Stellar populations -- the next ten years

The study of stellar populations is a discipline that is highly dependent on both imaging and spectroscopy. I discuss techniques in different regimes of resolving power: broadband imaging (R~4), intermediate band imaging (R~16, 64), narrowband spectral imaging (R~256, 1024, 4096). In recent years, we have seen major advances in broadband all-sky surveys that are set to continue across optical and IR bands, with the added benefit of the time domain, higher sensitivity, and improved photometric accuracy. Tunable filters and integral field spectrographs are poised to make further inroads into intermediate and narrowband imaging studies of stellar populations. Further advances will come from AO-assisted imaging and imaging spectroscopy, although photometric accuracy will be challenging. Integral field spectroscopy will continue to have a major impact on future stellar population studies, extending into the near infrared once the OH suppression problem is finally resolved. A sky rendered dark will allow a host of new ideas to be explored, and old ideas to be revisited.Comment: Invited review, IAUS 241, "Stellar Populations as Building Blocks of Galaxies," eds. Vazdekis, Peletier. 12 pages, 1 table. (The sideways table should print ok; there are 10 columns.

Translating Glutamate: From Pathophysiology to Treatment

The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian brain and is responsible for most corticocortical and corticofugal neurotransmission. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders—including schizophrenia, drug abuse and addiction, autism, and depression—that were until recently poorly understood. Nevertheless, improvements in basic information regarding these disorders have yet to translate into Food and Drug Administration–approved treatments. Barriers to translation include the need not only for improved compounds but also for improved biomarkers sensitive to both structural and functional target engagement and for improved translational models. Overcoming these barriers will require unique collaborative arrangements between pharma, government, and academia. Here, we review a recent Institute of Medicine–sponsored meeting, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development.National Institute of Mental Health (U.S.) (grant R37MH49334)National Institute of Mental Health (U.S.) (Intramural Research Program)National Institute of Mental Health (U.S.) (R01DA03383)National Institute of Mental Health (U.S.) (P50MH086385)National Institutes of Health (U.S.)FRAXA Research FoundationHoward Hughes Medical InstituteSimons Foundatio

Black Cat, White Cat. The Identity of the WTO Judges

WTO judges are proposed by the WTO Secretariat and elected to act as ‘judges’ if either approved by the parties to a dispute, or by the WTO Director-General in case no agreement between the parties has been possible. They are typically ‘Geneva crowd’, that is, they are either current or former delegates representing their country before the WTO. This observation holds for both first- as well as second instance WTO judges (e.g. Panelists and members of the Appellate Body). In that, the WTO evidences an attitude strikingly similar to the GATT. Whereas the legal regime has been heavily ‘legalized’, the people called to enforce it remain the same

A Triple Test for Behavioral Economics Models and Public Health Policy

We propose a triple test to evaluate the usefulness of behavioral economics models for public health policy. Test 1 is whether the model provides reasonably new insights. Test 2 is on whether these have been properly applied to policy settings. Test 3 is whether they are corroborated by evidence. Where a test is not passed, this may point to directions for needed further research. We exemplify by considering the cases of social interactions models, self-control models and, in relation to health message framing, prospect theory; out of these, only a correctly applied prospect theory fully passes the tests at present

A Cardinal Improvement to Pseudo-Boolean Solving

Pseudo-Boolean solvers hold out the theoretical potential of exponential improvements over conflict-driven clause learning (CDCL) SAT solvers, but in practice perform very poorly if the input is given in the standard conjunctive normal form (CNF) format. We present a technique to remedy this problem by recovering cardinality constraints from CNF on the fly during search. This is done by collecting potential building blocks of cardinality constraints during propagation and combining these blocks during conflict analysis. Our implementation has a non-negligible but manageable overhead when detection is not successful, and yields significant gains for some SAT competition and crafted benchmarks for which pseudo-Boolean reasoning is stronger than CDCL. It also boosts performance for some native pseudo-Boolean formulas where this approach helps to improve learned constraints.</jats:p

Total hip replacement after nailing failure in femoral neck fractures

Forty patients were treated by means of total hip arthroplasty after nailing of femoral neck fractures had failed. Their average age was 73 years. Thirty-eight patients were still alive after 2 years and were reviewed. Two hips dislocated, but there was no early mortality. The results regarding pain, walking capacity, and function were good, and total hip replacement is considered to be the salvage operation of choice