14 research outputs found
HFDMP raw data 2019.xlsx
Dataset for the manuscript entitled "Impact of Multi-Disciplinary Treatment Strategy on Systolic Heart Failure Outcome
Characteristics of subjects with stroke and matched controls.
Characteristics of subjects with stroke and matched controls.</p
Characteristics of stroke patients with herpes zoster.
Characteristics of stroke patients with herpes zoster.</p
Stroke associated with herpes zoster stratified by gender, age and by 1-year and 5-year follow-up period.
Stroke associated with herpes zoster stratified by gender, age and by 1-year and 5-year follow-up period.</p
Adjusted incidence rate ratios of herpes zoster during risk periods of 12 months following stroke.
Adjusted incidence rate ratios of herpes zoster during risk periods of 12 months following stroke.</p
Pictorial representation of the self-controlled case series study.
Pictorial representation of the self-controlled case series study.</p
Additional file 1 of Effectiveness and acceptability of noninvasive brain and nerve stimulation techniques for migraine prophylaxis: a network meta-analysis of randomized controlled trials
Additional file 1
Additional file 2 of Effectiveness and acceptability of noninvasive brain and nerve stimulation techniques for migraine prophylaxis: a network meta-analysis of randomized controlled trials
Additional file 2
Efficacy of pharmacologic treatment in tinnitus patients without specific or treatable origin: A network meta-analysis of randomised controlled trials
Background-
Although tinnitus has a prevalence between 20 and 42.8%, the currently recommended management for tinnitus, such as tinnitus support and psychologic therapies, are relatively time-consuming and expensive. Several new pharmacologic treatments designed for tinnitus patients without specific origin had been developed but their efficacy remains unclear.
Methods-
The current Network Meta-Analysis (NMA) of randomised controlled trials (RCTs) was conducted to evaluate the efficacy of different pharmacologic treatments for tinnitus management in tinnitus patients without specific or treatable origin (i.e. primary tinnitus). Databases were searched from inception to April 5th, 2021. All network meta-analytic procedures were conducted under the frequentist model. We calculated the effect size of outcomes with different rating scales with standardized mean difference. PROSPERO registration: CRD42020177742.
Findings-
Overall, 36 RCTs were included with 2,761 participants. The main results revealed that pharmacologic interventions with brain-acting effect (for example, amitriptyline, acamprosate, and gabapentin) and those with anti-inflammation/anti-oxidant effect (for example, intra-tympanic dexamethasone injection plus oral melatonin) were associated with superior improvement in tinnitus severity and response rate compared to placebo/control. Oral amitriptyline were associated with the highest improvement in tinnitus severity and the fourth highest response rate. None of the investigated interventions was associated with different changes in quality of life compared to placebo/control. All the investigated treatments were associated with similar drop-out rate to placebo/control.
Interpretation-
The current NMA suggests a potential role for treatments with brain-acting effect (for example, amitriptyline, acamprosate, and gabapentin) or anti-inflammation/anti-oxidant effect (for example, intra-tympanic dexamethasone injection plus oral melatonin) as the preferable effective treatments for tinnitus without specific or treatable origin
