重心系エネルギー13 TeVの陽子陽子衝突におけるヒッグス粒子のbクォークへの崩壊とベクトルボソン随伴生成を使用したヒッグス粒子の性質測定

京都大学新制・課程博士博士(理学)甲第22999号理博第4676号新制||理||1671(附属図書館)京都大学大学院理学研究科物理学・宇宙物理学専攻(主査) 長野 邦浩, 教授 中家 剛, 准教授 吉岡 興一学位規則第4条第1項該当Doctor of ScienceKyoto UniversityDFA

A wearable soft robot that can alleviate the pain and fear of the wearer

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人と人の遠隔コミュニケーションを促進する適応的で表出力のある社会的仲介ロボット

筑波大学University of Tsukuba博士（工学）Doctor of Philosophy in Engineering2021doctoral thesi

BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1

Primary cilia are antenna-like organelles that contain specific proteins, and are crucial for tissue morphogenesis. Anterograde and retrograde trafficking of ciliary proteins are mediated by the intraflagellar transport (IFT) machinery. BROMI/TBC1D32 interacts with CCRK/CDK20, which phosphorylates and activates the ICK/CILK1 kinase, to regulate the change in direction of the IFT machinery at the ciliary tip. Mutations in BROMI, CCRK, and ICK in humans cause ciliopathies, and mice defective in these genes are also known to demonstrate ciliopathy phenotypes. We here show that BROMI interacts not only with CCRK but also with CFAP20, an evolutionarily conserved ciliary protein, and with FAM149B1/JBTS36, a protein in which mutations cause Joubert syndrome. In addition, we show that FAM149B1 interacts directly with CCRK as well as with BROMI. Ciliary defects observed in CCRK-knockout (KO), BROMI-KO, and FAM149B1-KO cells, including abnormally long cilia and accumulation of the IFT machinery and ICK at the ciliary tip, resembled one another, and BROMI mutants that are defective in binding to CCRK and CFAP20 were unable to rescue the ciliary defects of BROMI-KO cells. These data indicate that CCRK, BROMI, FAM149B1, and probably CFAP20, all together regulate the IFT turnaround process under the control of ICK

人と人の遠隔コミュニケーションを促進する適応的で表出力のある社会的仲介ロボット

筑波大学University of Tsukuba博士（工学）Doctor of Philosophy in Engineering2021【要旨】thesi

Spontaneous Formation of π-Conjugated Polymeric Colloidal Molecules Through Stepwise Coacervation and Symmetric Compartmentalization

Coacervation, the phase separation of liquid induced by polymeric solutes, sometimes results in the formation of oligomeric clusters of droplets. The morphology of the clusters is non-uniform because the clustering is a consequence of the random collisions of the drifting droplets. Here we report distinctively organized coacervation, yielding colloidal molecules with monodisperse size, morphological symmetry, and compositional heterogeneity. We investigate the coacervation of a mixture of two types of synthetic polymers and find that one of the polymers coacervates first and serves as a core droplet, on which the other polymer coacervates subsequently to form satellite droplets. The satellite droplets arrange themselves symmetrically around the core and solidify without losing the morphology. The number of satellites and their symmetry are modulable depending on the chemical affinity and the diameter of the droplets. This finding highlights the capability of coacervation as a non-templated and non-covalent pathway to form aspherical colloidal materials with structural and functional complexity.</p

Highly Dispersed Ni Nanoclusters Spontaneously Formed on Hydrogen Boride Sheets

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Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation

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