Numerical evaluation of thermo-hydraulic performance in fin-and-tube compact heat exchangers with different tube cross-sections

This study examined numericallythe Thermal-hydrodynamic properties of airflow in the fin-and-tube compact heat exchangers (FTCHEs) with considering different shapes of tubes in lowReynoldsnumbers. The influence of applying flat, oval and circular tube adjustments on the thermal and hydraulic characteristics of air flow were analyzed on the in-line tube arrangements. Establishing standard conditions, the study compared different geometries based on circular tubes of 10.459 mm diameter tubes with 25.4 mm longitudinal pitches and 25.4 mm transverse pitches. The other geometries of tubes were assumed in a stable and constant state preparing the same heat transfer surface area per unit volume as that of the nominal case. The results showed that the FTCHE with flat tubes gives the best area goodness factor (j/f) with in a certainrange of Reynoldsnumbers. In addition, FTCHE with flat tubes shown the best thermo-hydraulic performance and a significant augmentation of up to 10.83% and 35.63% in the average area goodness factor achieved accompanied by a decrease in the average friction factor of 17.02% and 43.41% in the flat tube case compared to the oval and circle tube shapes, respectively. It is concluded that the average area goodness factorfor the oval tube is about 25.04% higher than that of the circular tube, while the average friction factor for the oval tube is about 26.9% lower than that of the circular tube. This means that the flat tube has a better-combined thermal-hydraulic performance than the oval and circle tube

Molecular characterization of three Vibrio species and study its pathogenic potential in a gnotobiotic Artemia model

Vibriosis remains the main problem in aquaculture industry caused by bacteria from the genus Vibrio. This study was developed to identify and differentiate between the three Vibrio species which are Vibrio harveyi, V. alginolyticus and V. parahaemolyticus by PCR-outer membrane protein (ompW) gene. Three specific bands with size of 643 bp were produced and sequence analysis of three Vibrios used in this study showed high similarities of V. harveyi, V. alginolyticus and V. parahaemolyticus with published sequences, respectively. Thus, ompW gene can be used as phylomarker in differentiating Vibrio isolates. The effect of pathogenicity of local Vibrios strains with different concentrations on host-microbe interaction has been studied in the gnotobitic Artemia. After challenged, investigation revealed that maximum mortality of Artemia was observed at the concentration of 107 CFU/mL with V. parahaemolyticus have a highest mortality rate

Techniques of EMG signal analysis: detection, processing, classification and applications

Electromyography (EMG) signals can be used for clinical/biomedical applications, Evolvable Hardware Chip (EHW) development, and modern human computer interaction. EMG signals acquired from muscles require advanced methods for detection, decomposition, processing, and classification. The purpose of this paper is to illustrate the various methodologies and algorithms for EMG signal analysis to provide efficient and effective ways of understanding the signal and its nature. We further point up some of the hardware implementations using EMG focusing on applications related to prosthetic hand control, grasp recognition, and human computer interaction. A comparison study is also given to show performance of various EMG signal analysis methods. This paper provides researchers a good understanding of EMG signal and its analysis procedures. This knowledge will help them develop more powerful, flexible, and efficient applications

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Ischaemic conditioning and reperfusion injury

The 30-year anniversary of the discovery of 'ischaemic preconditioning' is in 2016. This endogenous phenomenon can paradoxically protect the heart from acute myocardial infarction by subjecting it to one or more brief cycles of ischaemia and reperfusion. Apart from complete reperfusion, this method is the most powerful intervention known for reducing infarct size. The concept of ischaemic preconditioning has evolved into 'ischaemic conditioning', a term that encompasses a number of related endogenous cardioprotective strategies, applied either directly to the heart (ischaemic preconditioning or postconditioning) or from afar, for example a limb (remote ischaemic preconditioning, perconditioning, or postconditioning). Investigations of signalling pathways underlying ischaemic conditioning have identified a number of therapeutic targets for pharmacological manipulation. Over the past 3 decades, a number of ischaemic and pharmacological cardioprotection strategies, discovered in experimental studies, have been examined in the clinical setting of acute myocardial infarction and CABG surgery. The results from many of the studies have been disappointing, and no effective cardioprotective therapy is currently used in clinical practice. Several large, multicentre, randomized, controlled clinical trials on cardioprotection have highlighted the challenges of translating ischaemic conditioning and pharmacological cardioprotection strategies into patient benefit. However, a number of cardioprotective therapies have shown promising results in reducing infarct size and improving clinical outcomes in patients with ischaemic heart disease