CANCER IMMUNOLOGY AND IMMUNOTHERAPY – UNDERSTANDING AND ADAPTATION THE CURRENT EVIDENCE TO OPTIMIZE PATIENT THERAPY OUTCOMES

The aim of this publication includes the try to act as intermediary to the readers, which should be able to understand: - The description of the cancer immunotherapy mechanisms in the context of current therapy decisions for the treatment of cancer - The including criteria for those patients with cancer who could be appropriate candidates for immunotherapy - And to optimize patient outcomes by using best practices to manage the adverse events associated with immunotherapy treatment More than 15 promising immunotherapy approaches being tested in clinical trials with appropriate patients and colleagues for enrollment and peer-to-peer education purposes, respectively

Generalized Calogero-Moser-Sutherland models from geodesic motion on GL(n, R) group manifold

It is shown that geodesic motion on the GL(n, R) group manifold endowed with the bi-invariant metric d s^2 = tr(g^{-1} d g)^2 corresponds to a generalization of the hyperbolic n-particle Calogero-Moser-Sutherland model. In particular, considering the motion on Principal orbit stratum of the SO(n, R) group action, we arrive at dynamics of a generalized n-particle Calogero-Moser-Sutherland system with two types of internal degrees of freedom obeying SO(n, R) \bigoplus SO(n, R) algebra. For the Singular orbit strata of SO(n, R) group action the geodesic motion corresponds to certain deformations of the Calogero-Moser-Sutherland model in a sense of description of particles with different masses. The mass ratios depend on the type of Singular orbit stratum and are determined by its degeneracy. Using reduction due to discrete and continuous symmetries of the system a relation to II A_n Euler-Calogero-Moser-Sutherland model is demonstrated.Comment: 16 pages, LaTeX, no figures. V2: Typos corrected, two references added. V3: Abstract changed, typos corrected, a few formulas and references added. The presentation in the last section has been clarified and it was restricted to the case of GL(3, R) group, the analysis of GL(4, R) will be given elsewhere. V4: Minor corrections in the whole text, more formulas and references added, accepted for publication in PL

In vivo spectroscopy and NMR metabolite fingerprinting approaches to connect the dynamics of photosynthetic and metabolic phenotypes in resurrection plant Haberlea rhodopensis during desiccation and recovery.

International audienceThe resurrection plant Haberlea rhodopensis was used to study dynamics of drought response of photosynthetic machinery parallel with changes in primary metabolism. A relation between leaf water content and photosynthetic performance was established, enabling us to perform a non-destructive evaluation of the plant water status during stress. Spectroscopic analysis of photosynthesis indicated that, at variance with linear electron flow (LEF) involving photosystem (PS) I and II, cyclic electron flow around PSI remains active till almost full dry state at the expense of the LEF, due to the changed protein organization of photosynthetic apparatus. We suggest that, this activity could have a photoprotective role and prevent a complete drop in adenosine triphosphate (ATP), in the absence of LEF, to fuel specific energy-dependent processes necessary for the survival of the plant, during the late states of desiccation. The NMR fingerprint shows the significant metabolic changes in several pathways. Due to the declining of LEF accompanied by biosynthetic reactions during desiccation, a reduction of the ATP pool during drought was observed, which was fully and quickly recovered after plants rehydration. We found a decline of valine accompanied by lipid degradation during stress, likely to provide alternative carbon sources for sucrose accumulation at late stages of desiccation. This accumulation, as well as the increased levels of glycerophosphodiesters during drought stress could provide osmoprotection to the cells