Preparation of MIL-53(Fe)-Reduced Graphene Oxide Nanocomposites by a Simple Self-Assembly Strategy for Increasing Interfacial Contact: Efficient Visible-Light Photocatalysts

In this work, MIL-53­(Fe)-reduced graphene oxide (M53-RGO) nanocomposites have been successfully fabricated by a facile and efficient electrostatic self-assembly strategy for improving the interfacial contact between RGO and the MIL-53­(Fe). Compared with D-M53-RGO (direct synthesis of MIL-53­(Fe)-reduced graphene oxide nanocomposites via one-pot solvothermal approach), M53-RGO nanocomposites exhibit improved photocatalytic activity compared with the D-M53-RGO under identical experimental conditions. After 80 min of visible light illumination (λ ≥ 420 nm), the reduction ratio of Cr­(VI) is rapidly increased to 100%, which is also higher than that of reference sample (N-doped TiO₂). More significantly, the M53-RGO nanocomposites are proven to perform as bifunctional photocatalysts with considerable activity in the mixed systems (Cr­(VI)/dyes) under visible light, which made it a potential candidate for industrial wastewater treatment. Combining with photoelectrochemical analyses, it could be revealed that the introduction of RGO would minimize the recombination of photogenerated electron–hole pairs. Additionally, the effective interfacial contact between MIL-53­(Fe) and RGO surface would further accelerate the transfer of photogenerated electrons, leading to the enhancement of photocatalytic activity of M53-RGO toward photocatalytic reactions. Finally, a possible photocatalytic reaction mechanism is also investigated in detail

Table1_Dl-3-n-butylphthalide attenuates cerebral ischemia/reperfusion injury in mice through AMPK-mediated mitochondrial fusion.DOCX

Introduction: NBP is a compound isolated from celery seeds, which was approved by the National Medical Products Administration in 2002 for clinical treatment of ischemic stroke. However, in brain ischemia/reperfusion (I/R) injury, the related research on mitochondrial dynamics and its mechanism of action of NBP still need to be further studied. The aim of this study was to assess NBP on cerebral pathology in ischemic stroke in vivo, with a specific focus on the molecular mechanisms of how NBP promotes mitochondrial fusion.Methods: Male C57BL/6 mice were utilized in this study and were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Pre-ischemia, NBP was administered through intraperitoneal (i.p.) injection for 7 days.Results: Our findings demonstrated that NBP effectively reduced infarct volume, improved neurological dysfunction, enhanced cerebral blood flow, and promoted mitochondrial fusion in mice subjected to MCAO/R. More importantly, the pro-fusion effects of NBP were found to be linked to the activation of AMPK/Mfn1 pathway, and with the activation of neurological function, which was partially eliminated by inhibitors of AMPK.Discussion: Our results revealed that NBP is a novel mitochondrial fusion promoter in protecting against ischemic stroke through the AMPK-mediated Mfn1. These findings contribute to the understanding of novel mechanisms involved in the protection of neurological function following NBP treatment for ischemic stroke.</p

Additional file 4: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Table S3. The candidate P. falciparum genes probably responsible for parasitizing human erythrocytes. (XLSX 16 kb

Additional file 5: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Table S4. The P. berghei genes included in rodent malaria parasite-enriched clusters. (XLSX 20 kb

Additional file 1: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Table S1. The corresponding relationships between 33,314 genes and 4605 clusters. (XLSX 605 kb

Additional file 8: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Figure S4. Expression dynamics of SURF family members in the intraerythrocytic cycle of the P. falciparum parasite. (TIF 75 kb

Additional file 9: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Table S5. Candidate genes related to virulence of the P. falciparum parasite. (XLSX 31 kb

Additional file 6: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Figure S2. Genomic location of 115 P. falciparum genes. (TIF 968 kb

One-Dimensional CdS/TiO₂ Nanofiber Composites as Efficient Visible-Light-Driven Photocatalysts for Selective Organic Transformation: Synthesis, Characterization, and Performance

CdS/TiO₂ heterojunction nanofibers have been successfully synthesized through the photodeposition of CdS on 1D TiO₂ nanofibers that were prepared via a facile electrospinning method. The as-synthesized samples showed high photocatalytic activities upon selectively oxidizing a series of alcohols into corresponding aldehydes under visible light irradiation. TEM observations revealed that CdS was closely grown on the TiO₂ nanofibers. Moreover, it was found that the CdS/TiO₂ nanofibers that were photodeposited for 4 h exhibited the highest catalytic activity, with a conversion of 22% and a selectivity of 99%, which were much higher than those of commercial CdS. In addition, we also discuss the photoabsorption performance and the reaction mechanism of the photocatalytic oxidation of alcohols

Additional file 2: of In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Figure S1. Clusters composed of members from a single species or six species. a) Clusters comprise P. vavix genes (left panel) or P. falciparum genes (right panel). b) Clusters comprising genes from six Plasmodium species. (TIF 1617 kb