Exploring Bs→Ds(∗)±K∓B_s \to D_s^{(*)\pm} K^\mp Decays in the Presence of a Sizable Width Difference ΔΓs\Delta\Gamma_s

The $B_s \to D_s^{(*)\pm} K^\mp$ decays allow a theoretically clean determination of $\phi_s+\gamma$, where $\phi_s$ is the $B^0_s$-$\bar B^0_s$ mixing phase and $\gamma$ the usual angle of the unitarity triangle. A sizable $B_s$ decay width difference $\Delta\Gamma_s$ was recently established, which leads to subtleties in analyses of the $B_s \to D_s^{(*)\pm} K^\mp$ branching ratios but also offers new "untagged" observables, which do not require a distinction between initially present $B^0_s$ or $\bar B^0_s$ mesons. We clarify these effects and address recent measurements of the ratio of the $B_s\to D_s^\pm K^\mp$, $B_s\to D_s^\pm\pi^\mp$ branching ratios. In anticipation of future LHCb analyses, we apply the SU(3) flavour symmetry of strong interactions to convert the $B$-factory data for $B_d\to D^{(*)\pm}\pi^\mp$, $B_d\to D_s^{\pm}\pi^\mp$ decays into predictions of the $B_s \to D_s^{(*)\pm} K^\mp$ observables, and discuss strategies for the extraction of $\phi_s+\gamma$, with a special focus on untagged observables and the resolution of discrete ambiguities. Using our theoretical predictions as a guideline, we make simulations to estimate experimental sensitivities, and extrapolate to the end of the planned LHCb upgrade. We find that the interplay between the untagged observables, which are accessible thanks to the sizable $\Delta\Gamma_s$, and the mixing-induced CP asymmetries, which require tagging, will play the key role for the experimental determination of $\phi_s+\gamma$.Comment: 21 pages, 7 figures, matches published versio

Terrace Standard, March, 01, 1995

Observation has lead to a conclusion that the physics analysis jobs run by LHCb physicists on a local computing farm (i.e. non-grid) require more efficient access to the data which resides on the Grid. Our experiments have shown that the I/O bound nature of the analysis jobs in combination with the latency due to the remote access protocols (e.g. rfio, dcap) cause a low CPU efficiency of these jobs. In addition to causing a low CPU efficiency, the remote access protocols give rise to high overhead (in terms of amount of data transferred). This paper gives an overview of the concept of pre-fetching and caching of input files in the proximity of the processing resources, which is exploited to cope with the I/O bound analysis jobs. The files are copied from Grid storage elements (using GridFTP), while concurrently performing computations, inspired from a similar idea used in the ATLAS experiment. The results illustrate that this file staging approach is relatively insensitive to the original location of the data, and a significant improvement can be achieved in terms of the CPU efficiency of an analysis job. Dealing with scalability of such a solution on the Grid environment is discussed briefly

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary and acquired resistance to SMO inhibitors limit their efficacy. An understanding of underlying molecular mechanisms of resistance to therapy is warranted to bridge this unmet need. Here, we make use of genome-wide CRISPR-Cas9 knockout screens in murine SMB21 and human DAOY cells, in order to unravel genetic dependencies and drug-related genetic interactors that could serve as alternative therapeutic targets for SHH-MB. Our screens reinforce SMB21 cells as a faithful model system for SHH-MB, as opposed to DAOY cells, and identify members of the epigenetic machinery including DNA methyltransferase 1 (DNMT1) as druggable targets in SHH-dependent tumors. We show that Dnmt1 plays a crucial role in normal murine cerebellar development and is required for SHH-MB growth in vivo. Additionally, DNMT1 pharmacological inhibition alone and in combination with SMO inhibition effectively inhibits tumor growth in murine and human SHH-MB cell models and prolongs survival of SHH-MB mouse models by inhibiting SHH signaling output downstream of SMO. In conclusion, our data highlight the potential of inhibiting epigenetic regulators as a novel therapeutic avenue in SMO-inhibitor sensitive as well as resistant SHH-MBs

Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era

The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034 cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier

LHCb upgrade software and computing : technical design report

This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages