Conception de systèmes polyculture-élevage en Centre Ardenne : défis et enjeux

Présentation des essais en polycultures élevage au Centre wallon de Recherches Agronomique

MoMEMta, a modular toolkit for the Matrix Element Method at the LHC

The Matrix Element Method has proven to be a powerful method to optimally exploit the information available in detector data. Its widespread use is nevertheless impeded by its complexity and the associated computing time. MoMEMta, a C++ software package to compute the integrals at the core of the method, provides a versatile implementation of the Matrix Element Method to both the theory and experiment communities. Its modular structure covers the needs of experimental analysis workflows at the LHC without compromising ease of use on simpler and smaller simulated samples used for phenomenological studies. With respect to existing tools, MoMEMta improves on usability and flexibility. In this paper, we present version 1.0 of MoMEMta, together with examples illustrating the wide range of applications at the LHC accessible for the first time with a single tool.Comment: 18 pages, 3 figures; post peer revie

Net productivity, a new metric to evaluate the contribution to food security of livestock systems: the case of specialised dairy farms

peer reviewedThe increasing human population and demand for animal food products raise the issue of impacts of animal systems on food security caused by their use of human-edible feed and/or tillable land. The utility of replacing animal systems with potential food-crop systems needs to be assessed but is associated with many uncertainties. Some metrics analyse the contribution of current animal systems to food security, especially the dimension of food availability. These methods address feed conversion efficiency (i.e. total (‘gross’) or human-edible (‘net’)) or the efficiency of agricultural land use (i.e. total, permanent grassland, and tillable land) but never both simultaneously. The purpose of this study was to develop a new metric—‘net productivity’—to represent the performances of current animal systems more accurately by considering both the use of human-edible feed and agricultural land. Through a protein assessment, we analysed the ability of the existing and the new metrics to assess the performances of 111 dairy farms in Wallonia (Belgium). We found that net productivity was positively correlated with both metrics of feed conversion efficiency and negatively correlated with the three metrics of land use. To analyse the influence of farm characteristics, we grouped the farms into four clusters using k-means clustering based on these metrics of contribution to food security and then performed redundancy analysis to select the most influential farm characteristics aiming to highlight contrasted farm strategies. The highest net productivity was reached by an ‘intensive and net efficient’ farm strategy, which had intensive grass-based management, high milk production per cow, appropriate use of concentrates, and well-managed dairy followers (i.e. replacement heifers and calves). The newly developed metric of net productivity can be useful to quantify the contribution of dairy systems to food security by considering both the use of human-edible protein and agricultural land simultaneously

Expression Analysis of PAC1-R and PACAP Genes in Zebrafish Embryos

This study describes the expression of the pituitary adenylate cyclase-activating polypeptide (PACAP1 and PACAP2) and PAC1 receptor genes (PAC1a-R and PAC1b-R) in the brain of zebrafish (Danio rerio) during development. In situ hybridization of the 24- and 48-hpf embryos revealed that PACAP genes were expressed in the telencephalon, the diencephalon, the rhombencephalon, and the neurons in the dorsal part of the spinal cord. PACAP2 mRNA appears to be the most abundant form during brain development. The two PAC1-R subtypes showed a similar expression pattern: mRNAs were detected in the forebrain, the thalamus, and the rhombencephalon. However, in the tectum, only PAC1b-R gene was detected. These results suggest that, in fish, PACAP may play a role in brain development

Evaluation of the contribution of 16 European beef production systems to food security

peer-reviewedContext Livestock production, and more particularly ruminants, is criticized for its low conversion efficiency of natural resources into edible food. Objective The objectives of this paper are to propose an evaluation of the contribution to food security of different European cattle farms through three criteria: 1) food production assessed by the amount of human-edible protein (HEP) and energy (HEE) produced at farm level, 2) feed-food competition at the beef production scale estimated in terms of net human-edible protein and energy and in terms of land used, and 3) food affordability assessed by the production cost of meat, protein and energy. Methods The analysis is based on 16 representative beef production systems in France, Belgium, Ireland, Italy and Germany and covers cow-calf systems, finishing systems, dairy and mixed dairy- finishing systems, with or without cash crops. Results and conclusions The results show that, at the farm level, systems producing both beef and milk or cereals have higher HEP and HEE production per hectare (up to 370 kg of HEP and 60,000 106J.ha−1) than specialized beef systems (up to 50 kg of HEP and 1600 106J.ha−1) and have lower production costs (approximately €6 kg−1 of HEP in mixed beef system and €29 kg−1 of HEP in a specialized cow-calf-fattener system). Beef systems are almost all HEE net consumers. Results are more variable concerning net HEP efficiency. The cow-calf enterprises are mostly net producers of HEP but, in order to produce human edible meat, these systems need to be combined with finishing systems that are mostly net consumers of HEP. In most cases, cow-calf-finishing systems are net consumers of HEP (between 0.6 and 0.7) but grass-based systems using very little concentrates or systems using co-products not edible by humans are net HEP producers. The grass-based systems use more land area per kilogram of carcass but a major part of this area is non-tilled land, thus these systems are not in direct competition with human food production. The lowest meat production costs are the finishing systems producing the most live weight per livestock unit (LU) per year and dairy systems in lowland which share the costs between milk and meat. Significance Although most of HEE and HEP efficient farms typically have higher meat production costs, some grassland based systems stand out positively for all indicators. These results pave the way for improvements of the contribution of beef production systems to food security. Graphical abstract Net Human Edible Protein and Energy Efficiencies of meat production (M_HEP_eff and M_HEE_eff)

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

Mitogen-activated protein kinase (MAPK) pathway antagonists induce profound clinical responses in advanced cutaneous melanoma, but complete remissions are frustrated by the development of acquired resistance. Before resistance emerges, adaptive responses establish a mutation-independent drug tolerance. Antagonizing these adaptive responses could improve drug effects, thereby thwarting the emergence of acquired resistance. In this study, we reveal that inflammatory niches consisting of tumor-associated macrophages and fibroblasts contribute to treatment tolerance through a cytokine-signaling network that involves macrophage-derived IL-1β and fibroblast-derived CXCR2 ligands. Fibroblasts require IL-1β to produce CXCR2 ligands, and loss of host IL-1R signaling in vivo reduces melanoma growth. In tumors from patients on treatment, signaling from inflammatory niches is amplified in the presence of MAPK inhibitors. Signaling from inflammatory niches counteracts combined BRAF/MEK (MAPK/extracellular signal–regulated kinase kinase) inhibitor treatment, and consequently, inhibiting IL-1R or CXCR2 signaling in vivo enhanced the efficacy of MAPK inhibitors. We conclude that melanoma inflammatory niches adapt to and confer drug tolerance toward BRAF and MEK inhibitors early during treatmen

2021 roadmap for sodium-ion batteries

Abstract: Increasing concerns regarding the sustainability of lithium sources, due to their limited availability and consequent expected price increase, have raised awareness of the importance of developing alternative energy-storage candidates that can sustain the ever-growing energy demand. Furthermore, limitations on the availability of the transition metals used in the manufacturing of cathode materials, together with questionable mining practices, are driving development towards more sustainable elements. Given the uniformly high abundance and cost-effectiveness of sodium, as well as its very suitable redox potential (close to that of lithium), sodium-ion battery technology offers tremendous potential to be a counterpart to lithium-ion batteries (LIBs) in different application scenarios, such as stationary energy storage and low-cost vehicles. This potential is reflected by the major investments that are being made by industry in a wide variety of markets and in diverse material combinations. Despite the associated advantages of being a drop-in replacement for LIBs, there are remarkable differences in the physicochemical properties between sodium and lithium that give rise to different behaviours, for example, different coordination preferences in compounds, desolvation energies, or solubility of the solid–electrolyte interphase inorganic salt components. This demands a more detailed study of the underlying physical and chemical processes occurring in sodium-ion batteries and allows great scope for groundbreaking advances in the field, from lab-scale to scale-up. This roadmap provides an extensive review by experts in academia and industry of the current state of the art in 2021 and the different research directions and strategies currently underway to improve the performance of sodium-ion batteries. The aim is to provide an opinion with respect to the current challenges and opportunities, from the fundamental properties to the practical applications of this technology