How do Patients with Chronic Diseases Make Usage Decisions Regarding Mobile Health Monitoring Services?

The increasing population of patients with chronic diseases generates great challenge of chronic disease management. The occurrence of mobile health monitoring service is beneficial to chronic disease prevention and health promotion. The objective of this study is to investigate how the patients with chronic diseases make usage decisions on mobile health monitoring service. A survey comprising 261 subjects were conducted to validate the research model and proposed hypotheses. The results revealed that health severity positively influences mobile health monitoring service use intention, while negative health emotions do not. Health uncertainty avoidance strengthens the effect of health severity but weakens the effect of negative health emotions on mobile health monitoring service use intention. Limitations and implications for research and practice are discussed

A Personalization-Privacy Paradox in Usage of Mobile Health Services: A Game Theoretic Perspective

As health information privacy concern of the public raises, people are hesitant on disclosure of their private health information for personalized health services from using mobile health. The tension between personalization and privacy hinders users’ adoption of mobile health services. In this study, we draw on game theory to explain the personalization-privacy paradox in the usage of mobile health services. The results show that: (1) In a one-shot game, the strategy set of mobile health marketers and users will be contrary to their original motivations. (2) In a repeated game, collecting users’ private health information in a friendly way and disclosing private health information will be dominant strategies for both players. Managers need to pay attention to these scenarios in promoting usage of mobile health services

Examining the Role of Technology Anxiety and Health Anxiety on Elderly Users’ Continuance Intention for Mobile Health Services Use

Mobile health (mHealth) is considered to be an important means of releasing the aging population problem. The efficiency of mHealth service can be increased by incorporating more elderly users and guaranteeing their continued use. However, limited attention has been directed toward investigating elderly users’ continuance intention for mHealth service use. Drawing upon the trust theory, we investigated elderly users’ characteristics, i.e. health anxiety and technology anxiety, to explain continuance intention. Survey data were collected comprising 261 valid responses to validate the research model and hypotheses. The results revealed that both cognitive and affective trust enhance continuance intention of mHealth services use. Health anxiety strengthens the effect of cognitive trust, but weakens the effect of affective trust, on the continuance intention. Furthermore, technology anxiety strengthens the effect of affective trust, but not that of cognitive trust, on the continuance intention. The limitations of our study and the theoretical and practical implications are discussed

Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease

Background: Gene COPINE III may be related to a phosphoprotein with intrinsic kinase activity and  belongs to an unconventional kinase family. The CPNE3 gene may be used as a biomarker for assess- ment of occurrence and prognosis of various tumors. Methods: Peripheral blood was collected from 87 stable coronary artery disease (CAD) patients and 91 acute myocardial infarction (AMI) patients. Real-time quantitative polymerase chain reaction test and the western blot method were adopted to measure expression quantity of CPNE3 gene at the mRNA level and the protein level.  Results: The expression of the CPNE3 gene in peripheral blood of AMI patients was significantly lower than those in peripheral blood of stable CAD patients. Low expression of CPNE3 gene was found to be unrelated to level of fasting blood glucose and serum blood lipid of patients, quantity of cardiac troponin and time of onset but was found to be correlated to the Gensini score for coronary artery. When the ex- pression of CPNE3 gene at the mRNA level in peripheral blood was used as the criterion for diagnosing AMI, its sensitivity, specificity, positive predictive value and negative predictive value were 69%, 64.8%, 68.6% and 65.2%, respectively.  Conclusions: Compared to stable CAD patients, AMI patients have a lower expression of CPNE3 gene in their peripheral blood. Patients who have low CPNE3 expression in peripheral blood are more likely to suffer from AMI than those with stable CAD. Low expression of CPNE3 gene serves as an potential independent risk factor of AMI.

Low expression of Notch1 may be associated with acute myocardial infarction

BackgroundThe transmembrane protein Notch1 is associated with cell growth, development, differentiation, proliferation, apoptosis, adhesion, and the epithelial mesenchymal transition. Proteomics, as a research method, uses a series of sequencing techniques to study the composition, expression levels, and modifications of proteins. Here, the association between Notch1 and acute myocardial infarction (AMI) was investigated using proteomics, to assess the possibility of using Notch1 as a biomarker for the disease.MethodsFifty-five eligible patients with AMI and 74 with chronic coronary syndrome (CCS) were enrolled, representing the experimental and control groups, respectively. The mRNA levels were assessed using RT-qPCR and proteins were measured using ELISA, and the results were compared and analyzed.ResultsNotch1 mRNA levels were 0.52 times higher in the peripheral blood mononuclear cells of the AMI group relative to the CCS group (p < 0.05) while Notch1 protein levels were 0.63 times higher in peripheral blood plasma in AMI patients (p < 0.05). Notch1 levels were not associated with older age, hypertension, smoking, high abdominal-blood glucose, high total cholesterol, and high LDL in AMI. Logistic regression indicated associations between AMI and reduced Notch1 expression, hypertension, smoking, and high fasting glucose.ConclusionsNotch1 expression was reduced in the peripheral blood of patients with AMI relative to those with CCS. The low expression of Notch1 was found to be an independent risk factor for AMI and may thus be an indicator of the disease

Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups

This study aimed to evaluate the role of off-pump coronary artery bypass (CAB) surgery on the decrease of postoperative inflammatory responses in patients. We systematically searched databases of PubMed and Embase to select the related studies. Interleukin (IL) 6, 8, and 10 were used as outcomes and pooled analysis was performed using R 3.12 software. Standardized mean differences (SMDs) and their 95% confidence intervals (95% CIs) were considered as effect estimates. A total of 27 studies, including 1340 participants, were recruited in this meta-analysis. The pooled analyses showed that postoperative concentration of IL-10 at 12 hours was significantly lower in off-pump CAB group compared to on-pump CAB group (SMD = −1.3640, 95% CI = −2.0086-−0.7193). However, no significant differences were found in pre and postoperative concentrations of IL-6 and 8 between off-pump and on-pump CAB groups. These results suggest that there is no advantage of off-pump CAB surgery in the reduction of inflammation compared to on-pump CAB surgery