1,782 research outputs found

    Development and current situation of organic agriculture in Brazil and the State of Sao Paulo.

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    A description of the organic production in Brazil as well as an in-depth analysis of the organic sector in the State of Sao Paulo

    Modeling in TRNSYS of a single effect evaporation system powered by a Rankine cycle

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    The paper presents an analysis of a Single Effect Evaporation (SEE) system as a pre-study to the feasibility of concentrated solar power plants (CSP) powering desalination units for cogeneration of water and electricity. An algorithm to model a SEE system in steady-state operation was made and is described in this work. This algorithm was implemented in TRNSYS environment, and a simple analysis was conducted of a SEE system powered by a Rankine cycle used in CSP plants

    Experimental validation of MED forward feed steady-state model

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    In this work the validation of a physical model to simulate the performance of an MED forward feed system is done by comparing results of the model with real data obtained. The data was obtained using the experimental MED plant at Plataforma Solar de Almeria (PSA) under steady-state operation near design conditions. The results indicate that the model can be used to make a first analysis on these type of systems.

    Effect of abutment angulation in the retention and durability of three overdenture attachment systems: An in vitro study

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    PURPOSE. This in vitro study investigated and compared the durability and retention of three types of attachments. MATERIALS AND METHODS. Three commercially available attachments were investigated: Clix (R), Dalbo-Plus (R) and Locator (R). In total, 72 samples of these attachments were placed in the acrylic resin forms and subjected to mechanical testing (5400 cycles of insertion and removal) over the respective ball or Locator abutments immersed in artificial saliva at pH 7 and 37 degrees C. The abutments were placed at angulations of 0 degrees, 10 degrees and 20 degrees. The retention force was recorded at the beginning and after 540, 1080, 2160, 3240, 4320 and 5400 insertion-removal cycles. RESULTS. The results revealed that there were significant differences in the average values of the insertion/removal force due to angulation (F ((2.48)) = 343619, P<.05) and the type of attachment (F ((7.48)) = 23.220, P<.05). CONCLUSION. Greater angulation of the abutments was found to influence the retention capacity of the attachments, and the fatigue test simulating 5 years of denture insertion and removal did not produce wear in the metal abutments.info:eu-repo/semantics/publishedVersio

    Autologous stem cell transplantation for the treatment of pediatric solid tumors in Brazil

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    Hosp Clin, Pediat Oncol Unit, Porto Alegre, RS, BrazilUniversidade Federal de S√£o Paulo, GRAACC, Pediat Oncol Inst, S√£o Paulo, BrazilHosp AC Camargo Fund Antonio Prudente, Dept Pediat, S√£o Paulo, BrazilSanta Casa de S√£o Paulo, Pediat Hematol & Bone Marrow Transplantat Unit, S√£o Paulo, BrazilUniversidade Federal de S√£o Paulo, GRAACC, Pediat Oncol Inst, S√£o Paulo, BrazilWeb of Scienc

    Pump and probe spectroscopy of A Cr+3-doped glass

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    Probe beam modulation in Cr+3-doped glasses induced by a high intensity pump laser is reported. A non-degenerate pump and probe geometry is used. Laser induced clearing and darkening effects and non-linear switching were observed. The effective relaxation time for this system was measured

    Methods and approaches for blind test predictions of out-of-plane behavior of masonry walls: a numerical comparative study

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    Earthquakes cause severe damage to masonry structures due to inertial forces acting in the normal direction to the plane of the walls. The out-of-plane behavior of masonry walls is complex and depends on several parameters, such as material and geometric properties of walls, connections between structural elements, the characteristics of the input motions, among others. Different analytical methods and advanced numerical modeling are usually used for evaluating the out-of-plane behavior of masonry structures. Furthermore, different types of structural analysis can be adopted for this complex behavior, such as limit analysis, pushover, or nonlinear dynamic analysis.Aiming to evaluate the capabilities of different approaches to similar problems, blind predictions were made using different approaches. For this purpose, two idealized structures were tested on a shaking table and several experts on masonry structures were invited to present blind predictions on the response of the structures, aiming at evaluating the available tools for the out-of-plane assessment of masonry structures. This article presents the results of the blind test predictions and the comparison with the experimental results, namely in terms of formed collapsed mechanisms and control outputs (PGA or maximum displacements), taking into account the selected tools to perform the analysis.info:eu-repo/semantics/publishedVersio

    Determinants of reef fish assemblages in tropical Oceanic islands

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    Diversity patterns are determined by biogeographic, energetic, and anthropogenic factors, yet few studies have combined them into a large‚Äźscale framework in order to decouple and compare their relative effects on fish faunas. Using an empirical dataset derived from 1527 underwater visual censuses (UVC) at 18 oceanic islands (five different marine provinces), we determined the relative influence of such factors on reef fish species richness, functional dispersion, density and biomass estimated from each UVC unit. Species richness presented low variation but was high at large island sites. High functional dispersion, density, and biomass were found at islands with large local species pool and distance from nearest reef. Primary productivity positively affected fish richness, density and biomass confirming that more productive areas support larger populations, and higher biomass and richness on oceanic islands. Islands densely populated by humans had lower fish species richness and biomass reflecting anthropogenic effects. Species richness, functional dispersion, and biomass were positively related to distance from the mainland. Overall, species richness and fish density were mainly influenced by biogeographical and energetic factors, whereas functional dispersion and biomass were strongly influenced by anthropogenic factors. Our results extend previous hypotheses for different assemblage metrics estimated from empirical data and confirm the negative impact of humans on fish assemblages, highlighting the need for conservation of oceanic islands.UCR::Vicerrector√≠a de Investigaci√≥n::Unidades de Investigaci√≥n::Ciencias B√°sicas::Centro de Investigaci√≥n en Ciencias del Mar y Limnolog√≠a (CIMAR

    Characterization of the genetic diversity of Mycobacterium tuberculosis in S√£o Paulo city, Brazil

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    <p>Abstract</p> <p>Background</p> <p>Tuberculosis is a major health problem in S√£o Paulo, Brazil, which is the most populous and one of the most cosmopolitan cities in South America. To characterize the genetic diversity of <it>Mycobacterium tuberculosis </it>in the population of this city, the genotyping techniques of spoligotyping and MIRU were applied to 93 isolates collected in two consecutive years from 93 different tuberculosis patients residing in S√£o Paulo city and attending the Clemente Ferreira Institute (the reference clinic for the treatment of tuberculosis).</p> <p>Findings</p> <p>Spoligotyping generated 53 different spoligotype patterns. Fifty-one isolates (54.8%) were grouped into 13 spoligotyping clusters. Seventy- two strains (77.4%) showed spoligotypes described in the international databases (SpolDB4, SITVIT), and 21 (22.6%) showed unidentified patterns. The most frequent spoligotype families were Latin American Mediterranean (LAM) (26 isolates), followed by the T family (24 isolates) and Haarlem (H) (11 isolates), which together accounted for 65.4% of all the isolates. These three families represent the major genotypes found in Africa, Central America, South America and Europe. Six Spoligo-International-types (designated SITs by the database) comprised 51.8% (37/72) of all the identified spoligotypes (SIT53, SIT50, SIT42, SIT60, SIT17 and SIT1). Other SITs found in this study indicated the great genetic diversity of <it>M. tuberculosis</it>, reflecting the remarkable ethnic diversity of S√£o Paulo city inhabitants. The MIRU technique was more discriminatory and did not identify any genetic clusters with 100% similarity among the 93 isolates. The allelic analysis showed that MIRU loci 26, 40, 23 and 10 were the most discriminatory. When MIRU and spoligotyping techniques were combined, all isolates grouped in the 13 spoligotyping clusters were separated.</p> <p>Conclusions</p> <p>Our data indicated the genomic stability of over 50% of spoligotypes identified in S√£o Paulo and the great genetic diversity of <it>M. tuberculosis </it>isolates in the remaining SITs, reflecting the large ethnic mix of the S√£o Paulo city inhabitants. The results also indicated that in this city, <it>M. tuberculosis </it>isolates acquired drug resistance independently of genotype and that resistance was more dependent on the selective pressure of treatment failure and the environmental circumstances of patients.</p

    MASTL promotes cell contractility and motility through kinase-independent signaling

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    Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accelerating kinase with emerging roles in cancer progression. However, possible cell cycle-independent mechanisms behind its oncogenicity remain ambiguous. Here, we identify MASTL as an activator of cell contractility and MRTF-A/SRF (myocardin-related transcription factor A/serum response factor) signaling. Depletion of MASTL increased cell spreading while reducing contractile actin stress fibers in normal and breast cancer cells and strongly impairing breast cancer cell motility and invasion. Transcriptome and proteome profiling revealed MASTL-regulated genes implicated in cell movement and actomyosin contraction, including Rho guanine nucleotide exchange factor 2 (GEF-H1, ARHGEF2) and MRTF-A target genes tropomyosin 4.2 (TPM4), vinculin (VCL), and nonmuscle myosin IIB (NM-2B, MYH10). Mechanistically, MASTL associated with MRTF-A and increased its nuclear retention and transcriptional activity. Importantly, MASTL kinase activity was not required for regulation of cell spreading or MRTF-A/SRF transcriptional activity. Taken together, we present a previously unknown kinase-independent role for MASTL as a regulator of cell adhesion, contractility, and MRTF-A/SRF activity. [Abstract copyright: © 2020 Taskinen et al.
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