13,371 research outputs found

    Quantitative Version of the Oppenheim Conjecture for Inhomogeneous Quadratic Forms

    Full text link
    A quantitative version of the Oppenheim conjecture for inhomogeneous quadratic forms is proved. We also give an application to eigenvalue spacing on flat 2-tori with Aharonov-Bohm flux

    Prediction of HBF-0259 interactions with hepatitis B Virus receptors and surface antigen secretory factors

    Get PDF
    Hepatitis B virus (HBV) is an etiological agent of viral hepatitis, which may lead to cirrhosis, and hepatocellular carcinoma. Current treatment strategies have not shown promising effect to date but various complications such as, drug toxicity-resistance have been reported. Study on newly discovered compounds, with minimal side effects, as specific HBV inhibitors is a fundamental subject introducing new biologic drugs. Here, we aimed to, by prediction, estimate interactions of HBF-0259 as a non-toxic anti-HBV compound on inhibiting the HBV through either interaction with the viral entry or HBsAg secreting factors using In Silico procedure. Molecular docking was performed by Hex 8.0.0 software to predict the interaction energy (Etot) between HBF-0259 and known cellular factors involved in HBV entry and HBsAg secreting factors. Hex 8.0.0 also employed to create protein–protein complexes. These interactions were then used to analyze the binding site of HBF-0259 within the assumed receptors by MGLTools software. Finally, the amino acid sequences involved in this interaction were aligned for any conservancy. Here, we showed that HBF-0259 Etot with CypA (–545.41 kcal/mol) and SCCA1 (499.68 kcal/mol), involved in HBsAg secretion and HBV integration, respectively, was higher than other interactions. Furthermore, HBF-0259 predicted interaction energy was even higher than those of CypA inhibitors. In addition, we claim that preS1 and/or preS2 regions within HBsAg are not suitable targets for HBF-0259. HBF-0259 has higher interaction energy with CypA and SCCA1, even more than other known receptors, co-receptors, viral ligands, and secretory factors. HBF-0259 could be introduced as potent anti-viral compound in which CypA and or SCCA1, as previously shown, are involved. © 2016 Indian Virological Societ

    Allelic forms of merozoite surface protein-3 in Plasmodium falciparum isolates from southeast of Iran

    Get PDF
    Background: Genetic diversity has provided Plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. Merozoite surface protein-3 (MSP-3) has been used to develop vaccines and investigate the genetic diversity regarding P. falciparum malaria in Iran. Objectives: The main goal of this study was to analyze the polymorphic antigen MSP-3 genes across southeast of Iran among four different districts, to identify the differences in the allele frequency and genetic diversity. Materials and Methods: Nested polymerase chain reaction amplification was used to determine polymorphisms of N-terminal region of the MSP-3 gene. A total of 85 microscopically positive P. falciparum infected individuals from southeast of Iran were included in this study. Results: Of the 85 confirmed P. falciparum samples obtained from four different districts, 72 were successfully scored for MSP-3.The MSP-3 allele classes (K1 and 3D7 types) showed comparable prevalence in all districts. Overall frequencies of K1 and 3D7 allele classes were 94.5 % for both. Conclusions: Since no study has yet looked at the extent of P. falciparum MSP-3 in this geographic region, these data can be helpful to support development of a vaccine based on MSP-3 against malaria. There should be a comparative analysis in different seasonal peaks to indicate the allelic polymorphism of MSP-3 over a period. © 2014, Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp

    Running of the Spectral index in Deformed Matter Bounce Scenarios with Hubble-rate-dependent Dark Energy

    Full text link
    As a deformed matter bounce scenario with a dark energy component we propose a deformed one with running vacuum model (RVM) in which the dark energy density is written as a power series of H2H^2 and H˙\dot H with a constant equation of state parameter same as the cosmological constant. Our results in analytical and numerical point of views show that in some cases same as LCDM bounce scenario, although the spectral index may achieve a good consistency with observations, a positive value of running of spectral index is obtained which is not compatible with inflationary paradigm where it predicts a small negative value for αs\alpha_s. However, by extending the power series up to H4H^4, ρΛ=n0+n2H2+n4H4\rho_{\Lambda}=n_0+n_2 H^2+n_4 H^4, and estimating a set of consistent parameters, we obtain the spectral index nsn_s, a small negative value of running αs\alpha_s and tensor to scalar ratio rr, which these reval a degeneracy between deformed matter bounce scenario with RVM-DE and inflationary cosmology.Comment: 27 pages, 6 figure