59 research outputs found

    SELECTIVE IODINATION USING DIARYLIODONIUM SALTS

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    Aryl iodides have become widely recognized as versatile synthetic intermediates, owing to aromatic iodine’s excellent ability to participate in oxidative addition reactions. Iodoarenes readily undergo a variety of synthetic transformations including metal catalyzed cross-coupling reactions, diaryliodonium chemistry, formation of organometallics through reduction or metal-halogen exchange, as well as classical SN2 type chemistry. Because a wide array of transformations are available for aryl iodides, organic molecules containing this moiety often serve as vital precursors to highly desirable pharmaceuticals. This thesis describes a simple and selective two-step approach to the formation of aryl iodides. This method proceeds through an easily purified diaryliodonium salt intermediate, which is subsequently converted to the corresponding aryl iodide. This method is an effective and general process for the selective synthesis of a large variety of monoiodinated arenes that are difficult to access by other approaches. Advisor: Stephen G. DiMagn

    SELECTIVE IODINATION USING DIARYLIODONIUM SALTS

    Get PDF
    Aryl iodides have become widely recognized as versatile synthetic intermediates, owing to aromatic iodine’s excellent ability to participate in oxidative addition reactions. Iodoarenes readily undergo a variety of synthetic transformations including metal catalyzed cross-coupling reactions, diaryliodonium chemistry, formation of organometallics through reduction or metal-halogen exchange, as well as classical SN2 type chemistry. Because a wide array of transformations are available for aryl iodides, organic molecules containing this moiety often serve as vital precursors to highly desirable pharmaceuticals. This thesis describes a simple and selective two-step approach to the formation of aryl iodides. This method proceeds through an easily purified diaryliodonium salt intermediate, which is subsequently converted to the corresponding aryl iodide. This method is an effective and general process for the selective synthesis of a large variety of monoiodinated arenes that are difficult to access by other approaches. Advisor: Stephen G. DiMagn

    SELECTIVE IODINATION USING DIARYLIODONIUM SALTS

    Get PDF
    Aryl iodides have become widely recognized as versatile synthetic intermediates, owing to aromatic iodine’s excellent ability to participate in oxidative addition reactions. Iodoarenes readily undergo a variety of synthetic transformations including metal catalyzed cross-coupling reactions, diaryliodonium chemistry, formation of organometallics through reduction or metal-halogen exchange, as well as classical SN2 type chemistry. Because a wide array of transformations are available for aryl iodides, organic molecules containing this moiety often serve as vital precursors to highly desirable pharmaceuticals. This thesis describes a simple and selective two-step approach to the formation of aryl iodides. This method proceeds through an easily purified diaryliodonium salt intermediate, which is subsequently converted to the corresponding aryl iodide. This method is an effective and general process for the selective synthesis of a large variety of monoiodinated arenes that are difficult to access by other approaches. Advisor: Stephen G. DiMagn

    The James Webb Space Telescope Mission

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    Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4m4m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5m6.5m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

    Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8‚ÄČTeV\sqrt{s}=8\,\mathrm TeV{} with the ATLAS detector

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