Cannabinoids help to unravel etiological aspects in common and bring hope for the treatment of autism and epilepsy

Desde 1843 que as propriedades anticonvulsivantes da Cannabis são conhecidas pela ciência ocidental. Em 1980, ensaios clínicos demonstraram que canabidiol possui atividade antiepilética em pacientes de epilepsia refratária, sendo sonolência o único efeito colateral. O embargo imposto pela proibição do uso medicinal da Cannabis, no entanto, prejudicou imensamente o desenvolvimento científico e a exploração dessas propriedades. Multiplicam-se, contudo, os casos bem sucedidos de uso ilegal e sem orientação para o tratamento de síndromes caracterizadas por epilepsia e autismo regressivo. Os resultados corroboram evidências científicas que indicam a existência de processos etiológicos comuns entre o autismo e a epilepsia. Estudos em modelos animais confirmam envolvimento do sistema endocanabinoide. Esses avanços apontam o início de uma revolução no entendimento e tratamento desses transtornos.Since 1843 the anticonvulsant properties of Cannabis are known by the Western science. In 1980, clinical trials have shown that cannabidiol has antiepileptic activity in refractory epilepsy patients, with drowsiness as the only side effect. The embargo imposed by banning medicinal Cannabis use, however, harmed scientific development and the exploration of these properties. However, there is a growing number of successful cases of illegal use without guidance for the treatment of syndromes characterized by epilepsy and regressive autism. The results corroborate scientific evidence that indicates the existence of common etiological aspects between autism and epilepsy. Studies in animal models have confirmed involvement of the endocannabinoid system. These advances indicate the beginning of a revolution in the understanding and treatment of these disorders

Kenya: West Kenya postmarks

HiWATER: The Multi-Scale Observation Experiment on Evapotranspiration over heterogeneous land surfaces (MUSOEXE) Dataset - Flux Observation Matrix (stable isotopic observations

The time-depth of Corded Ware burial landscapes: A comparative study of Single Grave and Battle Axe burial alignments in Denmark, The Netherlands and Sweden

Barrow landscapes appeared in the third and second millennia BC throughout North-Western Europe; these first barrows were constructed by people of the Corded Ware culture and placed in alignments. This thesis is an interregional comparative study, to determine whether there is a pattern in the time-depths of the burial alignments of Trehuse-Sjørup-Dollerup in Denmark, Angelso-Emmerhout in The Netherlands and Lilla Beddinge in Sweden. The analysis is conducted by means of a literature study and the application of typochronologies. In recent research, the Corded Ware ‘culture’ is still seen as a widespread, unified social phenomenon that is the result of migration, but more emphasis is placed on the regional variability of this phenomenon. Regional variability is also what we see in the three case-studies; in fact, perhaps one may better speak of ‘local variability’, as each case-study reveals a remarkable variety even within one alignment. Even though there do seem to be interregionally shared traits, these are expressed in local practices. Despite the limitations of establishing a time-depth by means of typochronologies, all three alignments reveal a long use-life; even in the Bronze and Iron Ages, prehistoric people buried their dead here. Temporality seems to have been an important aspect of the ‘Corded Ware’ burial landscape

Collaborative mental health care : changing the landscape of mental health care?

In this thesis two major changes in the organization of mental health care delivery are explored. The first is collaborative mental health care in primary care, developed as an alternative way to treat common mental health disorders compared to the traditional referral and treatment practice. The collaborative care program followed the principles of stepped care. The first and least intensive treatment step was provided within the collaborative care program in the primary care setting. Treatment intensity was only stepped up through referral to specialized mental health care for patients who did not sufficiently respond to the first step. The traditional practice was direct referral and treatment within specialized care. In several studies we investigated effectiveness, short- and long-term efficiency, cost-effectiveness and whether the stepped care approach was appropriate for all patients instead of the matched care approach. The second change was the integration of eHealth in the collaborative care treatment model. In this study, implementation factors that could either inhibit or promote the uptake and utilization of blended collaborative care by mental health professionals and patients were assessed

Synthesis of Magnetic Lignin-Based Hollow Microspheres: A Highly Adsorptive and Reusable Adsorbent Derived from Renewable Resources

Lignin, a byproduct of the wood-pulping industry, is mostly treated as a noncommercialized waste product. Therefore, it is significant to study its potential for the conversion of this renewable and sustainable resource into high-valued chemicals and materials. In this study, a renewable lignin-based material with high performance in wastewater treatment has been explored on account of its satisfactory properties and being environmentally friendly. Herein, lignin hollow microspheres (LHM) were facilely prepared from esterified organosolv lignin with maleic anhydride (MA) via self-assembly in the mixed tetrahydrofuran–Fe₃O₄ nanoparticles aqueous media. Moreover, the magnetic lignin spheres (MLS) were also successfully fabricated by introducing Fe₃O₄ nanoparticles. The structural changes of esterified lignin polymers were identified and morphology and property of obtained LHM and MLS were characterized by means of TEM, SEM, VSM and FT-IR. In addition, the adsorption capacities of MLS for methylene blue and Rhodamine B from aqueous solutions were also comparatively investigated. It was observed from SEM and TEM images that the LHM from larch lignin exhibited uniform spherical and dense surface, but that from poplar lignin was not rigid enough to keep the perfect spherical shape and partially collapsed. The adsorption capacity results showed that the MLS from larch lignin exhibited better adsorption properties for methylene blue (31.23 mg/g) and Rhodamine B (17.62 mg/g) than that from poplar lignin (25.95 and 15.79 mg/g, respectively). Simultaneously, the adsorption kinetics and adsorption isotherm experiments indicated that the data were agreed well with the pseudo-second-order and Langmuir model, respectively. Moreover, after three cycles of desorption, the removal efficiencies of the MLS from larch and poplar lignin could still reach more than 98% and 96%, respectively. Therefore, the developed magnetic lignin-based hollow microspheres has shown a great potential as a low-cost, highly adsorptive and reusable adsorbent for the applications in the wastewater treatments

HiWATER: Dataset of vegetation LAI measured by LAI2000 in the middle reaches of the Heihe River Basin

HiWATER: Dataset of vegetation LAI measured by LAI2000 in the middle reaches of the Heihe River Basi

HiWATER: Dataset of airborne microwave radiometers (L bands) mission along the riverway of Heihe River in the middle reaches of the Heihe River Basin on 3 July, 2012

HiWATER: Dataset of airborne microwave radiometers (L bands) mission along the riverway of Heihe River in the middle reaches of the Heihe River Basin on 3 July, 201

HiWATER: Dataset of the Portable Soil Respiration in the middle reaches of the Heihe River Basin

HiWATER: Dataset of the Portable Soil Respiration in the middle reaches of the Heihe River Basi

HiWATER: Dataset of the spectral reflectance in the middle reaches of the Heihe River Basin

HiWATER: Dataset of the spectral reflectance in the middle reaches of the Heihe River Basi

HiWATER: The Multi-Scale Observation Experiment on Evapotranspiration over heterogeneous land surfaces (MUSOEXE) Dataset - flux observation matrix (an automatic weather station at Zhangye wetland station)

HiWATER: The Multi-Scale Observation Experiment on Evapotranspiration over heterogeneous land surfaces (MUSOEXE) Dataset - flux observation matrix (an automatic weather station at Zhangye wetland station