Supplemental Material - Effects of scutellarin on acute myocardial ischemia/reperfusion injury in isolated rat heart

Supplemental Material for Effects of scutellarin on acute myocardial ischemia/reperfusion injury in isolated rat heart by Daoxu Qu, Peiwen Feng, Xinjie Zhang and Mingjie Zhou in European Journal of Inflammation</p

Data_Sheet_1_Openness and Entrepreneurial Performance During COVID-19 Pandemic: Strategic Decision Comprehensiveness as an Inconsistent Mediator.PDF

The COVID-19 pandemic severely hit small and micro-businesses. In the face of the impact of the pandemic, how to help entrepreneurs, especially small- and micro-businesses that are more sensitive to the impact of the pandemic, make decisions to reduce losses has become an issue worth paying attention to. From the perspective of personality approach, this article studied openness, which is the strongest predictor of entrepreneurial performance among the big five personality traits, and explored the impact of entrepreneurs’ openness on entrepreneurial performance during the COVID-19 pandemic, as well as the inconsistent mediating role of strategic decision comprehensiveness on entrepreneurial performance. An online questionnaire survey was conducted among 238 entrepreneurs of small- and micro-businesses when China was recovering from the pandemic and starting to resume work and production (February 18 – February 26, 2020). Entrepreneurial performance during the COVID-19 pandemic was measured by comparing the business conditions before and after the pandemic. The results showed that entrepreneurs’ openness positively impacted strategic decision comprehensiveness and entrepreneurial performance during the COVID-19 pandemic. Among the two competing hypotheses proposed by summarizing previous research, the results supported that strategic decision comprehensiveness negatively affected entrepreneurial performance. It indicated that entrepreneurs who tend to collect and analyze information extensively and then make decisions during the pandemic could not seize opportunities and improve their entrepreneurial performance. The results further supported that strategic decision comprehensiveness was an inconsistent mediator between openness and entrepreneurial performance, showing that entrepreneurs with low openness can also reduce the loss of entrepreneurial performance during the pandemic by making incomplete but rapid strategic decisions. This study found that the openness of entrepreneurs had a positive impact on strategic decision comprehensiveness for the first time and provided more empirical evidence for the negative effect of strategic decision comprehensiveness on entrepreneurial performance in the context of information uncertainty and unanalyzable situations. The inconsistent mediating effect of strategic decision comprehensiveness revealed in this study also has practical significance for helping entrepreneurs make correct decisions to reduce the losses caused by the pandemic.</p

Potential Antihypertensive Mechanisms of the Egg White-Derived Peptide QIGLF in Spontaneously Hypertensive Rats Revealed Using Untargeted Serum Metabolomics

The angiotensin-converting enzyme (ACE) inhibitory peptide QIGLF derived from egg white was shown to have significant in vivo antihypertensive effects in our previous study, but the intervention mechanisms at the metabolic level are still unclear. The UPLC-QTOF/MS-based untargeted metabolomics approach was used to clarify the potential antihypertensive mechanisms of QIGLF in the serum of spontaneously hypertensive rats (SHRs). Multivariate statistical analysis showed a clear difference in the metabolite profiles between the QIGLF and model groups. The results suggested that eight potential biomarkers were identified, that is, adrenic acid, ursodeoxycholic acid, glycocholic acid, taurocholic acid, tryptophan, acetylindoxyl, tyrosine, and 2-phenylethanol, which were mainly involved in aromatic amino acid biosynthesis and metabolism, biosynthesis of bile acid, and biosynthesis of unsaturated fatty acids. QIGLF might exert antihypertensive effects by improving endothelial dysfunction. This study provides a theoretical basis for future research and application of ACE inhibitory peptides in the prevention and improvement of hypertension

Effects of Scu on mRNA expressions of ACE, AT1R, TNF- α, IL-6, and IL-1β after 24 h of pMCAO.

<p>Graphical representation of fold change of ACE mRNA. Each bar represents means ±S. D., ^##P < 0.01 vs. sham group, *P < 0.05, **P < 0.01 vs. model group.</p

Molecular mode of Scu in the binding site of ACE.

<p>The dashed lines show the formation and distance of hydrogen bonds. Active site amino acid residues represent lines.</p

Data_Sheet_1_COVID-19 symptoms and compliance: The mediating role of fundamental social motives.ZIP

BackgroundUnderstanding the compliance of infected individuals and the psychological process underlying compliance during pandemics is important for preventing and controlling the spread of pathogens. Our study investigated whether fundamental social motives mediate the relationship between having infectious disease and compliance.MethodsAn online survey was conducted in March 2020, during the severe phase of the COVID-19 outbreak in China to collect data from 15,758 participants. The survey comprised self-report questionnaires with items pertaining to current symptoms (COVID-19 symptoms, other symptoms or no symptoms), the Fundamental Social Motive Inventory, and measures of compliance. Correlation analysis, linear regression analysis, and structural equation model were used for data analysis.ResultsThe participants with COVID-19 symptoms had lower levels of compliance than those without symptoms, and their lower compliance was caused by a decrease in disease avoidance (indirect effect = −0.058, 95% CI = [−0.061, −0.056]) and familial motives (indirect effect = −0.113, 95% CI = [−0.116, −0.062]). Whereas exclusion concern (indirect effect = 0.014, 95% CI = [0.011, 0.017]) suppressed the effects of COVID-19 symptoms on compliance, the effect disappeared in the multiple mediation model, while those of disease avoidance and familial motives remained.ConclusionOur findings emphasize the critical role of disease avoidance and familial motives in promoting compliance with public health norms during pandemics and suggest that enhancing these motives may serve as an effective intervention strategy to mitigate noncompliance among potentially infected individuals.</p

Effects of Scu on cerebral blood flow.

<p>(A) Laser scanning images of CBF in whole cortex 24 h after operation in sham-operated rat, pMCAO rat and pMCAO rat administrated with 100, 50 and 25mg/kg Scu. CBF recovery can be seen in the pMCAO rat received 100, 50 mg/kg Scu. (B) Ischemic hemisphere showed significant higher blood flow in pMCAO rat received 100, 50 mg/kg Scu when compared with model group. Data are expressed as mean ± S.D. ^##P < 0.01 vs. sham, **P<0.01 vs. model.</p

Direct Urea/H₂O₂ Fuel Cell with a Hierarchical Porous Nanoglass Anode for High-Efficiency Energy Conversion

Direct urea/H2O2 fuel cells (DUFCs) constitute a sustainable bifunctional energy conversion technique devoted to simultaneously eliminating environmental wastewater with urea and generating clean energy. However, exploring an efficient anode material for DUFCs still remains a huge challenge. In this work, a Ni–P hierarchical porous nanoglass (HPNG) catalytic electrode was developed via a low-cost, industrially available electrodeposition technique, which exhibits one of the best performances reported so far in the urea oxidation reaction (UOR), with a potential of 1.330 V at a current density of 10 mA cm–2 and a Tafel slope of 9.77 mV dec–1. The superior UOR performance of the HPNG electrode is attributed to the excellent intrinsic catalytic activity of NG with a high-energy state and an extremely enlarged surface area from the unique 3D hierarchical porous structure. Furthermore, a DUFC system with the HPNG anode shows a performance breakthrough as indicated by the maximum power density of 38.15 mW cm–2 for 0.5 M urea, representing one of the best yet reported DUFCs. Our work demonstrates the feasibility of the scalable production of HPNG electrodes and is expected to be a great contribution to the development of the practical use of DUFCs in the near future for bifunctional energy conversion

Effects of Scu on blood pressure in pMCAO rat.

<p>The SBP was measured by noninvasive blood pressure system at three time points in pMCAO rat: 1 h before administrated on day 1, seven days after administered and 24 h after pMCAO surgery. There was no significant difference between pMCAO rat with Scu administrated and without Scu treatment.</p

Effects of Scu on permanent focal cerebral ischemia in rats.

<p>(A) Representative coronal brain sections stained with TTC after 24 h of pMCAO. Red-colored region in the TTC-stained sections indicates no ischemic portion of brain, and pale-colored region indicates ischemic portion. (B) Evaluation of infarct area 24 h after pMCAO. Infarct areas were measured using Photoshop image analysis software. (C) Neuroprotective effects of Scu on neurological deficit scores in pMCAO rats. Data are expressed as means ±S.D, ^##P < 0.01 vs. sham group, *P < 0.05, **P < 0.01 vs. model group, n = 8.</p