2 research outputs found

    I Know What You Did on Wattpad: Understanding the Adolescent Desire to Write Self-Insert Fanfiction

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    Fanfiction has always been popular, but through the expansion of the internet, it can be viewed as well as published anywhere at any time. Fanfiction written by young female authors tends to follow similar themes and tropes across the age group, and often, are self-insert fanfictions. Self-insert is a term to describe a character who is the author’s surrogate character. In my research, I wanted to determine what the appeal of writing these types of characters would be. By extensively looking at many research papers and published fanfictions, I have determined that the main appeal for young women to write self-insert fanfiction is how the creative media gives them the ability for author expression, escapism, and experimentation throughout different stories. While certain problematic aspects are present in adolescent written fanfiction, such as sexually explicit content, they are not something that can be linked directly to fanfiction as a cause for the controversial aspects because they can also be seen in different online communities outside of fanfiction

    Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

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    Genome-wide association (GWA) studies have identified 19 independent common risk loci for endometriosis. Most of the GWA variants are non-coding and the genes responsible for the association signals have not been identified. Herein, we aimed to assess the potential role of protein-modifying variants in endometriosis using exome-array genotyping in 7164 cases and 21005 controls, and a replication set of 1840 cases and 129016 controls of European ancestry. Results in the discovery sample identified significant evidence for association with coding variants in single-variant (rs1801232-CUBN) and gene-level (CIITA and PARP4) meta-analyses, but these did not survive replication. In the combined analysis, there was genome-wide significant evidence for rs13394619 (P = 2.3 × 10(-9)) in GREB1 at 2p25.1 - a locus previously identified in a GWA meta-analysis of European and Japanese samples. Despite sufficient power, our results did not identify any protein-modifying variants (MAF > 0.01) with moderate or large effect sizes in endometriosis, although these variants may exist in non-European populations or in high-risk families. The results suggest continued discovery efforts should focus on genotyping large numbers of surgically-confirmed endometriosis cases and controls, and/or sequencing high-risk families to identify novel rare variants to provide greater insights into the molecular pathogenesis of the disease
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