Multivairate logistic regression model for factors related to acute kidney injury.

<p>Multivairate logistic regression model for factors related to acute kidney injury.</p

Risk Factors for Development of Acute Kidney Injury in Patients with Urinary Tract Infection

<div><p>Acute kidney injury (AKI) is associated with high morbidity and mortality. Urinary tract infection (UTI) may be associated with sepsis or septic shock, and cause sudden deterioration of renal function. This study investigated the clinical characteristics and change of renal function to identify the risk factors for development of AKI in UTI patients. This retrospective study was conducted in a tertiary referral center. From January 2006 to January 2013, a total of 790 UTI patients necessitating hospital admission were included for final analysis. Their demographic and clinical characteristics and comorbidities were collected and compared. Multivariate logistic regression analysis was performed to evaluate the risk factors for AKI in UTI patients. There were 97 (12.3%) patients developing AKI during hospitalization. Multivariate logistic regression analysis showed that patients with older age (OR 1.02, 95% CI 1.00–1.04, <i>P</i> = 0.04), diabetes mellitus (DM) (OR 2.23, 95% CI 1.35–3.68, <i>P</i> = 0002), upper UTI (OR 2.63, 95% CI 1.53–4.56, <i>P</i> = 0001), afebrile during hospitalization (OR 1.71, 95% CI 1.04–2.83, <i>P</i> = 0036) and lower baseline eGFR [baseline eGFR 45–59 mL/min/1.73 m² (OR 2.12, 95% CI 1.12–4.04, <i>P</i> = 0.022), baseline eGFR 30-44 mL/min/1.73 m² (OR 4.44, 95% CI 2.30–8.60 <i>P</i> < 0.001) baseline eGFR < 30 mL/min/1.73 m² (OR 4.72, 95% CI 2.13–10.45, <i>P</i> <0.001), respectively] were associated with increased risk for development of AKI. were associated with increased risk for development of AKI. Physicians should pay attention to UTI patients at risk of AKI (advancing age, DM, upper UTI, afebrile, and impaired baseline renal function).</p></div

Multivariate analysis of associations between eGFR and acute kidney injury.

<p>^aN = 790. ^bMultivariate model adjusted for gender, diabetes mellitus, hypertension, congestive heart failure, coronary artery disease, stroke, malignancy, indwelling foley catheter, afebrile, upper UTI, septic shock, baseline eGFR group.</p

Rectangle below: patients included for analyses.

<p>Rectangle below: patients included for analyses.</p

Additional file 1 of Genetic underpinnings explored: OPA1 deletion and complex phenotypes on chromosome 3q29

Supplementary Material

Additional file 2 of Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa

Additional file 2: Supplementary Fig. 2. Sanger sequencing of the PCDH15 gene. The sequence trace shows the PCDH15 variant, which is consistent with whole exome sequencing (WES) test results

Additional file 1 of Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa

Additional file 1: Supplementary Fig. 1. Full-field electroretinography (ffERG) at presentation shows extinguished rod response, combined rod-cone response, cone response and 30 Hz flicker response in both eyes