sj-docx-1-npx-10.1177_1934578X221126299 - Supplemental material for Three New Glycosides From the Stems of <i>Derris elliptica</i>

Supplemental material, sj-docx-1-npx-10.1177_1934578X221126299 for Three New Glycosides From the Stems of Derris elliptica by Bui Thi Thu Trang, Nguyen Xuan Nhiem, Nguyen Thi Huong, Nguyen Thi Thanh Mai, Nguyen Tuan Anh and Phan Van Kiem in Natural Product Communications</p

Three new rotenoids from the stems of <i>Derris elliptica</i> and their anti-microbial activity

Three new rotenoids, named derieliptosides A-C (1–3), were isolated from the stems of Derris elliptica (Wall.) Benth. Their structures were determined by HR-ESI-MS and NMR spectroscopic methods. Absolute configurations of them were elucidated by analysis of ECD spectra in comparison with TD-DFT calculation. Compounds 1–3 inhibited the growth of fungus Candida albicans and selectively inhibited bacterial strains. Of these, compound 1 showed selective inhibition on the growth of Enterococcus faecalis (MIC: 37.5 µM and IC50: 10.6 µM), Staphylococcus aureus (MIC: 75 µM and IC50: 22.7 µM), and C. albicans (MIC: 37.5 µM and IC50: 11.2 µM).</p

sj-docx-1-npx-10.1177_1934578X221141163 - Supplemental material for New Phenylethanoid and Other Compounds From <i>Passiflora foetida</i> L., With Their Nitric Oxide Inhibitory Activities

Supplemental material, sj-docx-1-npx-10.1177_1934578X221141163 for New Phenylethanoid and Other Compounds From Passiflora foetida L., With Their Nitric Oxide Inhibitory Activities by Nguyen Van Linh, Nguyen Trung Tuong, Pham Xuan Phong and Do Thi Trang, Nguyen Xuan Nhiem, Do Hoai An, Bui Huu Tai in Natural Product Communications</p

sj-docx-1-npx-10.1177_1934578X241226825 - Supplemental material for Neolignan Glycoside and Other Constituents From the Leaves of <i>Ligustrum sinense</i> and Their Anti-Inflammatory Activity

Supplemental material, sj-docx-1-npx-10.1177_1934578X241226825 for Neolignan Glycoside and Other Constituents From the Leaves of Ligustrum sinense and Their Anti-Inflammatory Activity by Nong Thi Anh Thu, Lo Huyen Linh, Dao Anh Hoang, Nguyen Tu Oanh, Vu Mai Thao, Nguyen Thi Minh Hang and Nguyen Xuan Nhiem in Natural Product Communications</p

One new phenylpropanoid glycoside from <i>Myxopyrum smilacifolium</i> with <i>α</i>-glucosidase inhibitory activity

One new phenylpropanoid glycoside, myxosmoside I (1) and six known compounds, arenarioside (2), verbacoside (3), 3-formylindole (4), 5-hydroxymethyl furfural (5), D-manitol (6), and glycerol monooleate (7) were isolated from the roots of Myxopyrum smilacifolium (Wall.) Blume. Their chemical structures were determined by 1D-, 2D-NMR, and mass spectra, chemical methods, and compared with those reported in the literature. All compounds were evaluated for α-glucosidase inhibitory effect. Among them, phenylpropanoid glycosides 1–3 significantly inhibited α-glucosidase activity with IC50 values of 30.0 ± 0.9, 66.6 ± 2.3, and 36.9 ± 2.0 µM, respectively.</p

New 3,4<i>-seco-</i>diterpene and coumarin derivative from the leaves of <i>Trigonostemon flavidus</i> Gagnep

Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon flavidus Gagnep. by various chromatographic methods. Their chemical structures were elucidated via UV, IR, HR-ESI-MS and NMR spectroscopic methods and divided into two groups including six 3,4-seco-diterpenes (1, 3-7) and four coumarins (2, 8-10). Absolute configurations at stereocenters of compound 1 were confirmed by comparison of its CD spectra with those of the TD-DFT calculations. At a concentration of 30 µM, compounds 1–10 exhibited weak cytotoxic activity toward LU1, HepG2, MCF7, and SKMel2 human cell lines (cell viability all over 50%).</p

The chemical constituents from twigs of <i>Hamamelis japonica</i> and their antiviral activities

Three new monoterpenoid glycosides (1–3) and one new flavanol (4) along with 15 known compounds were isolated from the twig of Hamamelis japonica Sieb. et Zucc. The chemical constituent study of the twig of H. japonica has performed for the first time in the present investigation. Their structures were determined based on extensive spectroscopic methods including 1 D and 2 D NMR and CD spectra data. All isolated compounds were tested for their antiviral activities against HRV1B-, EV71-, PR8- and CVB3-infected Vero cells. Among the tested compounds, (–)-epigallocatechin 3-O-gallate exhibited the most consistent and effective antiviral activities against EV71 and PR8 infections.</p

sj-docx-1-npx-10.1177_1934578X211047705 - Supplemental material for A New <i>β</i>-Carboline Alkaloid From the Aerial Part of <i>Hedyotis capitellata</i>

Supplemental material, sj-docx-1-npx-10.1177_1934578X211047705 for A New β-Carboline Alkaloid From the Aerial Part of Hedyotis capitellata by Le Thi Huyen, Nguyen Thi Thu Hau, Hoang Son Vu, Nguyen Thi Lan Huyen, Bui Huu Tai, Nguyen Xuan Nhiem and Phan Van Kiem in Natural Product Communications</p

Isolation of amylase regulators from the leaves of <i>Ixeridium dentatum</i>

Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.</p

Achyranbidens A–C: three new compounds from <i>Achyranthes bidentata</i> Blume

Phytochemical study on the roots of Achyranthes bidentata Blume led to the isolation of sixteen compounds including three new ones (1–3). Their chemical structures were determined as oleanolic acid 28-O-β-D-glucopyranoside-3-O-[β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside) (1), methyl (8Z,11Z)-5,6,7-trihydroxytetradeca-8,11-dienoate (2), methyl (6E,11Z)-5,8,9-trihydroxytetradeca-6,11-dienoate (3), fulgidic acid (4), (9E,11E)-13-oxooctadeca-9,11-dienoic acid (5), (9Z,11E,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid (6), oleanolic acid 28-O-β-D-glucopyranoside-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucuronopyranoside (7), oleanolic acid 28-O-β-D-glucopyranoside-3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucuronopyranoside (8), oleanolic acid 3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucuronopyranoside (9), oleanolic acid 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranoside (10), blumenol C glucoside (11), citroside A (12), 6S,9S-roseoside (13), ginsenoside Rg1 (14), 20-hydroxyecdysone (15), and benzyl α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (16) by spectroscopic analysis. Compounds 1, 7 and 11–16 inhibited NO production in LPS-activated RAW264.7 cells with IC50 values in the range from 28.03 to 54.23 µM (positive control, L-NMMA: IC50 = 35.52 µM). Compounds 14 and 15 showed anti α-glucosidase activity with IC50 values of 176.24 and 156.92 µM, respectively, compared with the positive control, acarbose, IC50 = 160.99 μM.</p