Additional file 3: of Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

Figure S3. Total IgG antibodies in serum of recipient mice. (JPG 134 kb

Additional file 2 of Identification of potential susceptibility genes in patients with primary Sjögren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing

Additional file 2: Supplementary Figure 1. Variants found in FLG, BCR, GIGYF2, ITK, and SLC26A4 verified by Sanger sequencing

Additional file 1 of Identification of potential susceptibility genes in patients with primary Sjögren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing

Additional file 1: Supplementary Table 1. Susceptibility genes of primary Sjögren’s syndrome-associated pulmonary arterial hypertension identified by whole genome sequencing

Additional file 2: of Prognostic profile of systemic sclerosis: analysis of the clinical EUSTAR cohort in China

Clinical manifestation and survival rates published by different countries since 2008. (DOCX 19 kb

Additional file 1: of Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

Table S1. Alpha diversity indices of donor mice and recipient mice. (DOCX 15 kb

Additional file 1: of Prognostic profile of systemic sclerosis: analysis of the clinical EUSTAR cohort in China

Figure S1. Survival analysis based on respiratory symptoms. Figure S2. Survival analysis based on organ involvement. (DOCX 550 kb

Additional file 2: of Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

Figure S1. Gut microbiota composition in donor mice and recipient mice. Figure S2. PCA of the microbiota in donor mice and recipient mice. (PDF 295 kb

The 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis Could Classify Systemic Sclerosis Patients at Earlier Stage: Data from a Chinese EUSTAR Center

<div><p>Objectives</p><p>To evaluate the performance of the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in clinical practice in a Chinese patient cohort, and to compare outcomes with the 1980 ACR criteria.</p><p>Methods</p><p>Patients clinically diagnosed with SSc between September 2013 and May 2015 were prospectively recruited from the EUSTAR database of the Peking Union Medical College Hospital. Diagnosis of SSc was based on the evaluation of three experienced rheumatologists. Patients diagnosed with other connective tissue diseases were recruited as disease controls. The 1980 ACR and 2013 ACR/EULAR criteria were applied to the cohort, and patients who fulfilled the criteria were classified as definite SSc patients. Sensitivity and specificity were analyzed for the 2013 and 1980 criteria.</p><p>Results</p><p>A total of 143 SSc patients and 87 patients with other connective diseases were recruited. 41 (28.7%) and 102 (71.3%) cases were diffuse cutaneous SSc and limited cutaneous SSc, respectively. Although the sensitivity of the 2013 criteria (94.4%) exceeded the 1980 criteria (72.7%) (P<0.001), the 1980 and 2013 criteria sets showed no significant difference in specificity (97.7% and 93.1%, respectively, P = 0.278). The sensitivity of the 2013 criteria was significantly higher than the 1980 criteria in some SSc subgroups (e.g., lcSSc, abnormal pattern of nailfold videocapillaroscopy [NVC] and presence of Raynaud’s phenomenon [RP]) compared to others.</p><p>Conclusions</p><p>Relative to the 1980 ACR criteria, in Chinese SSc patients the new 2013 ACR/EULAR criteria had similar specificity and higher sensitivity, especially for patients with mild skin thickening or prominent microvascular diseases.</p></div

Additional file 1 of Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

Additional file 1. Serum samples from 15 patients with SSc and five HCs

Sensitivity and specificity of 1980 ACR and 2013 ACR/EULAR criteria in different countries.

<p>Sensitivity and specificity of 1980 ACR and 2013 ACR/EULAR criteria in different countries.</p