Bayesian network semantics for Petri nets

Recent work by the authors equips Petri occurrence nets (PN) with probability distributions which fully replace nondeterminism. To avoid the so-called confusion problem, the construction imposes additional causal dependencies which restrict choices within certain subnets called structural branching cells (s-cells). Bayesian nets (BN) are usually structured as partial orders where nodes define conditional probability distributions. In the paper, we unify the two structures in terms of Symmetric Monoidal Categories (SMC), so that we can apply to PN ordinary analysis techniques developed for BN. Interestingly, it turns out that PN which cannot be SMC-decomposed are exactly s-cells. This result confirms the importance for Petri nets of both SMC and s-cells.Fil: Bruni, Roberto. Università degli Studi di Pisa; ItaliaFil: Melgratti, Hernan Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; ArgentinaFil: Montanari, Ugo. Università degli Studi di Pisa; Itali

Concurrency and Probability: Removing Confusion, Compositionally

Assigning a satisfactory truly concurrent semantics to Petri nets with confusion and distributed decisions is a long standing problem, especially if one wants to resolve decisions by drawing from some probability distribution. Here we propose a general solution to this problem based on a recursive, static decomposition of (occurrence) nets in loci of decision, called structural branching cells (s-cells). Each s-cell exposes a set of alternatives, called transactions. Our solution transforms a given Petri net, possibly with confusion, into another net whose transitions are the transactions of the s-cells and whose places are those of the original net, with some auxiliary nodes for bookkeeping. The resulting net is confusion-free by construction, and thus conflicting alternatives can be equipped with probabilistic choices, while nonintersecting alternatives are purely concurrent and their probability distributions are independent. The validity of the construction is witnessed by a tight correspondence with the recursively stopped configurations of Abbes and Benveniste. Some advantages of our approach are that: i) s-cells are defined statically and locally in a compositional way; ii) our resulting nets faithfully account for concurrency.Fil: Bruni, Roberto Hector. Università degli Studi di Pisa; ItaliaFil: Melgratti, Hernan Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; ArgentinaFil: Montanari, Ugo. Università degli Studi di Pisa; Itali

Part II Farmers’ Experiences of the Farm Assessment: Interviews with Farmers

The objective of work package 463 was to test the implementation of the WQ assessment Scheme on regular broiler farms. We assessed the perception and attitudes of farmers towards animal welfare and on-farm assessment, the experience and evaluation of the assessment itself and the relevance and applicability of the results. at the same time animal scientists assessed the welfare of the animals by WQ monitoring instruments. In addition they scored foot pad lesions at the slaughterhouse by way of video imaging. Both studies proceeded in parallel; farmers told, hence, about their real-life experience. It is to be noted that the WQ monitoring instruments were not at their final state, and experiences and comments of the farmers are to be interpreted as reflection and discussion on work in progress. A team of sociologists carried out the study on farmers’ experiences, perception and attitude whereas the assessment of animal welfare was done by animal scientists. the study took place in three countries – Netherlands, Italy and the UK. We choose to focus on broilers for two main reasons. First of all the production cycle of broilers is relatively short and so it is possible to assess the welfare of different flocks within a short time-span and to check more easily any improvement of animal welfare as a result of farmers’ interventions. a second reason for focusing on broilers is that it allows us to link this project to another project where a new way of checking for foot-pad lesions is developed. this is, moreover, a relatively easy manner of checking animal welfare that allows us to lower the burden of three on-farm assessments considerably. In the following we report on the results of the welfare assessment (Part I) and the interviews with farmers about their perception and experience of animal welfare and the welfare assessment (Part II). In both parts we compare the results across the participating countries (Netherlands, Italy and United Kingdom). More in detail information on the national results of welfare assessment and interviews with farmers can be found in the deliverables 4.31.a (farmers’ interviews) and D4.31b (assessment results). as appendixes, we provide the technical and sociological questionnaires and the assessment reports that were sent to the farmers in the different countries. Bettina B. Bock Ingrid de Jon

The moderating effect of economic reputation on middle-status conformity: a study on the Italian film industry

The relationship between an actor’s status and his/her decision to conform to extant social norms of behavior or to deviate from them is a common theme in the managerial and sociological research. Drawing on previous studies that have highlighted the presence of a U- shaped relationship between status and nonconformity, whereby low-status and high-status actors are more likely to deviate from accepted norms of behavior, this paper aims at investigating how reputation moderates the relationship between status and nonconformity. By relying on a sample of more than 1,500 films introduced from 1990 to 2011 by 730 Italian film producing companies, we hypothesize and find that an organization’s economic reputation negatively moderates the curvilinear U-shaped relationship between its status and nonconformity in a way that, for high reputation, the high propensity of a high-status organization to non-conform is mitigated

Dielectric approaches for interactions of protons, positrons, and electrons in cold matter and plasmas

This work investigates the projectile and temperature dependence of the energy loss of charged particles in matter. To this end, we analyze two dielectric approaches which consider the presence of bound and free electrons and the effects of the ionization process. With these approaches, we calculate the energy-loss moments of protons, positrons, and electrons traversing Si, Fe, and Al targets, both in the cold solid phase and in the plasma state. We compare the results from the unified-wave-packet model (UWPM) and the shellwise local plasma approximation (SLPA) on an extensive range of parameters, including low, intermediate, and high projectile energies and target temperatures going from cold solid-state densities to hot plasma with temperatures up to 1000 eV. We reformulate the SLPA to include light-particle restrictions. We give special consideration to the case of positrons and electrons, where the inner-shell effects have not been analyzed in our previous works. Comparisons with experimental results for cold solid targets are presented, and stopping enhancement effects for heated targets are described, showing the physical origin of these effects.Fil: Archubi, Claudio Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Montanari, Claudia Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Arista, N. R.. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentin

Quantitative structure-activity relationships (QSAR) studies of bisbenzamidines with antifungal activity

This paper describes 2D-QSAR and 3D-QSAR studies against Candida albicans and Cryptococcus neofarmans for a set of 20 bisbenzamidines. In the studies of 2D-QSAR with C. albicans it was obtained a correlation between log MIC-1 and lipolo component-Z (r² = 0.68; Q² = 0.51). In the case of C. neofarmans a correlation between log MIC-1 and lipolo component-Z and of Balaban index (r² = 0.85; Q² = 0.6) was obtained. 3D-QSAR studies using CoMFA showed that the steric fields contributed more to the predicted activities for Candida albicans (94.9%) and Cryptococcus neofarmans (97.9%).FAPEMIGCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CNP

Ciliate diversity and behavioural observations from the chemoautotrophic cave ecosystem of Frasassi, (Marche region, Italy)

Chemoautotrophic cave organisms require specific adaptations to tolerate the stress of living in extreme environmental conditions, such as darkness, nutrient and energy limitations, low temperatures (12-13°C), highly variable sulphide concentrations (from 0 up to 415 μM H2S) and toxic levels of gases (H2S, CO2, CH4). To date, due to the difficulties in sampling in such harsh environment, very few studies were performed in order to describe the ciliate communities from caves; these have remained largely unexplored. Thus, the main aims of our study were to characterize for the first time, the ciliates from the sulfide-rich Frasassi cave complex (Marche region, Italy) and to observe possible behavioural differences with their non-cave-dwelling counterpart ciliate species. Four main sampling sites within Frasassi caves were selected: Pozzo dei Cristalli, Lago Verde, Ramo Solfureo and Grotta Solfurea. The ciliate diversity from the site Pozzo dei Cristalli was studied in greater detail for its spatio-temporal distribution, since it is highly diversified and includes several microhabitats represented by small sulfidic (H2S-rich) ponds, streams and springs as well as, deep and shallow muddy, stagnant lakes. Periodic sampling was realised from 2009 to 2011 in the form of water-sediments, picked up by scraping the surface. Classical culturing, silver staining methods and 18S rRNA gene (for some selected species) for phylogenetic analysis were employed. A total of 31 species belonging to 9 classes, 15 orders and 23 genera were identified. Fluctuation of the ciliate communities were mainly recorded at the Pozzo dei Cristalli sites during various sampling occasions, this could be due to changing environmental conditions (mainly H2S concentrations and water levels). Interestingly, it was observed that some species e.g. Urocentrum turbo, Coleps hirtus hirtus, Oxytricha sp, Euplotes sp, showed adaptation for the cave environment (photo-sensitivity, sulphur tolerance, feeding behaviour, morphological difference). Overall, these results provide a platform for various in-depth studies of ciliates to understand potential role in aquatic microhabitats, nature of chemical compounds secreted, dispersal pattern, and adaptations to cave environment

Free living ciliated protists from the chemoautotrophic cave ecosystem of Frasassi (Italy)

This study provides the first report on a community of free-living ciliated protists from the chemoautotrophic cave ecosystem of Frasassi, Italy. This subterranean groundwater ecosystem represents a hotspot of biodiversity that still needs to be fully explored with particular reference to microbial eukaryotes such as protist ciliates. A total of 33 taxa of ciliates were identified along with one species each of flagellate, heliozoans and naked amoebae, from four main sampling sites, namely, Grotta Solfurea (GSO), Lago Verde (LVE), Ramo Solfureo (RSO), and Pozzo dei Cristalli (PDC). The last consists of small microhabitats/ponds presenting different chemical–physical and biological parameters, such as sulfur and nutrient contents and the presence of bacterial biofilms. Furthermore, an analysis of the cryptic ciliate species biosphere as a ‘seedbank’ of diversity against cave ecosystem disturbance was also performed. This study also highlights some peculiar adaptations of cave-dwelling ciliates not described in their noncave-dwelling conspecifics, such as the extreme photosensitivity of Urocentrum turbo, the cannibalism of Coleps hirtus, the variable number of thorns in Aspidisca species as a defensive response to predation, and the frequent reorganization of ciliary structures in Euplotes aediculatus. The 18S rDNA sequences were generated for five species and were compared with those of the noncave-dwelling conspecifics. Finally, our results shed light on the still largely unknown ciliate diversity in the chemosynthesis-based sulfidic groundwater ecosystem of Frasassi

A Comprehensive Review on Copemyl(\uae)

Economic sustainability is of paramount importance in the rapidly evolving therapeutic scenario of multiple sclerosis (MS). Glatiramoids are a class of drugs whose forefather, glatiramer acetate, has been used as a disease modifying drug (DMD) in patients with MS for over 20 years. Its patent expired in 2015; new versions of such drug are nowadays available on the market, potentially contributing to lowering prices and enhancing a better allocation of economic resources. In this review, we analyze the recommendations underlying the approval of both generic drugs and biosimilars by regulatory authorities, and we provide methodological tools to contextualize the design of studies on these new classes of drugs. We examine in more detail the preclinical and clinical data of Copemyl(\uae), a new member of the glatiramoid class, focusing on its biological and immunological properties and illustrating randomized controlled trials that led to its authorization