158 research outputs found

    Resolved Depletion Zones and Spatial Differentiation of N2H+ and N2D+

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    We present a study on the spatial distribution of N2D+ and N2H+ in thirteen protostellar systems. Eight of thirteen objects observed with the IRAM 30m telescope show relative offsets between the peak N2D+ (J=2-1) and N2H+ (J=1-0) emission. We highlight the case of L1157 using interferometric observations from the Submillimeter Array and Plateau de Bure Interferometer of the N2D+ (J=3-2) and N2H+ (J=1-0) transitions respectively. Depletion of N2D+ in L1157 is clearly observed inside a radius of ~2000 AU (7") and the N2H+ emission is resolved into two peaks at radii of ~1000 AU (3.5"), inside the depletion region of N2D+. Chemical models predict a depletion zone in N2H+ and N2D+ due to destruction of H2D+ at T ~ 20 K and the evaporation of CO off dust grains at the same temperature. However, the abundance offsets of 1000 AU between the two species are not reproduced by chemical models, including a model that follows the infall of the protostellar envelope. The average abundance ratios of N2D+ to N2H+ have been shown to decrease as protostars evolve by Emprechtinger et al., but this is the first time depletion zones of N2D+ have been spatially resolved. We suggest that the difference in depletion zone radii for N2H+ and N2D+ is caused by either the CO evaporation temperature being above 20 K or an H2 ortho-to-para ratio gradient in the inner envelope.Comment: Accepted to ApJ. 44 pages 13 Figure

    A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients.

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    BACKGROUND: We sought to assess physician interest in molecular prognosic testing for patients with early stage colon cancer, and identify factors associated with the likelihood of test adoption. METHODS: We identified physicians who care for patients with early-stage (pN0) colon cancer patients, mailed them a survey, and analyzed survey responses to assess clinician receptivity to the use of a new molecular test (GUCY2C) that identifies patients at risk for recurrence, and clinician readiness to act on abnormal test results. RESULTS: Of 104 eligible potential respondents, 41 completed and returned the survey. Among responding physicians, 56 % were receptive to using the new prognostic test. Multivariable analyses showed that physicians in academic medical centers were significantly more receptive to molecular test use than those in non-academic settings. Forty-one percent of respondents were ready to act on abnormal molecular test results. Physicians who viewed current staging methods as inaccurate and were confident in their capacity to incorporate molecular testing in practice were more likely to say they would act on abnormal test results. CONCLUSIONS: Physician receptivity to molecular diagnostic testing for early-stage colon cancer patients is likely to be influenced by practice setting and perceptions related to delivering quality care to patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01972737

    Social Activism in IS Research: Making the World a Better Place

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    Information Systems (IS) can play a salient role in the transformation of our societies, especially in less-developed (or under-served) communities. IS can be used to benefit citizens in these societies through improvements in education, government, healthcare, social, and entrepreneurial systems. It would be a mistake to think that under-served communities can develop without optimal deployment of IS, after all advanced societies depended on IS to boost their development. The realization that IS offers potential benefit to improve the livelihood of the less-privileged is not new or recent. However, what is not clear is what should be the role of IS researchers in addressing the needs of the under-served communities

    Social Activism in Information Systems Research: Making the World a Better Place

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    This paper reports on a panel held during the 2006 International Conference on Information Systems (ICIS). The panel titled, Social Activism in IS Research: Making the World a Better Place, was organized to question whether and how Information System (IS) research is making tangible impacts to our society. More specifically, each panelist was asked to address: (1) How can IS research, and researchers, make contributions to underdeveloped societies and underserved communities?; and (2) How can IS researchers learn from the particularities of these communities to inform better research, teaching, and service? While each panel member had different perspectives to offer in relation to these two questions, all agreed that IS academe needs to raise its awareness and efforts considerably with a view to address the needs of underserved communities

    Higher Derivative Corrections to R-charged Black Holes: Boundary Counterterms and the Mass-Charge Relation

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    We carry out the holographic renormalization of Einstein-Maxwell theory with curvature-squared corrections. In particular, we demonstrate how to construct the generalized Gibbons-Hawking surface term needed to ensure a perturbatively well-defined variational principle. This treatment ensures the absence of ghost degrees of freedom at the linearized perturbative order in the higher-derivative corrections. We use the holographically renormalized action to study the thermodynamics of R-charged black holes with higher derivatives and to investigate their mass to charge ratio in the extremal limit. In five dimensions, there seems to be a connection between the sign of the higher derivative couplings required to satisfy the weak gravity conjecture and that violating the shear viscosity to entropy bound. This is in turn related to possible constraints on the central charges of the dual CFT, in particular to the sign of c-a.Comment: 30 pages. v2: references added, some equations simplifie

    Generating Temperature Flow for eta/s with Higher Derivatives: From Lifshitz to AdS

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    We consider charged dilatonic black branes in AdS_5 and examine the effects of perturbative higher derivative corrections on the ratio of shear viscosity to entropy density eta/s of the dual plasma. The structure of eta/s is controlled by the relative hierarchy between the two scales in the plasma, the temperature and the chemical potential. In this model the background near-horizon geometry interpolates between a Lifshitz-like brane at low temperature, and an AdS brane at high temperatures -- with AdS asymptotics in both cases. As a result, in this construction the viscosity to entropy ratio flows as a function of temperature, from a value in the IR which is sensitive to the dynamical exponent z, to the simple result expected for an AdS brane in the UV. Coupling the scalar directly to the higher derivative terms generates additional temperature dependence, and leads to a particularly interesting structure for eta/s in the IR.Comment: Plots and references added. Journal version of the pape

    On the Temperature Dependence of the Shear Viscosity and Holography

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    We examine the structure of the shear viscosity to entropy density ratio eta/s in holographic theories of gravity coupled to a scalar field, in the presence of higher derivative corrections. Thanks to a non-trivial scalar field profile, eta/s in this setup generically runs as a function of temperature. In particular, its temperature behavior is dictated by the shape of the scalar potential and of the scalar couplings to the higher derivative terms. We consider a number of dilatonic setups, but focus mostly on phenomenological models that are QCD-like. We determine the geometric conditions needed to identify local and global minima for eta/s as a function of temperature, which translate to restrictions on the signs and ranges of the higher derivative couplings. Finally, such restrictions lead to an holographic argument for the existence of a global minimum for eta/s in these models, at or above the deconfinement transition.Comment: references adde

    'To live and die [for] Dixie': Irish civilians and the Confederate States of America

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    Around 20,000 Irishmen served in the Confederate army in the Civil War. As a result, they left behind, in various Southern towns and cities, large numbers of friends, family, and community leaders. As with native-born Confederates, Irish civilian support was crucial to Irish participation in the Confederate military effort. Also, Irish civilians served in various supporting roles: in factories and hospitals, on railroads and diplomatic missions, and as boosters for the cause. They also, however, suffered in bombardments, sieges, and the blockade. Usually poorer than their native neighbours, they could not afford to become 'refugees' and move away from the centres of conflict. This essay, based on research from manuscript collections, contemporary newspapers, British Consular records, and Federal military records, will examine the role of Irish civilians in the Confederacy, and assess the role this activity had on their integration into Southern communities. It will also look at Irish civilians in the defeat of the Confederacy, particularly when they came under Union occupation. Initial research shows that Irish civilians were not as upset as other whites in the South about Union victory. They welcomed a return to normalcy, and often 'collaborated' with Union authorities. Also, Irish desertion rates in the Confederate army were particularly high, and I will attempt to gauge whether Irish civilians played a role in this. All of the research in this paper will thus be put in the context of the Drew Gilpin Faust/Gary Gallagher debate on the influence of the Confederate homefront on military performance. By studying the Irish civilian experience one can assess how strong the Confederate national experiment was. Was it a nation without a nationalism
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