Discovering Electroweak Interacting Dark Matter at Muon Colliders using Soft Tracks

Minimal Dark Matter models feature one neutral particle that serves as a thermal relic dark matter candidate, as well as quasi-degenerate charged states with TeV masses. When the charged states are produced at colliders, they can decay into dark matter and a low-momentum (soft) charged particle, which is challenging to reconstruct at hadron colliders. We demonstrate that a 3 TeV Muon Collider is capable of detecting these soft tracks, enabling the discovery of thermal Higgsinos and similar dark matter candidates which constitute highly motivated scenarios for future collider searches.Comment: 4 pages, 1 Table, 5 Figure

Hunting wino and higgsino dark matter at the muon collider with disappearing tracks

We study the capabilities of a muon collider experiment to detect disappearing tracks originating when a heavy and electrically charged long-lived particle decays via $X^+ \to Y^+ Z^0$, where $X^+$ and $Z^0$ are two almost mass degenerate new states and $Y^+$ is a charged Standard Model particle. The backgrounds induced by the in-flight decays of the muon beams (BIB) can create detector hit combinations that mimic long-lived particle signatures, making the search a daunting task. We design a simple strategy to tame the BIB, based on a detector-hit-level selection exploiting timing information and hit-to-hit correlations, followed by simple requirements on the quality of reconstructed tracks. Our strategy allows us to reduce the number of tracks from BIB to an average of 0.08 per event, hence being able to design a cut-and-count analysis that shows that it is possible to cover weak doublets and triplets with masses close to $\sqrt{s}/2$ in the 0.1-10 ns range. In particular, this implies that a 10 TeV muon collider is able to probe thermal MSSM higgsinos and thermal MSSM winos, thus rivaling the FCC-hh in that respect, and further enlarging the physics program of the muon collider into the territory of WIMP dark matter and long-lived signatures. We also provide parton-to-reconstructed level efficiency maps, allowing an estimation of the coverage of disappearing tracks at muon colliders for arbitrary models.Comment: 32 pages, 17 figures, 3 table

To What Extent Are Existing Volume Mapping Algorithms Practically Useful?

Mappings between geometric domains play a crucial role in many algorithms in geometry processing and are heavily used in various applications. Despite the significant progress made in recent years, the challenge of reliably mapping two volumes still needs to be solved to an extent that is satisfactory for practical applications. This paper offers a review of provably robust volume mapping algorithms, evaluating their performances in terms of time, memory and ability to generate a correct result both with exact and inexact numerical models. We have chosen and evaluated the two most advanced methods currently available, using a state-of-the-art benchmark designed specifically for this type of analysis. We are sharing both the statistical results and specific volume mappings with the community, which can be utilized by future algorithms for direct comparative analysis. We also provide utilities for reading, writing, and validating volume maps encoded with exact rational coordinates, which is the natural form of output for robust algorithms in this class. All in all, this benchmark offers a neat overview of where do we stand in terms of ability to reliably solve the volume mapping problem, also providing practical data and tools that enable the community to compare future algorithmic developments without the need to re-run existing methods

Digital vs formal teaching of vaginal breech delivery: Which is the residents’ choice?

Objective(s): A critical area of obstetrics that demands proficient training is the management of breech deliveries. There was a notable decline in the number of vaginal breech deliveries in the following years, establishing CS as the preferred method of delivery for such cases. Cohort studies using targeted screening and skilled practitioners demonstrated little differences between the two delivery. Skills acquisition at the patient’s bedside is very difficult to obtain, particularly in the youngest trainees. Simulation teaching has largely become a part of the training curricula for many obstetrics and gynecology residency programs. Study design: This was a prospective, randomized, controlled, single-center study. Residents were randomly assigned in two groups with similar characteristics. Group A attended a formal lecture. Group B received the study material and recording of the lecture as digital home learning. Lecture and simulation focused on vaginal breech delivery. After one month both groups underwent a simulation test addressed to assist a vaginal breech birth. Four supervisors evaluated all videos. Time needed for birth, and evaluation scales as Objective Structured Clinical Examination were recorded. A questionnaire was completed online using Google Forms with 6 questions. The primary outcome was to compare the evaluation for each item and globally within groups. A secondary outcome was the evaluation of questionnaire results within the two groups. Results: Thirty-two participants were recruited and randomized. None of the participants withdrew from the study. For the primary outcome, all examined variables (Time, Rumping, Legs, Body, Arms, Head, Total Point) did not present differences in supervisors’ evaluations. For the secondary outcome, Group B showed higher values in two questions. Conclusion(s): The major finding of our study is that digital learning and formal lecture presented similar results on resident knowledge. Teaching programs involving mannequin simulation − both high and low fidelity − are reproducible and efficient for skill retain in obstetric emergencies, particularly in low incidence emergencies. The main limitation of our study was the small sample size. In addition, it is possible that a scenario without deviation or a lecture more focused on possible deviation from normal could modify residents’ results facing breech delivery

Incidence of non-Hodgkin’s lymphoma among adults in Sardinia, Italy

The causes of the peculiar time trend in the incidence of non-Hodgkin’s lymphoma (NHL) in most parts of the world and of its geographic distribution are still unknown. We used the data base of 1974–2003 incident cases of hematological malignancies to explore the time trend of NHL incidence in the region of Sardinia, Italy, and we used Bayesian methods to plot the probability of NHL incidence by residential unit on the regional map. In 1974–2003, 4109 NHL cases were diagnosed among resident adults in Sardinia, with an incidence rate of 13.38 x 10(−5) (95% CI 12.97–13.80). NHL incidence showed an upward trend along the study period with an average annual percent change (APC) of 4.94 (95% CI -5.39–16.4), which did not vary by gender or by age-group. Cancer registry data, covering part of the region starting from 1993, suggest that the increasing trend did not persist in the subsequent years. Areas with the highest probability of an excess incidence tended to cluster in the north-eastern part of the region and in two major urban centers, with the low incidence areas located in the south, confirming previous observations. Prevalence of viral infections, environmental and occupational exposures, or socio-economic deprivation would not explain the peculiar geographic distribution we observed. These findings provide convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants of NHL in the risk areas

Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy

A few reports have described increasing trends and spatial distribution of multiple myeloma (MM). We used a validated database including the 1606 cases of MM diagnosed in Sardinia in 1974–2003 to explore its time trend, and we applied Bayesian methods to plot MM probability by administrative unit on the regional map. Over the 30 years of observation, the MM standardized incidence rate (standard world population, all ages) was 2.17 × 10(–5) (95% CI 2.01–2.34), 2.29 (95% CI 2.06–2.52) among men, and 2.06 (95% CI 1.83–2.28) among women. MM incidence increased by 3.3%/year in 1974–2003, in both males and females, particularly among the elderly and in the high incidence areas. Areas at risk tended to cluster in the north-eastern part of the region. A higher proportion of elderly in the resident population, but not socioeconomic factors, nor livestock farming, was associated with higher incidence rates. The steep upward time trend and the spatial clustering of MM suggest interactions between genetic and environmental determinants that might be more efficiently investigated in the areas at risk

Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives

Squamous cell carcinoma (SCC) is one of the most frequent tumors of skin and muco-cutaneous junctions in the horse. Equine papillomavirus type 2 (EcPV2) has been detected in equine SCC of the oral tract and genitals, and recently also in the larynx. As human squamous cell carcinoma of the larynx (SCCL), it is strongly etiologically associated with high-risk papillomavirus (h-HPV) infection. This study focuses on tumor cells behavior in a naturally occurring tumor that can undergo the so-called epithelial to mesenchymal transition (EMT). A SCCL in a horse was investigated by immunohistochemistry using antibodies against E-cadherin, pan-cytokeratin AE3/AE1, β-catenin, N-cadherin, vimentin, ZEB-1, TWIST, and HIF-1α. EcPV2 DNA detection and expression of oncogenes in SCC were investigated. A cadherin switch and an intermediate filaments rearrangement within primary site tumor cells together with the expression of the EMT-related transcription factors TWIST-1, ZEB-1, and HIF-1α were observed. DNA obtained from the tumor showed EcPV2 positivity, with E2 gene disruption and E6 gene dysregulation. The results suggest that equine SCCL might be a valuable model for studying EMT and the potential interactions between EcPV2 oncoproteins and the EMT process in SCCL