Pattern formation in a diffusion-ODE model with hysteresis

Coupling diffusion process of signaling molecules with nonlinear interactions of intracellular processes and cellular growth/transformation leads to a system of reaction-diffusion equations coupled with ordinary differential equations (diffusion-ODE models), which differ from the usual reaction-diffusion systems. One of the mechanisms of pattern formation in such systems is based on the existence of multiple steady states and hysteresis in the ODE subsystem. Diffusion tries to average different states and is the cause of spatio-temporal patterns. In this paper we provide a systematic description of stationary solutions of such systems, having the form of transition or boundary layers. The solutions are discontinuous in the case of non-diffusing variables whose quasi-stationary dynamics exhibit hysteresis. The considered model is motivated by biological applications and elucidates a possible mechanism of formation of patterns with sharp transitions.Comment: 32 pages, 8 picture

Magnetic record support

The magnetic layer of a magnetic record support is coated with a thin film of a polymer with a siloxane bond. The magnetic layer consists of a thin film obtained by vacuum metallization, cathode sputtering or dispersion of a ferromagnetic metal powder in a binder. The polymer with a siloxane bond is produced by the polymerization of an organic silicon compound which inherently contains or is able to form this bond. Polymerization is preferably performed by plasma polymerization

Pressure-induced phase transition of Bi2Te3 into the bcc structure

The pressure-induced phase transition of bismuth telluride, Bi2Te3, has been studied by synchrotron x-ray diffraction measurements at room temperature using a diamond-anvil cell (DAC) with loading pressures up to 29.8 GPa. We found a high-pressure body-centered cubic (bcc) phase in Bi2Te3 at 25.2 GPa, which is denoted as phase IV, and this phase apperars above 14.5 GPa. Upon releasing the pressure from 29.8 GPa, the diffraction pattern changes with pressure hysteresis. The original rhombohedral phase is recovered at 2.43 GPa. The bcc structure can explain the phase IV peaks. We assumed that the structural model of phase IV is analogous to a substitutional binary alloy; the Bi and Te atoms are distributed in the bcc-lattice sites with space group Im-3m. The results of Rietveld analysis based on this model agree well with both the experimental data and calculated results. Therefore, the structure of phase IV in Bi2Te3 can be explained by a solid solution with a bcc lattice in the Bi-Te (60 atomic% tellurium) binary system.Comment: 12 pages, 5 figure

Regulation of Epidermal Growth Factor Receptor Expression and Morphology of Lung Epithelial Cells by Interleukin-1β

学位論文博士（医学）http://purl.org/coar/resource_type/c_db06琉球大

Complex polarity: building multicellular tissues through apical membrane traffic

The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level

Development of lessons on Handball Focusing on "the motions of players without balls": Through Lesson Practice in Third Grade Elementary School

本研究は，小学校第3学年におけるボール非保持者の「ボールを持たないときの動き」に着目したハンドボールの授業づくりの有効性とその課題について考察することをねらいとする。授業実践では，3対1や3対2のアウトナンバーをつくり，攻守交代制のゲームを行った。また，コート内にグリッドをつくり，守備の動ける範囲を制限するとともに，攻撃は2つのグリッドに必ずパスを入れることを条件とした。その結果，攻守交代制のゲームは，攻守ともにゴールの方向が明瞭になることから，ねらった動きを表出する一つの要因であることが示唆された。さらに，アウトナンバーでのゲームは，ボール非保持者が，グリッド内で守備からはなれた空間，すなわちパスをもらったりシュートを打ったりするための有効な空間を見つけることに有効であったと考えられる。This study aims to examine effectiveness and problems in developing classes of handball focusing on "the motions of players without ball" in third grade in elementary school. In practice of lessons, the researcher set an outnumbered situation such as three-to-one or three-to-two and allowed students to play games taking turn in offense and defense. In addition, the researcher provided two conditions: 1) the area where defense can move around is limited 2) the offense always passes the ball to two grid areas. The results suggest that in the games turning offense and defense, players without ball managed to move on their purpose since the directions of goals became clear. Moreover, the results reveal that the outnumbered games were effective for players without ball to find the space far from their defense in the grid areas where they could pass and shoot ball

The trispectrum in ghost inflation

We calculate the trispectrum in ghost inflation where both the contact diagram and scale-exchange diagram are taken into account. The shape of trispectrum is discussed carefully and we find that the local form is absent in ghost inflation. In general, for the non-local shape trispectrum there are not analogous parameters to $\tau_{NL}^{loc.}$ and $g_{NL}^{loc.}$ which can completely characterize the size of local form trispectrum.Comment: 19 pages, 8 figures; clarifications and corrections added, version accepted for publication in JCA

Characterization of Elementary School Districts – A model study in Himeji City –

　この研究では，小学校の通学区域を国勢調査結果や住民基本台帳データのうち小学校の通 学区域（学区）別に編纂されているものを用いてそれらの類型化を試み，その結果を地図上 に表現した。そのような類型が生じる背景にある人口学的な性質を考察し，学校ごとに濃淡 がある児童生徒の種々の健康課題について，日常生活における背景を考察するためのツール としての可能性に言及した

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites

The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the chromatin structure and DNA repair process. Whether p300/CBP at DSB sites also acetylate non-histone proteins, and how their acetylation affects DSB repair, remain unknown. Here we show that p300/CBP acetylate RAD52, a human homologous recombination (HR) DNA repair protein, at DSB sites. Using in vitro acetylated RAD52, we identified 13 potential acetylation sites in RAD52 by a mass spectrometry analysis. An immunofluorescence microscopy analysis revealed that RAD52 acetylation at DSBs sites is counteracted by SIRT2- and SIRT3-mediated deacetylation, and that non-acetylated RAD52 initially accumulates at DSB sites, but dissociates prematurely from them. In the absence of RAD52 acetylation, RAD51, which plays a central role in HR, also dissociates prematurely from DSB sites, and hence HR is impaired. Furthermore, inhibition of ataxia telangiectasia mutated (ATM) protein by siRNA or inhibitor treatment demonstrated that the acetylation of RAD52 at DSB sites is dependent on the ATM protein kinase activity, through the formation of RAD52, p300/CBP, SIRT2, and SIRT3 foci at DSB sites. Our findings clarify the importance of RAD52 acetylation in HR and its underlying mechanism