Exploiting volumetric wave correlation for enhanced depth imaging in scattering medium

Imaging an object embedded within a scattering medium requires the correction of complex sample-induced wave distortions. Existing approaches have been designed to resolve them by optimizing signal waves recorded in each 2D image. Here, we present a volumetric image reconstruction framework that merges two fundamental degrees of freedom, the wavelength and propagation angles of light waves, based on the object momentum conservation principle. On this basis, we propose methods for exploiting the correlation of signal waves from volumetric images to better cope with multiple scattering. By constructing experimental systems scanning both wavelength and illumination angle of the light source, we demonstrated a 32-fold increase in the use of signal waves compared with that of existing 2D-based approaches and achieved ultrahigh volumetric resolution (lateral resolution: 0.41 um, axial resolution: 0.60 um) even within complex scattering medium owing to the optimal coherent use of the extremely broad spectral bandwidth (225 nm)

Media 2: Synthetic aperture microscopy for high resolution imaging through a turbid medium

Originally published in Optics Letters on 01 November 2011 (ol-36-21-4263

Media 1: Synthetic aperture microscopy for high resolution imaging through a turbid medium

Originally published in Optics Letters on 01 November 2011 (ol-36-21-4263

Supplement 1: Selective two-photon collagen crosslinking in situ measured by Brillouin microscopy

Expanded Materials and Methods. Supplementary Figs. S1-S4. Originally published in Optica on 20 May 2016 (optica-3-5-469

Media 1: Toward a miniature endomicroscope: pixelation-free and diffraction-limited imaging through a fiber bundle

Originally published in Optics Letters on 01 April 2014 (ol-39-7-1921

Media 2: Toward a miniature endomicroscope: pixelation-free and diffraction-limited imaging through a fiber bundle

Originally published in Optics Letters on 01 April 2014 (ol-39-7-1921

Visualization 1: Selective two-photon collagen crosslinking in situ measured by Brillouin microscopy

3D view of 2P-CXL region. Originally published in Optica on 20 May 2016 (optica-3-5-469

Media 1: High-speed synthetic aperture microscopy for live cell imaging

Originally published in Optics Letters on 15 January 2011 (ol-36-2-148

Media 1: Exploring anti-reflection modes in disordered media

Originally published in Optics Express on 18 May 2015 (oe-23-10-12740

Media 2: High-speed synthetic aperture microscopy for live cell imaging

Originally published in Optics Letters on 15 January 2011 (ol-36-2-148