of blood pressure control, organ protection and metabolic disorders using a fixed-dose combination of lisinopril+amlodipine+rosuvastatin in hypertensive patients after COVID-19

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    Aim. To evaluate the potential of a fixed-dose combination of lisinopril+amlodipine+rosuvastatin (Equamer®) in achieving additional vascular protection in patients with hypertension and high pulse wave velocity (PWV) after severe and very severe coronavirus disease 2019 (COVID-19), complicated by bilateral multisegmental viral pneumonia, with the use of biological therapy, who had not previously received combination antihypertensive therapy.Material and methods. This 12-week open-label observational study included 30 patients with or without antihypertensive therapy. The patients underwent 24-hour blood pressure monitoring, applanation tonometry (determination of the augmentation index (AI) and central blood pressure (CBP)), PWV measurement, blood laboratory tests (lipid profile, fasting glucose, C-reactive protein, complete blood count, ferritin, fibrinogen, D-dimer, alanine aminotransferase, aspartate aminotransferase, creatinine, uric acid) before and after switch to a fixed-dose combination of lisinopril+amlodipine+rosuvastatin.Results. At baseline, the patients had an increase in office blood pressure (BP) up to 152,6/89,1 mm Hg. After prescribing a fixed-dose combination of lisinopril+amlodipine+rosuvastatin, there was a decrease in systolic blood pressure (SBP) by 15,8% and diastolic blood pressure (DBP) by 12,2%. According to 24-hour blood pressure monitoring, the decrease in SBP was 15%, DBP — by 9%, PWV — by 23,8%, AI — by 9%, CBP — by 12,4% (p<0,05 for all compared to baseline values). Vascular age (VA) was initially increased to 41,9 years with a chronological age of 35,03 years. After the end of therapy, there was a significant decrease in VA to 36,5 years, low-density lipoproteins by 46,8%, triglycerides by 16,8% and an increase in high-density lipoproteins by 10,7% (p<0,05 for all compared to baseline values). In addition, the levels of C-reactive protein, fibrinogen, D-dimer, glucose, and uric acid significantly decreased.Conclusion. The fixed-dosed combination of lisinopril+amlodipine+rosuvastatin provides better blood pressure control, improved vascular elasticity parameters (AI, PWV, CBP, decrease in VA), and also improves lipid and carbohydrate metabolism, reduces inflammation in patients with hypertension and hyperlipidemia after severe COVID-19

    МЕЗОПРОТЕРОЗОЙСКИЙ БАЗИТОВЫЙ МАГМАТИЗМ БАШКИРСКОГО МЕГАНТИКЛИНОРИЯ (ЮЖНЫЙ УРАЛ): ВОЗРАСТНЫЕ ОГРАНИЧЕНИЯ, ПЕТРОЛОГИЧЕСКИЕ И ГЕОХИМИЧЕСКИЕ ОСОБЕННОСТИ

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    Among the Riphean–Vendian dyke complexes of the basic composition, which intersect the Precambrian strata of the Bashkirian meganticlinorium (Southern Urals), one of the most common is the Kurgas gabbro-dolerite complex dated to the Early – Middle Riphean. This article presents the isotopic dating, petrological and geochemical features of the rocks belonging to the Kurgas complex. It gives the first description of the regional geochemical zoning that is reflected in a decrease in SiO2 contents from the north to the south along the Bashkirian meganticlinorium, and an increase in MgO contents in the same direction, which is attributed by the authors to an increase in the permeability of the crust to the south during opening of the Mashak riftogenic structure.New data on isotopic ages were obtained for the dyke that cuts the Satka formation of the Lower Riphean – 1318±10 (40Ar/39Ar), the intrusion in the exocontact zone of the Berdyaush rapakivi granite massif – 1349±11 Ma (U-Pb), and the andesite dyke among the metamorphic rocks of the Taratash complex – 1365.6±6.6 Ma (U-Pb). These ages, in combination with the previously obtained data, suggest that the complex formed during a rather long period of time (from 1385 to 1318 Ma, as a minimum), which corresponds to the beginning of the Middle Riphean. Isotopic U-Pb age of the dyke that cuts the contact zone of the Berdyaush massif, suggests that the major portion of the massif had already crystallized by that time and was exhumed into the shallow zone of brittle deformation.Среди рифейско-вендских дайковых комплексов основного состава, секущих докембрийские толщи Башкирского мегантиклинория (Южный Урал), одним из самых распространенных является кургасский габбро-долеритовый раннесреднерифейский комплекс. В работе собраны и обобщены данные по изотопным датировкам, петрологическим и геохимическим особенностям пород кургасского комплекса. Впервые показано наличие региональной геохимической зональности в породах комплекса, которая выражена в уменьшении содержаний SiO2 с севера на юг вдоль Башкирского мегантиклинория и увеличении содержаний MgO в этом направлении, что авторами связывается с увеличением проницаемости коры к югу при раскрытии Машакской рифтогенной структуры.Получены новые изотопные датировки для дайки, секущей саткинскую свиту нижнего рифея, – 1318±10 (40Ar/39Ar), тела в зоне экзоконтакта Бердяушского массива гранитов рапакиви – 1349±11 млн лет (U-Pb) и для дайки андезитов среди метаморфитов тараташского комплекса – 1365.6±6.6 млн лет (U-Pb). Эти данные, в сочетании с полученными ранее, указывают на формирование комплекса на достаточно большом протяжении времени – как минимум от 1385 до 1318 млн лет, что отвечает началу среднего рифея. Полученный возраст для дайки, секущей контактовую зону Бердяушского массива, позволяет предполагать, что к этому моменту массив уже в значительной мере кристаллизовался и вышел в условия хрупкой деформации

    Роль полиморфизма в промоторной области гена TNF в развитии хронической обструктивной болезни легких

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    Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars.Исследована ассоциация полиморфизма –308G/A гена фактора некроза опухолей-α (TNF) с развитием хронической обструктивной болезни легких в двух популяциях г. Томска (сибирские татары и русские). В результате, как в группах больных, так и в группах контроля, не отмечено отклонения распределений генотипов от ожидаемых при равновесии Харди—Вайнберга. Статистически значимых различий в распределении частот аллелей среди больных с ХОБЛ и в контрольных группах получено не было (p > 0,5), в том числе и между этническими группами (русские и татары). Для татар были установлены различия в распределении генотипов между больными и контрольной группой за счет преобладания гетерозитных носителей (AG) у больных (p < 0,05). Полученные данные позволяют сделать заключение о наличии ассоциации полиморфизма –308G/A гена TNF с развитием ХОБЛ у сибирских татар

    Сопряженный процесс окисления монооксида углерода и гидрокарбоксилирования циклогексена в циклогексанкарбоновую кислоту

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    The kinetic regularities of the conjugated process of the oxidation of carbon monoxide and the hydrocarboxylation of cyclohexene to cyclohexanecarboxylic acid have been studied. The copper(II) bromide addition allowed to stabilize the system and to increase selectivity due to the suppression of side reactions of the cyclohexene conversion and tetrahydrofuran. To achieve the acceptable rate and the selectivity of the transformation to cyclohexanecarboxylic acid it is advisable to use the palladium bromide concentration of 0.05 mol/L. To study the kinetic regularities the lower concentration of palladium bromide of 0.005 mol/L is required to ensure the system stability and the good reproducibility of results. The state of bromide complexes of palladium and copper under the conditions of conjugated catalytic synthesis of cyclohexanecarboxylic acid by the hydrocarboxylation of cyclohexene was studied by electron and infrared spectroscopy. It was found that during the conjugated process, copper exists in the form of copper(I) compounds, and palladium is present in the form of palladium(II) carbonyl complex. Hypotheses about the mechanism of this process were suggested. 24 two-route mechanisms of the carbon dioxide and the cyclohexanecarboxylic acid synthesis were obtained. Each of the 24 hypotheses spawned from one to three hypothetical mechanisms differing in the reversibility of the stages, the amount and the composition of intermediates accounted for in the material balance for the catalyst.Изучены кинетические закономерности сопряженного процесса окисления монооксида углерода и гидрокарбоксилирования циклогексена в циклогексанкарбоновую кислоту. Методами электрон-ной и инфракрасной спектроскопии исследовано состояние комплексов палладия и меди в системе PdBr2 - CuBr2 - ТГФ - Н2О в процессе синтеза циклогексанкарбоновой кислоты. В условиях сопряженного процесса медь существует в виде соединений Cu(I), палладий присутствует в форме карбонильного комплекса Pd(II). Выдвинуты гипотезы о механизме процесса
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