2 research outputs found

    Endothelial dysfunction in cardiometabolic health

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    Introducci贸n: las enfermedades cardiometab贸licas son de las principales causas de muerte de personas en todo el mundo y disfunci贸n endotelial interrumpe la permeabilidad de la barrera endotelial que forma parte de la respuesta inflamatoria en el desarrollo de estas. Como tal, la anulaci贸n de la activaci贸n e inflamaci贸n de las c茅lulas endoteliales tiene relevancia cl铆nica, promoviendo este grupo de enfermedades degenerativas.  Objetivo: exponer las generalidades del endotelio y la asociaci贸n de su disfunci贸n con algunas de las principales enfermedades cardiometab贸licas abordadas en el primer nivel de atenci贸n. Metodolog铆a: revisi贸n narrativa de la literatura que incluy贸 52 art铆culos seleccionados en base a su disponibilidad abierta y ser publicados en ingl茅s y espa帽ol. Conclusiones: el endotelio, como c茅lula activa en el proceso de inflamaci贸n 鈥 incluida la inflamaci贸n silente o de bajo grado 鈥 constituye una diana de profundo estudio por parte de los profesionales de la salud que trabajan con pacientes cardio metab贸licos, el enfoque dirigido a esta y a sus productos por y antiinflamatorios, en un futuro no lejano, podr铆a incrementar a煤n m谩s en el contexto del tratamiento m茅dico y la prevenci贸n cardiometab贸lica.Introduction: cardiometabolic diseases are one of the main causes of death of people worldwide and endothelial dysfunction interrupts the permeability of the endothelial barrier that is part of the inflammatory response in their development. As such, suppression of endothelial cell activation and inflammation has clinical relevance, promoting this group of degenerative diseases. Objective: to expose the generalities of the endothelium and the association of its dysfunction with some of the main cardiometabolic diseases addressed in the first level of care. Methodology: narrative review of the literature that included fifty-two articles selected based on their open availability and being published in English and Spanish. Conclusion: the endothelium, as an active cell in the inflammation process - including silent or low-grade inflammation - constitutes a target of in-depth study by health professionals who work with cardiometabolic patients, the approach directed at it and its Pro and anti-inflammatory products, in the not-too-distant future, could increase even more in the context of medical treatment and cardiometabolic prevention

    Transcriptomic profiles and diagnostic biomarkers in the Mediterranean seagrasses Posidonia oceanica and Cymodocea nodosa reveal mechanistic insights of adaptative strategies upon desalination brine stress

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    Seawater desalination by reverse osmosis is growing exponentially due to water scarcity. Byproducts of this process (e.g. brines), are generally discharged directly into the coastal ecosystem, causing detrimental effects, on benthic organisms. Understanding the cellular stress response of these organisms (biomarkers), could be crucial for establishing appropriate salinity thresholds for discharged brines. Early stress biomarkers can serve as valuable tools for monitoring the health status of brine-impacted organisms, enabling the prediction of long-term irreversible damage caused by the desalination industry. In this study, we conducted laboratory-controlled experiments to assess cellular and molecular biomarkers against brine exposure in two salinity-sensitive Mediterranean seagrasses: Posidonia oceanica and Cymodocea nodosa. Treatments involved exposure to 39, 41, and 43 psu, for 6 h and 7 days. Results indicated that photosynthetic performance remained unaffected across all treatments. However, under 43 psu, P. oceanica and C. nodosa exhibited lipid oxidative damage, which occurred earlier in P. oceanica. Additionally, P. oceanica displayed an antioxidant response at higher salinities by accumulating phenolic compounds within 6 h and ascorbate within 7 d; whereas for C. nodosa the predominant antioxidant mechanisms were phenolic compounds accumulation and total radical scavenging activity, which was evident after 7 d of brines exposure. Finally, transcriptomic analyses in P. oceanica exposed to 43 psu for 7 days revealed a poor up-regulation of genes associated with brassinosteroid response and abiotic stress response, while a high down-regulation of genes related to primary metabolism was detected. In C. nodosa, up-regulated genes were involved in DNA repair, cell cycle regulation, and reproduction, while down-regulated genes were mainly associated with photosynthesis and ribosome assembly. Overall, these findings suggest that 43 psu is a critical salinity-damage threshold for both seagrasses; and despite the moderate overexpression of several transcripts that could confer salt tolerance, genes involved in essential biological processes were severely downregulated.FRR was financed by Fondecyt #11220425 grant from ANID, Chile. CAS was financed by project ANID InES I + D 2021 (INID210013) and by Marie Sk艂odowska-Curie Action (888415). FBM was supported by a grant from Universidad de Alicante (Grant ID: FPUUA98)
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