Octakis(tetracarbonylcobaltio)octasilsesquioxane: Synthesis, Structure, and Reactivity

The reaction of octacarbonyldicobalt with octahydridosilsesquioxane (4:1 stoichiometry) in hexane leads to octakis(tetracarbonylcobaltio)octasilsesquioxane (1), the first octasilsesquioxane in which eight metals are directly bound to the silicon atoms of the siloxane cage. The product has been characterized by 29Si CP-MAS NMR, IR, and Raman spectroscopy as well as elemental analysis and MALDI TOF spectrometry. The molecular structure of 1 has been determined by single-crystal X-ray diffraction. In combination with triphenylphosphine, 1 shows catalytic activity in the hydroformylation of 1-hexene

MOESM1 of Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers

Additional file 1. Force clamp experiments of dsDNA molecule with 3 µM MTX at different forces. dsDNA was incubated with 3 µM Mitoxantrone for 2 h in the relaxed state. The forces 0.1, 1, 5 and 10 pN were successively applied to the bead so that the DNA molecule was stretched. After a delay of 10 s, which was as well included in the force-extension measurements, the DNA extensions were recorded as a function of time. The constant DNA lengths in a large time scale (10 min) indicate that the mitoxantrone already equilibrated its association to the DNA before the force measurements were taken and displayed a fast equilibrium assembly. Here, d/L0 is the normalized end-to-end distance of the DNA molecule and L0 represents the DNA contour length in the absence of mitoxantrone