Оцінка якості надання медичної допомоги хворим стаціонарних відділень Сумської ЦРКЛ на основі цільового соціологічного опитування

У загальносвітових тенденціях стосовно покращання якості медичної допомоги превалює залучення механізмів безпосереднього впливу у самому закладі охорони здоров’я через систематичне оцінювання роботи персоналу та вивчення думки пацієнтів. Мета: визначити оцінку задоволеності пацієнтів стаціонарних відділень якістю медичної допомоги на основі цільового соціологічного опитування

A New α-Seleno- or Nonselenoperfluoroacyl Olefination of Aldehydes and Ketones Using β-Ethoxy-β-perfluoroalkyl Vinylic Selenides

A New α-Seleno- or Nonselenoperfluoroacyl Olefination of Aldehydes and Ketones Using β-Ethoxy-β-perfluoroalkyl Vinylic Selenide

A New 3-(Phenylseleno)allylic Cation: Its Regioselective C−C Bond Formation Reaction with Nucleophiles

Highly useful C−C bond formation using 2-ethoxy-3-(phenylseleno)prop-2-enal acetal 2 was examined with various Lewis acids. The reaction of 2 with the silyl enol ether in the presence of BF3·Et2O, ZnBr2, or SnBr4 regioselectively provided (Z)-3,4-diethoxy-5-(phenylseleno)pent-4-enophenone 5a in high yields. On the other hand, the reaction with other Lewis acids such as EtAlCl2 or SnCl4 gave 5-(phenylseleno)- 6 or non-selenopentane-1,4-dione 7, respectively. Novel prop-2-enal acetals 2−4 and 13−15 reacted with various nucleophiles to give pent-4-enophenones 5a,b, 10a, 12, and 16−18, S-ethyl pent-4-enoate 5b, alkylated vinylic sulfide 10b, 3-pentenenitrile 5d, and 10c. A versatile pent-4-enophenone 5a could be converted to tetrahydrofuran 20 and penta-2,4-dienophenone 19, the Diels−Alder reactions of which with dienophiles gave the adducts 24 and 25

New Cyclization of 4-Oxahepta-1,6-diynes Bearing Sulfur and Selenium Functional Groups

New cyclizations of 1-sulfanyl- and -selanyl-4-oxa-1,6-heptadiynes using sodium alkoxide or thiolates provided 4-alkoxymethyl-3-phenylsulfanyl- and 3,4-bis(sulfanylmethyl)furans in high yields

Novel Perfluoroacyl Olefinations of Aldehydes Using β-Thio-Substituted Perfluoroalkyl Enol Ethers

α-(Methylthio)- or α-(phenylthio)-substituted perfluoroacylolefinations of nonenolizable aldehydes using the β-lithio-β-thio-perfluoroalkyl enol ethers 1−4 stereoselectively proceeded to give (Z)-α,β-unsaturated perfluoroalkyl ketones 9a−e, 10a−c, 11a−c, and 12a. The α-(thio)-α,β-unsaturated trifluoromethyl ketones were easily converted to 3-(thio)-2-(trifluoromethyl)-1,3-butadienes 21a−c and 22a,b in moderate to high yields (41−85%)

A New 1-Alkoxy-2-(chalcogeno)allylic or 1-Alkoxy-2,4-bis(chalcogeno)penta-2,4-dienyl Cation: Highly-Regioselective Allylating or Penta-2,4-dienylating Electrophiles and Their Reactions

2-(Chalcogeno)-1-ethoxyallylic cations 4A are easily generated from the reactions of 2-(chalcogeno)-1-ethoxyprop-1-en-3-ols 2a−e or 2-(chalcogeno)prop-2-enal acetals 3a−c and TMSOTf and reacted with various nucleophiles to give the adducts 5a−8a, 5b−11b, and 5c−e regio and stereoselectively. 2,4-Bis(chalcogeno)penta-2,4-dienal acetals 16a,c and the 2,4,6-tris(phenylthio)hepta-2,4,6-trienal acetal 20c also gave the dienones 17a,c and 21c in good yields. Furthermore, the intramolecular cyclization of the alkenyl alcohols 25a,b and the 2,4-dienal 2,4-dinitrophenyl hydrazones 29a−c afforded the tetrahydrofurans 26a,b and 3,5-bis(chalcogeno)pyridines 30a−c, respectively

A New 1-Alkoxy-2-(chalcogeno)allylic or 1-Alkoxy-2,4-bis(chalcogeno)penta-2,4-dienyl Cation: Highly-Regioselective Allylating or Penta-2,4-dienylating Electrophiles and Their Reactions

2-(Chalcogeno)-1-ethoxyallylic cations 4A are easily generated from the reactions of 2-(chalcogeno)-1-ethoxyprop-1-en-3-ols 2a−e or 2-(chalcogeno)prop-2-enal acetals 3a−c and TMSOTf and reacted with various nucleophiles to give the adducts 5a−8a, 5b−11b, and 5c−e regio and stereoselectively. 2,4-Bis(chalcogeno)penta-2,4-dienal acetals 16a,c and the 2,4,6-tris(phenylthio)hepta-2,4,6-trienal acetal 20c also gave the dienones 17a,c and 21c in good yields. Furthermore, the intramolecular cyclization of the alkenyl alcohols 25a,b and the 2,4-dienal 2,4-dinitrophenyl hydrazones 29a−c afforded the tetrahydrofurans 26a,b and 3,5-bis(chalcogeno)pyridines 30a−c, respectively

The First Example of the 1-Chalcogene-Substituted Formylolefination of the Ketones and Aldehydes Using 1-Lithio-2-ethoxyvinyl Chalcogenides

The α-chalcogene-substituted formylolefinations of ketones and aldehydes proceeded using 1-lithio-2-ethoxyvinyl chalcogenides/PPSE or TMSOTf to produce the α-chalcogenoformylolefinated products 4a−l in high yields. Tandem-formylolefination provided the (2Z,4Z)-2,4-bis(chalcogeno)pent-2,4-dienals 5d,h,i and (2Z,4Z,6Z)-2,4,6-tris(phenylthio)hept-2,4,6-trienal derivatives 7d and 8d, respectively

Scandium-Catalyzed Carbon−Carbon Bond-Forming Reactions of 3-Sulfanyl- and 3-Selanylpropargyl Alcohols

The scandium-catalyzed substitution reactions of the phenylsulfanyl and phenylselanyl propargyl alcohols 3a−i and 7a−h regioselectively proceeded to give the propargylated compounds 4 and 8 in high yields

Scandium-Catalyzed Carbon−Carbon Bond-Forming Reactions of 3-Sulfanyl- and 3-Selanylpropargyl Alcohols

The scandium-catalyzed substitution reactions of the phenylsulfanyl and phenylselanyl propargyl alcohols 3a−i and 7a−h regioselectively proceeded to give the propargylated compounds 4 and 8 in high yields