Inclusion rates of individuals with current Pure MDD, D(m), and D(BP2) who would have met typical eligibility criteria of RCTs for MDD.

<p>Inclusion rates of individuals with current Pure MDD, D(m), and D(BP2) who would have met typical eligibility criteria of RCTs for MDD.</p

Estimated Percentages of Adults with current D(m) and Pure MDD in NESARC Seeking Treatment for depression excluded from Typical Clinical Trials of Treatments for DSM-IV MDD by Traditional Eligibility Criteria.

a<p>Derived from Zimmerman et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055448#pone.0055448-Zimmerman1" target="_blank">[29]</a> (method described in the paper).</p>b<p>Includes panic disorder, agoraphobia, social anxiety disorder, specific phobia, and generalized anxiety disorder.</p><p>Percentages are weighted values.</p><p>Abbreviations: MDD = Major Depressive Disorder, D(m) = MDD plus Subthreshold Hypomania, D(BP2) = Bipolar 2 depressive disorder, HAM-D = Hamilton Rating Scale for Depression, NESARC = National Epidemiological Survey on Alcohol and Related Conditions, NA = information not available in NESARC.</p><p>Models 1, 2, 3 and 4 indicates that subthreshold hypomania was defined as having respectively at least 1, 2, 3, or 4 lifetime concomitant hypomanic probes screening criterion A or B for hypomania.</p

Inclusion rates of individuals with current Pure MDD, D(m), and D(BP2) seeking treatment for depression who would have met typical eligibility criteria of RCTs for MDD.

<p>Inclusion rates of individuals with current Pure MDD, D(m), and D(BP2) seeking treatment for depression who would have met typical eligibility criteria of RCTs for MDD.</p

Comparisons of Exclusion Rates between Adults with current D(m), Pure MDD, and D(BP2) Seeking Treatment for depression in Typical Clinical Trials of Treatments for DSM-IV MDD by Traditional Eligibility Criteria.

a<p>Derived from Zimmerman et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055448#pone.0055448-Zimmerman1" target="_blank">[29]</a> (method described in the paper).</p>b<p>Includes panic disorder, agoraphobia, social anxiety disorder, specific phobia, and generalized anxiety disorder.</p><p>Odds ratios were estimated through logistic regression (df = 1).</p>*<p>p-value <.05; **p-value <.01; ***p-value <.001.</p><p>Abbreviations: MDD = Major Depressive Disorder, D(m) = MDD plus Subthreshold Hypomania, D(BP2) = Bipolar 2 depressive disorder, HAM-D = Hamilton Rating Scale for Depression, NESARC = National Epidemiological Survey on Alcohol and Related Conditions, NA = information not available in NESARC.</p><p>Models 1, 2, 3 and 4 indicates that subthreshold hypomania was defined as having respectively at least 1, 2, 3, or 4 lifetime concomitant hypomanic probes screening criterion A or B for hypomania.</p

Prevalence rates of individuals with current Major Depressive Disorder plus a lifetime history of Subthreshold Hypomania (D(m)) who would have met classical eligibility criteria in clinical trials for MDD.

<p>Prevalence rates of individuals with current Major Depressive Disorder plus a lifetime history of Subthreshold Hypomania (D(m)) who would have met classical eligibility criteria in clinical trials for MDD.</p

Comparisons of Exclusion Rates between Adults with current D(m), Pure MDD, and D(BP2) in Typical Clinical Trials of Treatments for DSM-IV MDD by Traditional Eligibility Criteria.

a<p>Derived from Zimmerman et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055448#pone.0055448-Zimmerman1" target="_blank">[29]</a> (method described in the paper).</p>b<p>Includes panic disorder, agoraphobia, social anxiety disorder, specific phobia, and generalized anxiety disorder.</p><p>Odds ratios were estimated through logistic regression (df = 1).</p>*<p>p-value <.05; **p-value <.01; ***p-value <.001.</p><p>Abbreviations: MDD = Major Depressive Disorder, D(m) = MDD plus Subthreshold Hypomania, D(BP2) = Bipolar 2 depressive disorder, HAM-D = Hamilton Rating Scale for Depression, NESARC = National Epidemiological Survey on Alcohol and Related Conditions, NA = information not available in NESARC.</p><p>Models 1, 2, 3 and 4 indicates that subthreshold hypomania was defined as having respectively at least 1, 2, 3, or 4 lifetime concomitant hypomanic probes screening criterion A or B for hypomania.</p

Estimated Percentages of Adults with current D(m) and Pure MDD in NESARC excluded from Typical Clinical Trials of Treatments for DSM-IV MDD by Traditional Eligibility Criteria.

a<p>Derived from Zimmerman et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055448#pone.0055448-Zimmerman1" target="_blank">[29]</a> (method described in the paper).</p>b<p>Includes panic disorder, agoraphobia, social anxiety disorder, specific phobia, and generalized anxiety disorder.</p><p>Percentages are weighted values.</p><p>Abbreviations: MDD = Major Depressive Disorder, D(m) = MDD plus Subthreshold Hypomania, D(BP2) = Bipolar 2 depressive disorder, HAM-D = Hamilton Rating Scale for Depression, NESARC = National Epidemiological Survey on Alcohol and Related Conditions, NA = information not available in NESARC.</p><p>Models 1, 2, 3 and 4 indicates that subthreshold hypomania was defined as having respectively at least 1, 2, 3, or 4 lifetime concomitant hypomanic probes screening criterion A or B for hypomania.</p

Associations between alcohol, tobacco and cannabis use and daily job exposure to the public, taking no daily exposure as reference category, in 16,566 men and 17,426 women.

<p>Associations between alcohol, tobacco and cannabis use and daily job exposure to the public, taking no daily exposure as reference category, in 16,566 men and 17,426 women.</p

Cardiovascular risk factors in participants at inclusion according to their past experience of unemployment.

Cardiovascular risk factors in participants at inclusion according to their past experience of unemployment.</p

Adjusted odds ratios (95% confidence interval) for the prevalence of cardiovascular risk factors in participants at inclusion according to their current experience of unemployment.

Adjusted odds ratios (95% confidence interval) for the prevalence of cardiovascular risk factors in participants at inclusion according to their current experience of unemployment.</p