8,699 research outputs found

    Epigenomes in Cardiovascular Disease.

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    If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies

    Magnetic ordering and fluctuation in kagome lattice antiferromagnets, Fe and Cr jarosites

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    Jarosite family compounds, KFe_3(OH)_6(SO_4)_2, (abbreviate Fe jarosite), and KCr_3(OH)_6(SO_4)_2, (Cr jarosite), are typical examples of the Heisenberg antiferromagnet on the kagome lattice and have been investigated by means of magnetization and NMR experiments. The susceptibility of Cr jarosite deviates from Curie-Weiss law due to the short-range spin correlation below about 150 K and shows the magnetic transition at 4.2 K, while Fe jarosite has the transition at 65 K. The susceptibility data fit well with the calculated one on the high temperature expansion for the Heisenberg antiferromagnet on the kagome lattice. The values of exchange interaction of Cr jarosite and Fe jarosite are derived to be J_Cr = 4.9 K and J_Fe = 23 K, respectively. The 1H-NMR spectra of Fe jarosite suggest that the ordered spin structure is the q = 0 type with positive chirality of the 120 degrees configuration. The transition is caused by a weak single-ion type anisotropy. The spin-lattice relaxation rate, 1/T_1, of Fe jarosite in the ordered phase decreases sharply with lowering the temperature and can be well explained by the two-magnon process of spin wave with the anisotropy.Comment: REVTeX, 14 pages with 5 figures. Submitted to Canadian Journal of Physic

    Effect of the atmosphere on the classification of LANDSAT data

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    The author has identified the following significant results. In conjunction with Turner's model for the correction of satellite data for atmospheric interference, the LOWTRAN-3 computer was used to calculate the atmospheric interference. Use of the program improved the contrast between different natural targets in the MSS LANDSAT data of Brasilia, Brazil. The classification accuracy of sugar canes was improved by about 9% in the multispectral data of Ribeirao Preto, Sao Paulo

    Study of the atmospheric effects on the radiation detected by the sensor aboard orbiting platforms (ERTS/LANDSAT)

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    The author has identified the following significant results. Multispectral scanner data for Brasilia was corrected for atmospheric interference using the LOWTRAN-3 computer program and the analytical solution of the radiative transfer equation. This improved the contrast between two natural targets and the corrected images of two different dates were more similar than the original ones. Corrected images of MSS data for Ribeirao Preto gave a classification accuracy for sugar cane about 10% higher as compared to the original images

    Cyclotron radiation and emission in graphene

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    Peculiarity in the cyclotron radiation and emission in graphene is theoretically examined in terms of the optical conductivity and relaxation rates to propose that graphene in magnetic fields can be a candidate to realize the Landau level laser, proposed decades ago [H. Aoki, Appl. Phys. Lett. {\bf 48}, 559 (1986)].Comment: 4 pages, 3 figure

    Bending and springback prediction method based on multi-scale finite element analyses for high bendability and low springback sheet generation

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    In this study, a sheet bendability and springback property evaluation technology through bending test simulations is newly developed using our multi-scale finite element analysis code, which is based on the crystallographic homogenization method

    Depositional constraints and age of metamorphism in southern India: U-Pb chemical (EMPA) and isotopic (SIMS) ages from the Trivandrum Block

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    We report U–Pb electron microprobe (zircon and monazite) and Secondary Ion Mass Spectrometry (SIMS) U–Pb (zircon) ages from a granulite-facies metapelite and a garnet–biotite gniess from Chittikara, a classic locality within the Trivandrum Block of southern India. The majority of the electron-microprobe data on zircons from the metapelite define apparent ages between 1500 and 2500 Ma with a prominent peak at 2109±22 Ma, although some of the cores are as old as 3070 Ma. Zircon grains with multiple age zoning are also detected with 2500–3700 Ma cores, 1380–1520 mantles and 530–600 Ma outer rims. Some homogeneous and rounded zircon cores yielded late Neoproterozoic ages that suggest that deposition within the Trivandrum Block belt was younger than 610 Ma. The outermost rims of these grains are characterized by early Cambrian ages suggesting metamorphic overgrowth at this time. The apparent ages of monazite grains from this locality reveal multiple provenance and polyphase metamorphic history, similar to those of the zircons. In a typical case, Palaeoproterozoic cores (1759–1967 Ma) are enveloped by late Neoproterozoic rims (562–563 Ma), which in turn are mantled by an outermost thin Cambrian rim ([similar]515 Ma). PbO v. ThO*2 plots for monazites define broad isochrons, with cores indicating a rather imprecise age of 1913±260 Ma (MSWD=0.80) and late Neoproterozoic/Cambrian cores as well as thin rims yielding a well-defined isochron with an age of 557±19 Ma (MSWD=0.82). SIMS U–Pb isotopic data on zircons from the garnet–biotite gneiss yield a combined core/rim imprecise discordia line between 2106±37 Ma and 524±150 Ma. The data indicate Palaeoproterozoic zircon formation with later partial or non-uniform Pb loss during the late Neoproterozoic/Cambrian tectonothermal event. The combined electron probe and SIMS data from the metapelite and garnet–biotite gneiss at Chittikara indicate that the older zircons preserved in the finer-grained metapelite protolith have heterogeneous detrital sources, whereas the more arenaceous protolith of the garnet–biotite gniess was sourced from a single-aged terrane. Our data suggest that the metasedimentary belts in southern India may have formed part of an extensive late Neoproterozoic sedimentary basin during the final amalgamation of the Gondwana supercontinent.M. Santosh, A. S. Collins, T. Morimoto and K. Yokoyam
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