Has the incidence of empyema in Scottish children continued to increase beyond 2005?

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPostprin

SUSY GUTs with Yukawa unification: a go/no-go study using FCNC processes

We address the viability of exact Yukawa unification in the context of general SUSY GUTs with universal soft-breaking sfermion and gaugino mass terms at the GUT scale. We find that this possibility is challenged, unless the squark spectrum is pushed well above the limits allowed by naturalness. This conclusion is assessed through a global fit using electroweak observables and quark flavour-changing neutral current (FCNC) processes. The problem is mostly the impossibility of accommodating simultaneously the bottom mass and the BR(B --> Xs gamma), after the stringent CDF upper bound on the decay Bs --> mu^+ mu^- is taken into account, and under the basic assumption that the b --> s gamma amplitude have like sign with respect to the Standard Model one, as indicated by the B --> Xs l^+ l^- data. With the same strategy, we also consider the possibility of relaxing Yukawa unification to b - tau Yukawa unification. We find that with small departures from the condition tan beta ~= 50, holding when Yukawa unification is exact, the mentioned tension is substantially relieved. We emphasize that in the region where fits are successful the lightest part of the SUSY spectrum is basically fixed by the requirements of b - tau unification and the applied FCNC constraints. As such, it is easily falsifiable once the LHC turns on.Comment: 10 pages, 1 figure, 5 tables. v3: A few textual modifications. Conclusions unchanged. Matches journal versio

Properdin Levels in Individuals with Chemotherapy-Induced Neutropenia

BACKGROUND: Neutrophils produce and carry key components of the alternative pathway (AP) of complement, including properdin (P). The effect of chemotherapy-induced absolute neutropenia on circulating P levels and AP function has not been previously established. METHODS: We prospectively measured free P levels in serum from 27 individuals expected to develop neutropenia after administration of chemotherapy for hematological malignancies in preparation for hematopoietic stem cell transplantation and here describe the relationship between serum P levels and the neutrophil count over time. RESULTS: When the absolute neutrophil count (ANC) was \u3e 500 cells/mm3 pre-chemotherapy, P levels were significantly higher than P levels associated with an ANC ≤500 cells/mm3 (median values 8392 ng/mL and 6355 ng/mL, respectively; P = .001). Pairwise comparison between pre-chemotherapy P levels and P levels at initial or last documented neutropenia before recovery showed a significant decline (P \u3c .0001). No correlation was observed between P levels during neutropenia and after recovery of neutropenia in 20 subjects for which postneutropenia samples were obtained. A small but significant (P = .02) decrease in AP hemolytic activity was noted between baseline (preneutropenia) and samples obtained at the onset of neutropenia, but only with low (6.25%) and not higher (12.5 or 25%) serum concentrations. CONCLUSIONS: A decline in P levels and AP activity could contribute to the increased risk of infection in neutropenic patients and warrants further study

Bone marrow recovery by morphometry during induction chemotherapy for acute lymphoblastic leukemia in children

Bone marrow architecture is grossly distorted at the diagnosis of ALL and details of the morphological changes that accompany response to Induction chemotherapy have not been reported before. While marrow aspirates are widely used to assess initial response to ALL therapy and provide some indications, we have enumerated marrow components using morphometric analysis of trephine samples with the aim of achieving a greater understanding of changes in bone marrow niches. Morphometric analyses were carried out in the bone marrow trephine samples of 44 children with ALL, using a NanoZoomer HT digital scanner. Diagnostic samples were compared to those of 32 control patients with solid tumors but without marrow involvement. Samples from patients with ALL had significantly increased fibrosis and the area occupied by bony trabeculae was lower than in controls. Cellularity was higher in ALL samples due to leukemic infiltration while the percentage of normal elements such as megakaryocytes, adipocytes, osteoblasts and osteoclasts were all significantly lower. During the course of Induction therapy, there was a decrease in the cellularity of ALL samples at day 15 of therapy with a further decrease at the end of Induction and an increase in the area occupied by adipocytes and the width of sinusoids. Reticulin fibrosis decreased throughout Induction. Megakaryocytes increased, osteoblasts and osteoclasts remained unchanged. No correlation was found between clinical presentation, early response to treatment and morphological changes. Our results provide a morphological background to further studies of bone marrow stroma in ALL

Magnetic dipole moment of the Δ+\Delta^+(1232) from the γp→γπ0p\gamma p \to \gamma \pi^0 p reaction

The $\gamma p \to \gamma \pi^0 p$ reaction in the $\Delta(1232)$-resonance region is investigated as a method to access the $\Delta^+(1232)$ magnetic dipole moment. The calculations are performed within the context of an effective Lagrangian model containing both the $\Delta$-resonant mechanism and a background of non-resonant contributions to the $\gamma p \to \gamma \pi^0 p$ reaction. Results are shown both for existing and forthcoming $\gamma p \to \gamma \pi^0 p$ experiments. In particular, the sensitivity of unpolarized cross sections and photon asymmetries to the $\Delta^+$ magnetic dipole moment is displayed for those forthcoming data.Comment: 25 pages, 11 figure

An analysis of a Heavy Gluino LSP at CDF : The Heavy Gluino Window

In this paper we consider a heavy gluino to be the lightest supersymmetric particle [LSP]. We investigate the limits on the mass of a heavy gluino LSP, using the searches for excess events in the jets plus missing momentum channel in Run I. The neutral and charged R-hadrons, containing a heavy gluino LSP, have distinct signatures at the Fermilab Tevatron. The range of excluded gluino masses depends on whether the R-hadron is charged or neutral and the amount of energy deposited in the hadronic calorimeter. The latter depends on the energy loss per collision in the calorimeter and the number of collisions; where both quantities require a model for R-hadron- Nucleon scattering. We show how the excluded range of gluino mass depends on these parameters. We find that gluinos with mass in the range between $\sim 35$ GeV and $\sim 115$ GeV are excluded by CDF Run I data. Combined with previous results of Baer et al., which use LEP data to exclude the range 3 - 22$\sim$25 GeV, our result demonstrates that an allowed window for a heavy gluino with mass between 25 and 35 GeV is quite robust. Finally we discuss the relevant differences of our analysis of Tevatron data to that of Baer et al.Comment: 36 pages, 11 figures, added an acknowledgemen

The Phenomenology of SUSY models with a Gluino LSP

In this paper we study the experimental consequences of a theory which naturally has a heavy, stable (or almost stable) gluino. We define the boundary conditions at a messenger scale $M \sim 10^{14}$ GeV which lead to this alternative phenomenologically acceptable version of the minimal supersymmetric standard model. In this theory, either the gluino or the gravitino is the lightest supersymmetric particle [LSP]. If the gravitino is the LSP, then the gluino is the next-to-LSP with a lifetime on the order of 100 years. In either case, the gluino is (for all practical purposes) a stable particle with respect to experiments at high energy accelerators. Thus the standard missing energy signature for SUSY fails. A stable gluino forms a color singlet hadron, the lightest of which is assumed to be an isoscalar gluino-gluon bound state ($R_0$). The $R_0$ has strong interactions and will interact in a hadronic calorimeter; depositing some fraction of its kinetic energy. Finally, in the case the gravitino is the LSP, bounds from searches for stable heavy isotopes of hydrogen or oxygen do not apply to the metastable $R_0$.Comment: 34 pages, 16 figures color code

Study of Constrained Minimal Supersymmetry

Taking seriously phenomenological indications for supersymmetry, we have made a detailed study of unified minimal SUSY, including effects at the few percent level in a consistent fashion. We report here a general analysis without choosing a particular unification gauge group. We find that the encouraging SUSY unification results of recent years do survive the challenge of a more complete and accurate analysis. Taking into account effects at the 5-10% level leads to several improvements of previous results, and allows us to sharpen our predictions for SUSY in the light of unification. We perform a thorough study of the parameter space. The results form a well-defined basis for comparing the physics potential of different facilities. Very little of the acceptable parameter space has been excluded by LEP or FNAL so far, but a significant fraction can be covered when these accelerators are upgraded. A number of initial applications to the understanding of the SUSY spectrum, detectability of SUSY at LEP II or FNAL, BR($b\to s\gamma$), Width($Z\to b\bar b$), dark matter, etc, are included in a separate section. We formulate an approach to extracting SUSY parameters from data when superpartners are detected. For small tan(beta) or large $m_top$ both $M_half$ and $M_0$ are entirely bounded from above at O(1 tev) without having to use a fine-tuning constraint.Comment: Michigan preprint UM-TH-93-24, LaTeX, 60 pages without figures. Complete paper with inline figures available by anonymous ftp to williams.physics.lsa.umich.edu in /pub/preprints/UM-TH-93-24.ps.Z (uncompresses to 10MB / 77 pages), or by e-mailing reques

Are Nanoparticles Spherical or Quasi-Spherical?

The geometry of quasi-spherical nanoparticles is investigated. The combination of SEM imaging and electrochemical nano-impact experiments is demonstrated to allow sizing and characterization of the geometry of single silver nanoparticles

Nonrandom processes maintain diversity in tropical forests

An ecological community\u27s species diversity tends to erode through time as a result of stochastic extinction, competitive exclusion, and unstable host-enemy dynamics. This erosion of diversity can be prevented over the short term if recruits are highly diverse as a result of preferential recruitment of rare species or, alternatively, if rare species survive preferentially, which increases diversity as the ages of the individuals increase. Here, we present census data from seven New and Old World tropical forest dynamics plots that all show the latter pattern. Within local areas, the trees that survived were as a group more diverse than those that were recruited or those that died. The larger (and therefore on average older) survivors were more diverse within local areas than the smaller survivors. When species were rare in a local area, they had a higher survival rate than when they were common, resulting in enrichment for rare species and increasing diversity with age and size class in these complex ecosystems