Commerce Numérique: traffic signals for crossroads between cultures.

Commerce is a French literary journal - founded by Princess Margherita Caetani - which relied on the collaboration of three prestigious writers: Paul Valéry, Léon-Paul Fargue, and Valéry Larbaud. The journal is composed of twenty-nine volumes published between 1924 and 1932. Each volume includes different literary material like poems and novels, written by both well- known and unknown writers, who also translated important authors like Joyce, T.S. Eliot, Pirandello, Ungaretti, Saint-John Perse, Rilke, and Hofmannsthal. Considering the historical, literary, and cultural importance of the journal Commerce, our project “Commerce numérique” aims to digitize and to make the journal contents freely available online to both the general public and the research community. This article describes the way in which the journal was encoded. Particular importance is also given to the encoding of poems present in Commerce. Some poems are in the original language and are accompanied by their French translation, other poems are in the French-translated form without the original text. In order to fully and accurately express the phenomena and their structures, we adopted some aspects of the TEI framework that will be explained in detail. The French translation of a Moroccan Arabic poem from the 13th century is also considered. The original Arabic poem is interesting because it presents aspects of both the Moroccan dialect and the oral text. The study and the encoding of the Arabic poem in parallel to its translation highlight some important structural differences between Arabic poetry and Western poetry

Detection and Investigation of Extracellular Vesicles in Serum and Urine Supernatant of Prostate Cancer Patients

none13no: Prostate Cancer (PCa) is one of the most frequently identified urological cancers. PCa patients are often over-diagnosed due to still not highly specific diagnostic methods. The need for more accurate diagnostic tools to prevent overestimated diagnosis and unnecessary treatment of patients with non-malignant conditions is clear, and new markers and methods are strongly desirable. Extracellular vesicles (EVs) hold great promises as liquid biopsy-based markers. Despite the biological and technical issues present in their detection and study, these particles can be found highly abundantly in the biofluid and encompass a wealth of macromolecules that have been reported to be related to many physiological and pathological processes, including cancer onset, metastasis spreading, and treatment resistance. The present study aims to perform a technical feasibility study to develop a new workflow for investigating EVs from several biological sources. Serum and urinary supernatant EVs of PCa, benign prostatic hyperplasia (BPH) patients, and healthy donors were isolated and investigated by a fast, easily performable, and cost-effective cytofluorimetric approach for a multiplex detection of 37 EV-antigens. We also observed significant alterations in serum and urinary supernatant EVs potentially related to BPH and PCa, suggesting a potential clinical application of this workflow.openSalvi, Samanta; Bandini, Erika; Carloni, Silvia; Casadio, Valentina; Battistelli, Michela; Salucci, Sara; Erani, Ilaria; Scarpi, Emanuela; Gunelli, Roberta; Cicchetti, Giacomo; Guescini, Michele; Bonafè, Massimiliano; Fabbri, FrancescoSalvi, Samanta; Bandini, Erika; Carloni, Silvia; Casadio, Valentina; Battistelli, Michela; Salucci, Sara; Erani, Ilaria; Scarpi, Emanuela; Gunelli, Roberta; Cicchetti, Giacomo; Guescini, Michele; Bonafè, Massimiliano; Fabbri, Francesc

Timing of initiation of oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation comparing posterior and anterior circulation strokes

Background: The aim of this study in patients with acute posterior ischemic stroke (PS) and atrial fibrillation (AF) were to evaluate the risks of recurrent ischemic event and severe bleeding and these risks in relation with oral anticoagulant therapy (OAT) and its timing. Methods: Patients with PS were prospectively included; the outcome events of these patients were compared with those of patients with anterior stroke (AS) which were taken from previous registries. The primary outcome was the composite of: stroke recurrence, TIA, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding occurring within 90 days from acute stroke. Results: A total of 2,470 patients were available for the analysis: 473 (19.1%) with PS and 1,997 (80.9%) AS. Over 90 days, 213 (8.6%) primary outcome events were recorded: 175 (8.7%) in patients with AS and 38 (8.0%) in those with PS. In patients who initiated OAT within 2 days, the primary outcome occurred in 5 out of 95 patients (5.3%) with PS compared to 21 out of 373 patients (4.3%) with AS (OR 1.07; 95% CI 0.39-2.94). In patients who initiated OAT between days 3 and 7, the primary outcome occurred in 3 out of 103 patients (2.9%) with PS compared to 26 out of 490 patients (5.3%) with AS (OR 0.54; 95% CI 0.16-1.80). Conclusions: Patients with posterior or anterior stroke and AF appear to have similar risks of ischemic or hemorrhagic events at 90 days with no difference concerning the timing of initiation of OAT

The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Abstract Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF. Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding). Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77). Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability

L'acqua nel panorama economico e politico internazionale

L'acqua è un risorsa vitale e proprio per questa sua importanza ho deciso di studiare e capire il ruolo delle risorse idriche nel panorama economico e politico internazionale. Nel primo capitolo cerco di fare un quadro della distribuzione dell'acqua, della situazione attuale dello sfruttamento dell'acqua e del ruolo centrale che ricopre proprio quest'anno negli appuntamenti internazionali. Nel secondo capitolo ripercorro le tappe principali che hanno portato al riconoscimento del diritto all'acqua e parlo della minaccia che costituisce il processo di privatizzazione per l'accesso all'acqua. Nel terzo capitolo riporto l'esperienza del Forum Alternativo Mondiale sull'acqua di quest'anno, quello dei movimenti e delle associazioni da una parte e del Forum Mondiale "ufficiale" sull'acqua, quello dei governi e delle multinazionali, dall'altra

The effects of gestures in second language acquisition: a pilot study about early second language acquisition and vocabulary memorization in an Italian-English bilingual preschool.

This dissertation examines the effects of gesture on early vocabulary memorization in teaching English as a Second language to young learners in a bilingual environment that uses a natural and an affective-humanistic approach together with multimodality as the main strategy. 9 children (mean age 4) took part in this pilot study in which 24 target words were presented in two different modalities: Verbal Training (VT) and Gestural Training (GT). Kids were exposed to those new words for 7 weeks and then their active and passive language skills were tested with two different tests of evaluation: Expressive One-Word-Picture-Vocabulary Test and Sequenced Inventory of Communicative Development Test. Results show that gestures significantly influence the memorization of the target words in both expressive and receptive language, as well as their communicative abilities and strategies. This finding can be considered extremely significant for the second language teaching community. In fact, gestures could be considered a tool for both teachers and pupils in early second language teaching

Evocare l'antico come metodo di progetto: La valorizzazione del sito archeologico della città romana di Suasa

Il progetto per la città romana di Suasa, prevede la realizzazione di edifici nuovi a supporto del nuovo parco, tra cui i due visitor center, un edificio nell'area del Tappatino e una nuova copertura e funzionalizzazione per la Domus dei Coiedii

EpiLexO

EpiLexO is a user friendly web application for the creation and editing of an integrated system of language resources for ancient fragmentary languages centered on the lexicon, in compliance with current digital humanities and Linked Open Data principles. EpiLexo allows for the editing of lexica with all relevant cross-references: for their linking to their testimonies, as well as to bibliographic information and other (external) resources and common vocabularies. This front-end application rests on a Service-Oriented Architecture with two main back-end components, the LexO-server (\handle) and the CASH-server (1github), which manage lexica and textual documents respectively via Rest-ful APIs web-services, plus additional services for the management of other aspects such as access and authentication, XML rendering, etc. All code is available on https://github.com/DigItAnt/ The application has been developed in the context of a project on the languages of fragmentary attestation of ancient Italy, but can be applied to other similar contexts