Renal Sympathetic Denervation and Quality of Life

ABSTRACTBackgroundRenal sympathetic denervation (RSD) is a promising strategy in the treatment of resistant hypertension. No studies have assessed the effect of RSD on quality of life in our country, which was the aim of this study.MethodsThe EuroQol5 Dimensions questionnaire (EQ5D5L) was chosen to evaluate quality of life in 10 patients undergoing RSD, and it was applied before and 3 months after the procedure.ResultsMean age was 47.3 ± 12 years and 90% of the patients were female. Baseline blood pressure was 187 ± 37.5/104 ± 18.5mmHg and the number of antihypertensive drugs was 7.6 ± 1.3. Before the procedure, the value assigned to health status was 37.5 ± 22.7, increasing at 3 months to 70.5 ± 20.9 (P = 0.01). In the follow-up, in addition to a decrease in the number of antihypertensive drugs (7.6 ± 1.3 vs. 6 ± 2.2; P = 0.05), a trend towards reduced levels of systolic blood pressure (187 ± 36mmHg vs 170 ± 44mmHg; P = 0.10) and diastolic blood pressure (104 ± 18mmHg vs 98 ± 20mmHg; P = 0.20) was observed. Health status improvement resulted from a reduction of problems related to mobility, usual activities, pain/discomfort and anxiety/depression. The magnitude of blood pressure reduction was not associated with improved quality in all of the patients. On the other hand, those who had a decrease in the number of antihypertensive drugs reported a better health status.ConclusionsPatients with resistant hypertension have poor health status scores. RSD improved quality of life in most patients. Further studies are required to confirm consistent benefits

Isolamento, caracterização biológica e molecular de acanthamoeba: determinação do potencial patogênico no Distrito Federal

O gênero Acanthamoeba pertence a um grupo de protozoários anfizóicos que podem ou não ser patogênicos. A patogenicidade é determinada por parâmetros morfológicos, físicos, bioquímicos e moleculares. Fatores como osmotolerância e a termotolerância contribuem para a determinação da patogenicidade. A técnica de Reação em Cadeia da Polimerase (PCR) vem apresentando resultados mais promissores para a identificação do gênero. O objetivo deste trabalho foi isolar amebas de vida livre do gênero Acanthamoeba em piscinas públicas do DF e espelhos-d’água localizados no Eixo Monumental, Brasília-DF, bem como determinar o potencial patogênico dos isolados. Foi observado crescimento de AVLs em todas as amostras. O gênero Acanthamoeba foi encontrado em 20 amostras pela cultura e confirmados pela PCR. Desses, 14 apresentaram algum grau de patogenicidade nos testes de osmotolerancia e termotolerância

Intelligent Automation System in Asset Safety Using Household

This article describes the main stages of a project used in Home Automation (Home Automation), highlighting many general aspects about advantages and disadvantages of investing in this automation, costs and availability. The forms, propositions and compositions are also exposed for a Home Automation System to work in a pleasant way that can meet the needs and demand of a demanding emerging market. The illustrations in the course of the article proved to be not so simple to program. There is a need to find qualified professionals in the area of home automation for the complete fluidity of the project. A complete model is proposed where the main difficulties are highlighted and resolved

Carvão ativado no estabelecimento in vitro de cultivares de framboeseira

Propagation of raspberry (Rubus idaeus L.) is usually performed from root cuttings. Although fruits have viable seeds, sexual reproduction is unwanted due to the high genetic variability and long juvenile period besides dormancy, which causes plant development to be slow and consequently produces the same result in the production of new seedlings. So, in vitro micropropagation is a viable technique for seedling production, thus maintaining genetic features of the mother plant, uniformity, precocity of production, as well as accelerating the conventional propagation methods, are an alternative to planters. The aim was the evaluation of the effect of different concentration ratios of activated charcoal supplied in the growth medium on the different raspberry cultivars. Activated charcoal was used (0; 2; and 4 g L-1), and the raspberry cultivars were (Indian Summer, Heritage, Willamette, Golden Bliss, Polana, Fallgold, Schönemann, and Bababerry). The best oxidation control was presented on cultivars Golden Bliss, Polana, Fallgold, Schönemann, and Bababerry, grown on cultivation medium added of 4 g L-1 activated charcoal, due to the absorption of phenolic compounds released into the culture medium.A propagação da framboeseira (Rubus idaeus L.) é comumente realizada a partir da estacas de raízes. Embora, os frutos possuam sementes viáveis, a reprodução sexuada não é desejada, em razão, de algumas desvantagens, tais como: dormência, elevada variabilidade genética período de juvenilidade. Dessa forma, a micropropagação in vitro é uma técnica viável para o processo de formação de mudas, pois, preserva características genéticas desejáveis das plantas-matrizes, servindo como uma alternativa para os produtores. Objetivou-se então avaliar o efeito de diferentes concentrações de carvão ativado, suplementado ao meio de cultura para as diferentes cultivares de framboeseira. Utilizaram-se o carvão ativado (0; 2 e 4 g L-1), e as cultivares de framboeseira (Indian Summer, Heritage, Willamette, Golden Bliss, Polana, Fallgold, Schönemann e Bababerry). O delineamento experimental utilizado foi inteiramente casualizado arranjado em esquema bifatorial, com quatro repetições. Cada repetição composta por 25 tubos e um explante por tubo. Melhor controle de oxidação foi observado para as cultivares Golden Bliss, Polana, Fallgold, Schönemann e Bababerry, cultivados em meio de cultura acrescido de 4 g L-1 de carvão ativado, devido a absorção de compostos fenólicos liberados no meio de cultura

Renin angiotensin system and cardiac hypertrophy after sinoaortic denervation in rats

OBJECTIVE: The aim of this study was to evaluate the role of angiotensin I, II and 1-7 on left ventricular hypertrophy of Wistar and spontaneously hypertensive rats submitted to sinoaortic denervation. METHODS: Ten weeks after sinoaortic denervation, hemodynamic and morphofunctional parameters were analyzed, and the left ventricle was dissected for biochemical analyses. RESULTS: Hypertensive groups (controls and denervated) showed an increase on mean blood pressure compared with normotensive ones (controls and denervated). Blood pressure variability was higher in denervated groups than in their respective controls. Left ventricular mass and collagen content were increased in the normotensive denervated and in both spontaneously hypertensive groups compared with Wistar controls. Both hypertensive groups presented a higher concentration of angiotensin II than Wistar controls, whereas angiotensin 1-7 concentration was decreased in the hypertensive denervated group in relation to the Wistar groups. There was no difference in angiotensin I concentration among groups. CONCLUSION: Our results suggest that not only blood pressure variability and reduced baroreflex sensitivity but also elevated levels of angiotensin II and a reduced concentration of angiotensin 1-7 may contribute to the development of left ventricular hypertrophy. These data indicate that baroreflex dysfunction associated with changes in the renin angiotensin system may be predictive factors of left ventricular hypertrophy and cardiac failure

Maternal Health in Women with Gestational Diabetes: Impact on Neonatal Health and Long-Term Outcomes

Introduction: Gestational diabetes is a condition affecting an increasing number of women during pregnancy, characterized by elevated blood glucose levels that were not previously diagnosed. This disorder not only has significant implications for maternal health but can also adversely impact neonatal health. Existing literature suggests that women with gestational diabetes face a higher risk of complications during pregnancy, including hypertension and preterm birth, which can, in turn, affect neonatal outcomes and the long-term health of the newborns. Understanding the effects of gestational diabetes is crucial for developing effective preventive and interventional strategies. Objective: Review was to assess the impact of gestational diabetes on neonatal health and the long-term outcomes associated with this condition. Methodology: The methodology followed the PRISMA checklist to ensure transparency and quality in the review process. Relevant databases, including PubMed, Scielo, and Web of Science, were searched. The following descriptors were used: "gestational diabetes," "neonatal health," "long-term outcomes," "maternal health," and "complications." Articles published in the past 10 years that directly addressed the impacts of gestational diabetes were included. Inclusion Criteria: Studies involving women diagnosed with gestational diabetes and their neonates. Articles discussing the effects of the condition on neonatal health and long-term outcomes. Peer-reviewed publications available in English, Portuguese, or Spanish. Exclusion Criteria: Studies focused on type 1 or type 2 diabetes with no direct connection to gestational diabetes. Articles that did not provide relevant data on neonatal health or long-term outcomes. Publications older than a decade or not peer-reviewed. Results: The results indicated that gestational diabetes is associated with a significant increase in the risk of neonatal complications, such as respiratory disorders and low birth weight. Additionally, neonates of mothers with gestational diabetes had a higher likelihood of developing metabolic and cardiovascular issues later in life. The review also highlighted that effective management of gestational diabetes could mitigate some of these risks, improving outcomes for both mothers and their babies. Conclusion: The review underscored the importance of monitoring and managing gestational diabetes to minimize its negative consequences on neonatal health and long-term outcomes. Evidence suggests that early intervention strategies and ongoing care are essential for improving outcomes for mothers and babies affected by this condition.Introduction: Gestational diabetes is a condition affecting an increasing number of women during pregnancy, characterized by elevated blood glucose levels that were not previously diagnosed. This disorder not only has significant implications for maternal health but can also adversely impact neonatal health. Existing literature suggests that women with gestational diabetes face a higher risk of complications during pregnancy, including hypertension and preterm birth, which can, in turn, affect neonatal outcomes and the long-term health of the newborns. Understanding the effects of gestational diabetes is crucial for developing effective preventive and interventional strategies. Objective: Review was to assess the impact of gestational diabetes on neonatal health and the long-term outcomes associated with this condition. Methodology: The methodology followed the PRISMA checklist to ensure transparency and quality in the review process. Relevant databases, including PubMed, Scielo, and Web of Science, were searched. The following descriptors were used: "gestational diabetes," "neonatal health," "long-term outcomes," "maternal health," and "complications." Articles published in the past 10 years that directly addressed the impacts of gestational diabetes were included. Inclusion Criteria: Studies involving women diagnosed with gestational diabetes and their neonates. Articles discussing the effects of the condition on neonatal health and long-term outcomes. Peer-reviewed publications available in English, Portuguese, or Spanish. Exclusion Criteria: Studies focused on type 1 or type 2 diabetes with no direct connection to gestational diabetes. Articles that did not provide relevant data on neonatal health or long-term outcomes. Publications older than a decade or not peer-reviewed. Results: The results indicated that gestational diabetes is associated with a significant increase in the risk of neonatal complications, such as respiratory disorders and low birth weight. Additionally, neonates of mothers with gestational diabetes had a higher likelihood of developing metabolic and cardiovascular issues later in life. The review also highlighted that effective management of gestational diabetes could mitigate some of these risks, improving outcomes for both mothers and their babies. Conclusion: The review underscored the importance of monitoring and managing gestational diabetes to minimize its negative consequences on neonatal health and long-term outcomes. Evidence suggests that early intervention strategies and ongoing care are essential for improving outcomes for mothers and babies affected by this condition

Cistolitectomia para tratamento de cistolitíase em coelho doméstico (Oryctolagus cuniculus): relato de caso

A formação de urólitos em coelhos domésticos (Oryctolagus cuniculus) é uma ocorrência comum na Medicina Veterinária de Lagomorfos, em parte favorecida pela elevada concentração de cristais na composição da urina associada a uma dieta rica em minerais e pouca ingestão hídrica. Este trabalho tem como objetivo relatar um caso de cálculo vesical nesta espécie enfatizando terapia clínica e cirúrgica do caso. Foi atendido no Hospital Veterinário da Universidade Federal Rural da Amazônia um coelho doméstico tendo como principais queixas a presença de sangue na urina, perda progressiva de apetite e interesse hídrico. Durante o exame clínico foi observada presença de estrutura firme em região abdominal, a qual, após realização de exames de imagem, foi identificada como sendo um cálculo vesical. A partir disso, foi realizado tratamento clínico e cistolitectomia para retirada do urólito, seguida de adequação da dieta. O manejo clínico-cirúrgico adotado neste caso mostrou-se eficaz para a boa recuperação do paciente

A importância do teste da linguinha para a cirurgia de frenotomia em lactentes: revisão de literatura / The importance of tongue test for frenotomy surgery in infants: literature review

A anquiloglossia é o freio lingual encurtado, popularmente conhecido como “língua presa” que interfere na movimentação da língua, e em casos mais graves a limitação interfere na fonação, deglutição, fala e alimentação, dificultando a movimentação da língua na hora da amamentação assim detendo o ganho de peso do bebê. O diagnóstico precoce é feito através do teste da linguinha, utilizando o Protocolo de avaliação do frênulo da língua com escores para bebês.Objetivo deste trabalho é discutir a importância do diagnóstico precoce do teste da linguinha na vida de um neonato, visando complementar a intervenção cirúrgica da frenotomia, para cada caso. Foi realizado levantamento de pesquisa sobre o tema, usando artigos encontrados no Lilacs, Scielo e Google Acadêmico, os resultados através dos estudos consultados ressaltou que em relação a frenctomia convencional, a frenotomia em lactentes proporciona mais benefícios aos mesmos, desde que haja um correto diagnóstico, não foi possível identificar um padrão ouro que diagnostique a anquiloglossia, havendo sempre controvérsias entre os autores. Concluímos que o diagnóstico precoce por meio do protocolo é de suma importância para o tratamento de anquiloglossia, colaborando como bem-estar e a qualidade de vida dos bebes, após a cirurgia de frenotomia.

Specificity of Male Responses to Female Vibratory Signals in two Chinavia Species (Hemiptera: Pentatomidae) is Based on Signal Structure and Narrow Temporal Parameters

In this work, we tested whether variations in temporal pattern and architecture of the vibratory signals favor signals recognition and discrimination in two stinkbug species, Chinavia ubica and C. impicticornis. To relate the level of species recognition with species-specific vibratory signal we exposed males to natural or artificial signals. Different artificial signals were synthesized by changing the basic structure or temporal parameters of typical female calling signals of each species. Signals were transmitted to bean plants and the response of males was observed and recorded by a piezoelectric accelerometer. Results show that changes in temporal patterns of artificial signals significantly reduced the proportion of males responding by emitting the male song. Our results confirm that specific elements of male vibratory signals are critical for female signal recognition and discrimination by males and could contribute to prezygotic isolation in sympatric Chinavia species

Physicochemical profile of honeys from different species of stingless bees from western Pará, Brazilian Amazonia / Perfil físico-químico dos méis de diferentes espécies de abelhas sem ferrão do Oeste do Pará, Amazônia Brasileira

Stingless honey is a product with a peculiar flavor and quality and its consumption is increasing both as food and as therapeutic and medicinal purposes, particularly in rural communities. This work evaluates the physicochemical profile of different stingless honeys from the Brazilian Amazonia. We analyzed 13 honey samples of the species Melipona interrupta, Scaptotrigona aff. xanthotricha, Melipona sp., Melipona seminigra and Scaptotrigona polystica from different communities in western Pará State, Brazil. We evaluated the physicochemical parameters of moisture, pH, total acidity, electrical conductivity, ash, hydroxymethylfurfural, diastatic activity, total soluble solids, reducing sugar, and apparent sucrose. The physicochemical profiles showed differences between the species studied, despite coming from the same geographical region. Most parameters comply with limits established from the Identity and Quality of Socially Stingless Honey, from the State of Amazonas. Our results contribute to other studies that investigate and qualify honeys from this region, particularly honeys from Scaptotrigona aff. xanthotricha, whose physicochemical characteristics are still little known in the Brazilian Amazonian region