Environmental applications of nanocellulose scaffolded metal organic frameworks (MOFs@NC)

Metal organic frameworks (MOFs) have gained tremendous attention due to large surface area, porous structure, high chemical and thermal stability. Unfortunately, susceptible to agglomeration, poor recyclability and fixed porous size severely limit their performance and corresponding applications. Derived from earth’s most abundant polymeric biomass, nanocelluloses (NC) not only provides green and biocompatible supporting matrix to prevent agglomeration, but also offers mechanical stability, large accessible porosity and malleable properties for MOFs, synergistically resulting in wide applications of MOFs@NC composite especially in the field of environmental remediation. Herein, this paper mainly reviews 1) synthesis and physiochemical properties of MOFs@NC; 2) removal applications of heavy metals, organic pollutants and particulate matters together with gas separation and 3) adsorption, degradation and separation mechanisms of MOFs@NC through decontamination processes. Finally, potential opportunities for future research of MOFs@NC are proposed.</p

Table_2_The global research and emerging trends in autophagy of pancreatic cancer: A bibliometric and visualized study.docx

ObjectiveTo present the global research features and hotspots, and forecast the emerging trends by conducting a bibliometric analysis based on literature related to autophagy of pancreatic cancer from 2011 to 2022.MethodsThe literature data regarding autophagy of pancreatic cancer were retrieved and downloaded from the Web of Science Core Collection (WOSCC) from Clarivate Analytics on June 10th, 2022. VOSviewer (version 1.6.18) was used to perform the bibliometric analysis.ResultsA total of 616 studies written by 3993 authors, covered 45 countries and 871 organizations, published in 263 journals and co-cited 28152 references from 2719 journals. China (n=260, 42.2%) and the United States (n=211, 34.3%) were the most frequent publishers and collaborated closely. However, publications from China had a low average number of citations (25.35 times per paper). The output of University of Texas MD Anderson Cancer Center ranked the first with 26 papers (accounting for 4.2% of the total publications). Cancers (n=23, 3.7%; Impact Factor = 6.639) published most papers in this field and was very pleasure to accept related researches. Daolin Tang and Rui Kang published the most papers (n=18, respectively). The research hotspots mainly focused on the mechanisms of autophagy in tumor onset and progression, the role of autophagy in tumor apoptosis, and autophagy-related drugs in treating pancreatic cancer (especially combined therapy). The emerging topics were chemotherapy resistance mediated by autophagy, tumor microenvironment related to autophagy, autophagy-depended epithelial-mesenchymal transition (EMT), mitophagy, and the role of autophagy in tumor invasion.ConclusionAttention has been increasing in autophagy of pancreatic cancer over the past 12 years. Our results undoubtedly provide scholars with new clues and ideas in this field.</p

Table_1_The global research and emerging trends in autophagy of pancreatic cancer: A bibliometric and visualized study.docx

ObjectiveTo present the global research features and hotspots, and forecast the emerging trends by conducting a bibliometric analysis based on literature related to autophagy of pancreatic cancer from 2011 to 2022.MethodsThe literature data regarding autophagy of pancreatic cancer were retrieved and downloaded from the Web of Science Core Collection (WOSCC) from Clarivate Analytics on June 10th, 2022. VOSviewer (version 1.6.18) was used to perform the bibliometric analysis.ResultsA total of 616 studies written by 3993 authors, covered 45 countries and 871 organizations, published in 263 journals and co-cited 28152 references from 2719 journals. China (n=260, 42.2%) and the United States (n=211, 34.3%) were the most frequent publishers and collaborated closely. However, publications from China had a low average number of citations (25.35 times per paper). The output of University of Texas MD Anderson Cancer Center ranked the first with 26 papers (accounting for 4.2% of the total publications). Cancers (n=23, 3.7%; Impact Factor = 6.639) published most papers in this field and was very pleasure to accept related researches. Daolin Tang and Rui Kang published the most papers (n=18, respectively). The research hotspots mainly focused on the mechanisms of autophagy in tumor onset and progression, the role of autophagy in tumor apoptosis, and autophagy-related drugs in treating pancreatic cancer (especially combined therapy). The emerging topics were chemotherapy resistance mediated by autophagy, tumor microenvironment related to autophagy, autophagy-depended epithelial-mesenchymal transition (EMT), mitophagy, and the role of autophagy in tumor invasion.ConclusionAttention has been increasing in autophagy of pancreatic cancer over the past 12 years. Our results undoubtedly provide scholars with new clues and ideas in this field.</p

Supplemental Materials from Sex-Specific Association between Family History of Diabetes and Risk of Colorectal Cancer: Two Prospective Cohort Studies

Supplemental Methods</p

Transforming Racemic Compounds into Two New Enantioenriched Chiral Products via Intermediate Kinetic Resolution

Converting racemic compounds to enantioenriched products is an important and economic approach for accessing enantioenriched chiral molecules. A common method is kinetic resolution. Herein, we present a mode of kinetic resolution that transforms racemic compounds into enantioenriched products, in which the kinetic resolution of reaction intermediates is the key. Catalyzed by a single Ru complex, racemic allylic alcohols are shown to react with a glycine-derived Schiff base to afford two chiral compounds, a δ-carbonyl product and a δ-hydroxy variant, with good yields and stereoselectivities (up to >20:1 dr, 99% ee, 920 s factor). Mechanistic studies suggest that multiple hydrogen transfer events exist in the reaction: a dehydrogenative coupling process, which leads to a pair of racemic intermediates, and a transfer hydrogenation-enabled kinetic resolution process that resolves the intermediates, alongside H2 release at the catalyst

Transforming Racemic Compounds into Two New Enantioenriched Chiral Products via Intermediate Kinetic Resolution

Converting racemic compounds to enantioenriched products is an important and economic approach for accessing enantioenriched chiral molecules. A common method is kinetic resolution. Herein, we present a mode of kinetic resolution that transforms racemic compounds into enantioenriched products, in which the kinetic resolution of reaction intermediates is the key. Catalyzed by a single Ru complex, racemic allylic alcohols are shown to react with a glycine-derived Schiff base to afford two chiral compounds, a δ-carbonyl product and a δ-hydroxy variant, with good yields and stereoselectivities (up to >20:1 dr, 99% ee, 920 s factor). Mechanistic studies suggest that multiple hydrogen transfer events exist in the reaction: a dehydrogenative coupling process, which leads to a pair of racemic intermediates, and a transfer hydrogenation-enabled kinetic resolution process that resolves the intermediates, alongside H2 release at the catalyst

Characteristics of individuals with a lower GI biopsy of normal mucosa and their matched population references and unexposed full siblings.

Characteristics of individuals with a lower GI biopsy of normal mucosa and their matched population references and unexposed full siblings.</p

Supplementary figures and tables.

Fig A. Standardized cumulative incidence and 95% CI of inflammatory bowel disease in individuals with a GI biopsy result of normal mucosa (pink) and their matched population references (blue), stratified by sex, age at index date, or calendar period at index date. Table A. ICD codes and SNOMED codes defining IBD. Table B. Definitions of endoscopy, colectomy, and proctocolectomy. Table C. ICD codes assigned for phenotypes of IBD. Table D. Anatomical Therapeutic Chemical codes representing IBD treatment. Table E. Incidence rate of IBD in individuals with a GI biopsy result of normal mucosa and their matched population references. Table F. Incidence rate of IBD in individuals with a GI biopsy result of normal mucosa and their unexposed full siblings. Table G. Cumulative incidence and 95% CI of IBD during follow-up in individuals with a GI biopsy result of normal mucosa, compared with their matched population references. Table H. Cumulative incidence and 95% CI of IBD during follow-up in individuals with a GI biopsy result of normal mucosa, compared with their unexposed full siblings. Table I. Subgroup analyses of IBD during follow-up in individuals with a lower GI biopsy result of normal mucosa, compared with their matched population references. Table J. Subgroup analyses of IBD during follow-up in individuals with a lower GI biopsy result of normal mucosa, compared with their unexposed full siblings. Table K. Associations between lower GI biopsy result of normal mucosa and risk of IBD phenotypes, compared with their matched population references. Table L. Characteristics of individuals with an upper GI biopsy of normal mucosa and their matched population references and unexposed full siblings. Table M. Sensitivity analyses of IBD during follow-up in individuals with a lower GI biopsy result of normal mucosa, compared with their matched population references. (DOCX)</p

Supplementary Data from Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas

Figure S1, Figure S2, Table S1, Table S2, Table S3, Table S4</p

Supplementary Methods and tables from Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women

This file contains supplementary methods on assessment of dietary and lifestyle factors, and supplementary table 1 (Stratified association of plasma MIC-1 level with risk of advanced colorectal adenomas in the Nurses' Health Study (1990-2008)).</p