Metal-Free Activation of Sulfite by Benzoquinone-Derived Carbon for Efficient Organic Contaminant Degradation: Identification and Regulation of Active Sites

Sulfite [S­(IV)]-based advanced oxidation processes (AOPs) driven by carbon materials provide an environmentally friendly, economical route for environmental remediation. However, the active sites and involved radical mechanisms are still controversial due to the complexity of the carbon structure, thus greatly hampering the development of highly efficient systems. Herein, a benzoquinone-derived carbon (BQC)/S­(IV) system was developed for organic pollutant degradation in an acidic medium for the first time. The quinone groups and conductivity were confirmed as the key factors for S­(IV) activation through cyclic voltammetry, antitheses, specific site masking, and quantitative structure–activity relationship methods. Benefiting from the high content of quinone groups and excellent conductivity, the BQC catalyst exhibited much more effective in activating Na2SO3 for organic pollutant degradation compared to most traditional carbon or even metal catalysts. The chronopotentiometry and in situ Raman results revealed that the formation of C–S­(IV)* complexes was the primary step to produce SO3·–, followed by the production of SO4·– via a chain reaction, in which the SO4·– radical was responsible for pollutant degradation. The findings may provide novel insights into reaction mechanisms in S­(IV)-AOP systems and pave the way toward highly efficient carbon catalysts to activate S­(IV) for the elimination of organic contaminants

Post-marketing safety concerns with palbociclib: a disproportionality analysis of the FDA adverse event reporting system

To explore the association between palbociclib and related adverse events (AEs) in the real world through U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database. The signal strength of palbociclib-related AEs was done by disproportionality analysis. Clinical priority of palbociclib-related AEs was scored and ranked by assessing five different features. Outcome analysis, time to onset analysis, dose-report /AEs number analysis, and stratification analysis were all performed. There were 61,821 ‘primary suspected (PS)’ reports of palbociclib and 195,616 AEs associated with palbociclib. The four algorithms simultaneously detected 18 positive signals at the SOC level, and 65 positive signals at the PT level. Bone marrow failure, neuropathy, peripheral, pleural effusion, myelosuppression, pulmonary edema, and pulmonary thrombosis were also found to have positive signals. Gender (female vs male, χ2 = 5.287, p = 0.022) and age showed significant differences in serious and non-serious reports. Palbociclib-related AEs had a median onset time of 79 days (interquartile range [IQR] 20–264 days). The study identified potential Palbociclib-related AEs and offered warnings for special AEs, providing further data for palbociclib safety studies in breast cancer patients. Nonetheless, prospective clinical trials are needed to validate these results and explain their relationship.</p

Supplementary document for Mechanoluminescence from highly transparent ZGO:Cr spinel glass ceramics - 5760660.pdf

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Supplementary document for Mechanoluminescence from highly transparent ZGO:Cr spinel glass ceramics - 5926874.pdf

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Additional file 1 of Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice

Additional file 1. Ethics approval documen

SlMYB7, an AtMYB4-Like R2R3-MYB Transcription Factor, Inhibits Anthocyanin Accumulation in <i>Solanum lycopersicum</i> Fruits

Tomato is a horticultural crop with an incomplete flavonoid metabolic pathway that does not typically accumulate anthocyanins in the fruit. In recent years, intensive studies of the loci Anthocyanin fruit (Aft) and atroviolacium (atv) have clarified the functions of positive regulators (R2R3-MYBs) and a negative regulator (CPC-MYB) in anthocyanin biosynthesis in the fruits. However, little is known about the R2R3-MYB repressors. Here, we used transient overexpression analysis to show that SlMYB7, a subgroup 4 AtMYB4-like R2R3-MYB, inhibited anthocyanin accumulation and reduced expression of anthocyanin synthase genes in the ‘black pearl’ tomato fruits, which usually accumulate high concentrations of anthocyanins. These findings revealed that SlMYB7 served as a repressor of anthocyanin production. Furthermore, SlMYB7 actively repressed SlANS expression by binding its promoter and passively inhibited anthocyanin synthesis by interacting with the basic helix–loop–helix (bHLH) proteins SlJAF13 and SlAN1, which are involved in the formation of MBW complexes. Thus, SlMYB7 and the MBW complex may coregulate the anthocyanin content of ‘black pearl’ tomato fruits via a negative feedback loop. These findings provide a theoretical basis for the future enhancement of tomato anthocyanin contents through genetic manipulation of the biosynthetic regulatory network

Table_1_OxyR contributes to virulence of Acidovorax citrulli by regulating anti-oxidative stress and expression of flagellin FliC and type IV pili PilA.docx

In many bacteria, OxyR acts as a transcriptional regulator that facilitates infection via degrading hydrogen peroxide (H2O2) generated by the host defense response. Previous studies showed that OxyR also plays an important role in regulating biofilm formation, cell motility, pili relate-genes expression, and surface polysaccharide production. However, the role of OxyR has not been determined in Acidovorax citrulli strain xjl12. In the current study, the qRT-PCR and western blot assays revealed that the expression level of oxyR was significantly induced by H2O2. The oxyR deletion mutant of A. citrulli was significantly impaired bacterial tolerance to oxidative stress and reduced catalase (CAT) activity. In addition, oxyR mutant resulted in reduced swimming motility, twitching motility, biofilm formation, virulence, and bacterial growth in planta by significantly affecting flagellin and type IV pili-related gene (fliC and pilA) expression. The qRT-PCR assays and western blot revealed that OxyR positively regulated the expression of fliC and pilA. Furthermore, bacterial one-hybrid assay demonstrated that OxyR directly affected pilA and fliC promoter. Through bacterial two-hybrid assay, it was found that OxyR can directly interact with PilA and FliC. These results suggest that OxyR plays a major role in the regulating of a variety of virulence traits, and provide a foundation for future research on the global effects of OxyR in A. citrulli.</p

SlMYB7, an AtMYB4-Like R2R3-MYB Transcription Factor, Inhibits Anthocyanin Accumulation in <i>Solanum lycopersicum</i> Fruits

Tomato is a horticultural crop with an incomplete flavonoid metabolic pathway that does not typically accumulate anthocyanins in the fruit. In recent years, intensive studies of the loci Anthocyanin fruit (Aft) and atroviolacium (atv) have clarified the functions of positive regulators (R2R3-MYBs) and a negative regulator (CPC-MYB) in anthocyanin biosynthesis in the fruits. However, little is known about the R2R3-MYB repressors. Here, we used transient overexpression analysis to show that SlMYB7, a subgroup 4 AtMYB4-like R2R3-MYB, inhibited anthocyanin accumulation and reduced expression of anthocyanin synthase genes in the ‘black pearl’ tomato fruits, which usually accumulate high concentrations of anthocyanins. These findings revealed that SlMYB7 served as a repressor of anthocyanin production. Furthermore, SlMYB7 actively repressed SlANS expression by binding its promoter and passively inhibited anthocyanin synthesis by interacting with the basic helix–loop–helix (bHLH) proteins SlJAF13 and SlAN1, which are involved in the formation of MBW complexes. Thus, SlMYB7 and the MBW complex may coregulate the anthocyanin content of ‘black pearl’ tomato fruits via a negative feedback loop. These findings provide a theoretical basis for the future enhancement of tomato anthocyanin contents through genetic manipulation of the biosynthetic regulatory network

CoSe Nanoparticle Embedded B,N-Codoped Carbon Nanotube Array as a Dual-Functional Host for a High-Performance Li‑S Full Battery

The lithium polysulfide (LiPSs) shuttling and slow chemical reactions at the sulfur cathode and the formation of dendritic lithium in metal anodes severely hinder the popularization of lithium–sulfur batteries. Here, a B,N-codoped carbon nanotube (BNCNTs) array decorated with sulfilic and lithiophilic CoSe nanoparticles grown on a carbon cloth (CoSe@BNCNTs/CC) as both a sulfur and a lithium host is reported. Density functional theory (DFT) calculations, simulations, and electrochemical performance determinations demonstrate that CoSe@BNCNTs/CC can simultaneously exert catalytic effects for accelerating LiPSs conversion and realize smooth and uniform lithium deposition to regulate the S and Li electrochemistry. Moreover, the unique structure of the BNCNTs array provides sufficient storage space for sulfur and homogenizes the distribution of Li ions and the electric field of the electrode. The assembled Li-S full battery with a CoSe@BNCNTs/CC dual-functional host exhibits a long-term cycling stability (800 cycles at 0.5 C with a decay rate of 0.066% per cycle) and a high rate capacity (684 mAh g–1 at 2 C). Even at a high sulfur loading of 7.9 mg cm–2, the Li-S full battery has a high areal capacity of 9.76 mAh cm–2 at 0.2 C. This study proposes a viable strategy to solve the challenges of both S and Li electrodes for practical Li-S full batteries