Possible role of TGF-B pathways in schizophrenia

© 2016, University of Kragujevac, Faculty of Science. All Rights Reserved. The phenomenological uniqueness of each patient with schizophrenia is determined by complex symptomatology, particularly the overlapping of symptoms and their prominence in certain phases of this mental disorder. Establishing biological markers is an important step in the further objectivisation and quantification of schizophrenia. Identifying the cytokine profiles that precede a psychotic episode could direct the strategies for relapse prevention and be useful in predicting disease progression and treatment response. In the context of inflammation, TGF-β exerts potent anti-inflammatory and immunosuppressive functions by inhibiting pro-inflammatory cytokine synthesis, but it can also have pro-inflammatory functions through its stimulatory effects on inflammatory 17 cells. It has been shown that the T helper cell type-1 and type-17 responses are reduced and type-2 response is increased in patients with schizophrenia. Both data from the literature and our results also indicate the presence of an anti-inflammatory response through production of the TGF-β regulatory cytokine. A meta-analysis of plasma cytokine alterations suggested that TGF-β is the state marker for acute exacerbation of schizophrenia, and we showed that TGF-β can also be a valuable marker for psychosis. Hyperactivity of TGF-β signalling pathways in schizophrenia may be both a neuroprotective mechanism and a possible therapeutic target

Geoecological evaluation of local surroundings for the purposes of recreational tourism

The paper presents geoecological evaluation of the city of Loznica for the purposes of sports and recreational tourism based on quantitative method of diversity, V-Wert Method. Using the GIS tool by the quantitative method, the criteria of natural components (relief, forest, water surface and climate) are evaluated for the analyzed area. In the proposed method, the climate factor was supplemented by the analysis of the bioclimatic index Universal Thermal Climate Index (UTCI). When the evaluation was completed, the final results were obtained based on which the degrees of convenience of different parts of the analyzed area have been presented. Out of the total analyzed surface, which amounts to 705 km2 , favorable surfaces comprise 21 km2 (2.98%), and very favorable surfaces comprise 33 km2 , i.e. 4.68% of the territory. The largest area consists of conditionally favorable terrains — 333 km2 (47.23%). Since one of the basic strategic priorities of the City of Loznica is improvement and development of sports and recreational tourism, the aim of this analysis is to emphasize the potential of the mentioned area in terms of general suitability of the terrain for the development of this type of tourism

Acute muscle damage as a metabolic response to rapid weight loss in wrestlers

Study aim: Dietary and non-dietary weight loss methods are highly prevalent among combat sports athletes (CSA). Most CSA undergo rapid weight loss (RWL) usually a week before the competition to reduce their body mass and thus compete in the lowest weight category possible. The objective of the study was to distinguish the impact of high-intensity sport-specific training (HISST) combined with RWL (phase 1 - P1) on muscle damage markers as well as the effects of HISST alone (phase 2 - P2). Material and methods: This crossover study was carried out on 12 male wrestlers. It consisted of initial measurement (IM), high-intensity training combined with RWL of 5% (P1), and high-intensity training without RWL (P2). After each phase, muscle damage markers were measured, including myoglobin, aldolase, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Results: A substantial increase in analyzed biomarkers was evident in both phases (P1 and P2). However, higher levels of almost all biomarkers were observed in the phase that included RWL compared to the second phase, with a greater significance level. Conclusions: Our study revealed that 5% RWL combined with HISST impacted the assessed biomarkers to a greater extent than HISST alone, thus providing strong evidence of the influence of RWL on muscular damage in wrestlers. In order to minimize the adverse health-related effects induced by weight reduction, coaches and athletes should use caution when considering weight management methods

Redesigning diabetes care delivery in Serbia, using JA CHRODIS Recommendations and criteria

Introduction. Managing non-communicable diseases (NCDs) requires redesigning health care delivery to achieve better coordination of services at all levels of health care. The aim of this study was improving prevention and strengthening high quality of care for NCDs by using type 2 diabetes as a model disease. Methods. The mix method approach served to analyse the impact of the intervention processes. Source of information were routine health statistics, interviews and observation. Key Performance Indicators in defined Improvement Areas assisted in the quality of diabetes care assessment. Results and discussion. During the study the National Diabetes Centre (NDC) was established. The NDC experts organized numerous educational events, 316 physicians and nurses have participated. New electronic data base was implemented in 20 pilot Primary Health Care Centres (PHCCs) with 38,833 electronic diabetes records. Conclusions. The intervention led to establishment of the NDC, strengthening competences of health care professionals and to the renewal of the Diabetes Care Units in PHCCs included in the study

IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis

Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. Moreover, these parameters are potential prognostic and therapeutic markers. There is also accumulating evidence that these molecules play a role in neuroinflammation. Therefore, in this study we have investigated the serum level of Gal-3, IL-33 and soluble ST2 (sST2) in different stages of schizophrenia. Gal-3 levels were elevated in remission and lower in schizophrenia exacerbation in comparison with controls. Levels of IL-33 and sST2 are higher in schizophrenia exacerbation in comparison with controls and patients in remission. This initial analysis of new markers of neuroinflammation suggested their involvement in schizophrenia pathophysiology and/or cardiometabolic comorbidity

Aridity in the central and southern Pannonian basin

For the investigation of geographical, monthly, seasonal, and annual distributions of aridity and its annual trend in the region of the Central and Southern Pannonian Basin (CSPB), which includes the territories of Hungary and Vojvodina (Northern Serbia), the De Martonne Aridity Index (DMAI) was used. The DMAI was originally calculated from a total of 78 meteorological stations with the maximum available time series of climatological data in three cases: 1931–2017 for Hungary; 1949–2017 for Vojvodina; and 1949–2017 for Hungary and Vojvodina jointly. The Palmer Drought Severity Index (PDSI) was used to control the DMAI results. Temperature and precipitation trends were also investigated to understand their effects on the aridity trend. Three aridity types are distinguished on the annual level, five on the seasonal level, and four on the monthly level. The annual aridity had no trends in all three periods. It seems that aridity can be considered a more stable climate indicator of climate change than the temperature, at least in the CSPB. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Diagnostic Accuracy of Platelet Count and Platelet Indices in Noninvasive Assessment of Fibrosis in Nonalcoholic Fatty Liver Disease Patients

Objective. Keeping in mind the rising prevalence of nonalcoholic fatty liver disease (NAFLD) and the need to establish noninvasive tests for its detection, the aim of our study was to investigate whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) can predict the presence of liver fibrosis in this group of patients. Methods. In 98 patients with NAFLD and 60 healthy volunteers, complete blood counts with automated differential counts were performed and values of PC, PDW, MPV, and PCT were analyzed. Results. Patients with NAFLD had lower PC and higher MPV, PCT, and PDW compared to the controls (P < 0.05). When NAFLD group was stratified according to severity of liver fibrosis, there was a statistically significant difference in the average values of PDW and PC between the groups (P < 0.05). Conclusion. Patients with NAFLD have significantly higher values of PCT, PDW, and MPV when compared to the healthy controls. Further studies are needed to establish their potential use for prediction of the degree of liver steatosis and fibrosis in NAFLD patients

HERSUS Sharing Platform [Commendation at 44th Salon of Architecture]

The HERSUS Sharing Platform is a digital platform for researchers and students conceived as an educational tool and archive of resources around the topics of sustainability and heritage awareness in architecture and urban design. The platform has been designed and developed as a source of reference and inspiration to refer to when doing research in the fields that the HERSUS project aims to investigate. In the platform, links are created between apparently distant subjects, showing underlying narratives, connections and overlappings that bring contents together on different levels

Open House Seville - Exhibition

On 11 May 2023, in the framework of the USE HERSUS Event series, the USE OPEN HOUSE activity of the international HERSUS project took place. The Open House was organized in a form of exhibition which consists of three parts: (1) RESULTS OF THE HERSUS STUDENT WORKSHOPS (The brief preview of the Syllabuses and Student Results – research and designs), (2) AWARDED PROPOSALS OF THE HERSUS PRIZE ON MODERN HERITAGE (The awarded, finalist and shortlisted proposals for each of 4 categories – Edu- cation Students, Education Instructors, Practice, and Research), and (3) PRESENTATION OF HERSUS INTELLECTUAL OUTPUTS AND OTHER ACTIVITIES (Timeline of the HERSUS Intellectual outputs followed by presenta- tion of organized events and main achievements including HERSUS in numbers presentation) The exhibition was held at the LOBBY OF THE USE SCHOOL OF ARCHITECTURE ETSAS with participation and interest of local students, academics, and representatives from practice. Moreover, USE Team organized School tour for all HERSUS Partners and exhibition visitors in order to introduce the school profile and student life.HERSUS Consortium Vladan Djokić, Ana Radivojević, Ana Nikezić, Jelena Živković, Nataša Ćuković Ignjatović, Milica Milojević, Jelena Ristić Trajković, Aleksandra Milovanović, Aleksandra Djordjević, Mladen Pešić, Ana Zorić, Bojana Zeković, Tamara Popović, Nevena Lukić, Emanuela Sorbo, Enrico Anguillari, Sofia Tonello, Irene Sgarro,Maria Philokyprou, Aimilios Michael, Andreas Savvides, Panayiota Pyla, Odysseas Kontovourkis, Stavroula Thravalou, Maria Nodaraki, Theodora Hadjipetrou, Konstantinos Sakantamis, Alkmini Paka, Kleoniki Axarli, Maria Doussi, Angeliki Chatzidimitriou, Sofoklis Kotsopoulos, Mar Loren-Méndez, José Peral López, Enrique Larive, Julia Rey, Marta García de Casasola Gómez, María Carrascal, Daniel Pinzón-Ayala, María Álvarez de los Corrales, Roberto Alonso-Jiménez. Учесници: Архитектонски факултет, Универзитет у Београду (Србија), IUAV University of Venice (Италија), University of Cyprus (Кипар), Aristotle University of Thessaloniki (Грчка), и University of Seville – UNESCO Chair on Built Urban Heritage CREhAR in the digital era (Шпанија)

Hersus пројекат и дигитална платформа дељења (2020–2023) [65. Међународни сајам технике и техничких достигнућа]

HERSUS je Erasmus + стратешко партнерство које окупља пет универзитета из Србије, Италије, Кипра, Грчке и Шпаније који заједно раде на дизајну и развоју иновативних интелектуалних исхода и изградњи дигиталне платформу дељења. HERSUS платформа дељења је дигитална платформа за истраживаче и студенте замишљена као архива ресурса о темама одрживости и свести о наслеђу у архитектури и урбанизму. У платформи се стварају везе између наизглед удаљених тема, показујући основне наративе, везе и преклапања која се налазе на различитим просторним и друштвеним нивоима.Учесници: Архитектонски факултет, Универзитет у Београду (Србија), IUAV University of Venice (Италија), University of Cyprus (Кипар), Aristotle University of Thessaloniki (Грчка), и University of Seville – UNESCO Chair on Built Urban Heritage CREhAR in the digital era (Шпанија). HERSUS Consortium Vladan Djokić, Ana Radivojević, Ana Nikezić, Jelena Živković, Nataša Ćuković Ignjatović, Milica Milojević, Jelena Ristić Trajković, Aleksandra Milovanović, Aleksandra Djordjević, Mladen Pešić, Ana Zorić, Bojana Zeković, Tamara Popović, Nevena Lukić, Emanuela Sorbo, Enrico Anguillari, Sofia Tonello, Irene Sgarro,Maria Philokyprou, Aimilios Michael, Andreas Savvides, Panayiota Pyla, Odysseas Kontovourkis, Stavroula Thravalou, Maria Nodaraki, Theodora Hadjipetrou, Konstantinos Sakantamis, Alkmini Paka, Kleoniki Axarli, Maria Doussi, Angeliki Chatzidimitriou, Sofoklis Kotsopoulos, Mar Loren-Méndez, José Peral López, Enrique Larive, Julia Rey, Marta García de Casasola Gómez, María Carrascal, Daniel Pinzón-Ayala, María Álvarez de los Corrales, Roberto Alonso-Jiménez (2022)