Spiral wavebreak and alternating CB under IC BZ with complex geometry (right).

(A) Spiral wave break-up and alternating CB in the presence of BZ with complex geometry on the right. Colorbar indicates Vm (in the unit of mV). Snapshots of Vm at time = 0 ms, 39 ms, 75 ms and 106 ms are shown. Dashed black box indicates the place where wave break occurs. (B) Vm traces at point a.</p

Inhibition of reentry in NZ under homogeneous EpC.

(A) Suppression of reentry in the presence of homogeneous EpC at dcleft = 8 nm. Colorbar indicates Vm (in the units of mV). Snapshots of Vm at time = 0 ms, 6 ms, 25 ms and 46 ms are shown. (B) Representative Vm traces at points a (red) and b (black).</p

Inhibition of reentry under homogeneous EpC and IC BZ with complex geometry (right).

Suppression of reentry in the presence of homogeneous EpC (dcleft = 8 nm) and BZ with complex geometry to the right of the lattice. Colorbar indicates Vm (in the unit of mV). Snapshots of Vm at time = 0 ms, 7 ms, 22 ms and 92 ms are shown.</p

Inhibition of reentry under heterogeneous EpC and IC BZ with complex geometry (right).

(A) Suppression of reentry in the presence of EpC present in IC BZ and part of NZ and BZ geometry on the right of the lattice. Colorbar indicates Vm (in the unit of mV). Snapshots of Vm at time = 0 ms, 20 ms, 73 ms and 132 ms are shown. (B)Vm trace of point a.</p

Suppression of reentry in NZ under homogeneous EpC at <i>d</i>_cleft = 13 nm.

Colorbar indicates Vm (in the units of mV). Snapshots of Vm at time = 0 ms, 20 ms, 207 ms and 438 ms are shown. (PDF)</p

Spiral wavebreak and alternating CB under IC BZ with complex geometry (center).

(A) Spiral wave break-up and alternating CB in the presence of BZ with complex geometry in the center. Colorbar indicates Vm (in the unit of mV). Snapshots of Vm at time = 0 ms, 31 ms, 69 ms and 105 ms are shown. Dashed black box indicates the place where wave break occurs. (B) Vm trace of point a. (PDF)</p

Multiple spiral waves generated under gap junctional uncoupling.

(A) Multiple reentry in the presence of gap junctional uncoupling. Colorbar indicates Vm in the unit of mV. Snapshots of Vm at time = 0 ms, 600 ms, 900 ms and 1300 ms are shown. (B) Representative Vm traces at point a (red) and b (black).</p

Inhibition of reentry in a poorly coupled tissue under homogeneous EpC.

Suppression of reentry generated in poorly coupled tissue in the presence of homogeneous EpC at dcleft = 8 nm. Colorbar indicates Vm (in the unit of mV). Snapshots of Vm at time = 0 ms, 60 ms, 95 ms and 400 ms are shown.</p

Reentry generated in a poorly coupled tissue in the absence of EpC.

Reentry generated in 2D tissue of low gap junctions (1% of gap junctional coupling remains) of 550 by 550 cells in the absence of EpC. Colorbar indicates Vm (in the units of mV). Snapshots of Vm at time = 300 ms, 380 ms, 600 ms and 900 ms are shown.</p